4.6 Article

Exploration of the Role of the C-Terminal Domain of Human DNA Topoisomerase IIα in Catalytic Activity

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Summary: DNA topoisomerases are essential for cellular survival, playing numerous roles in DNA metabolism. Structural approaches and single-molecule techniques have provided new insights into their interaction and mechanism, while the importance of interactions with other proteins has been highlighted. Novel topoisomerases like topo VIII and Mini-A are expanding our understanding of DNA processes and the vital functions they perform.

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