期刊
BRAIN SCIENCES
卷 12, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/brainsci12010096
关键词
intraoperative hypothermia; postoperative cognitive dysfunction; hippocampus; synaptic plasticity; synaptic plasticity-related protein
资金
- Post-Doctoral Science Foundation of China [2019M660550]
- National Natural Science Youth Foundation of China [81900433]
- National Natural Science Foundation of China
This study aimed to evaluate the effects of intraoperative hypothermia on postoperative cognitive function in rats and investigate the possible mechanisms. The results suggest a correlation between intraoperative hypothermia and POCD in rats, which may result in impairments in spatial working memory, spatial learning, and memory.
Intraoperative hypothermia is a common complication during operations and is associated with several adverse events. Postoperative cognitive dysfunction (POCD) and its adverse consequences have drawn increasing attention in recent years. There are currently no relevant studies investigating the correlation between intraoperative hypothermia and POCD. The aim of this study was to assess the effects of intraoperative hypothermia on postoperative cognitive function in rats undergoing exploratory laparotomies and to investigate the possible related mechanisms. We used the Y-maze and Morris Water Maze (MWM) tests to assess the rats' postoperative spatial working memory, spatial learning, and memory. The morphological changes in hippocampal neurons were examined by haematoxylin-eosin (HE) staining and hippocampal synaptic plasticity-related protein expression. Activity-regulated cytoskeletal-associated protein (Arc), cyclic adenosine monophosphate-response element-binding protein (CREB), S133-phosphorylated CREB (p-CREB [S133]), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor 1 (AMPAR1), and S831-phosphorylated AMPAR1 (p-AMPAR1 [S831]) were evaluated by Western blotting. Our results suggest a correlation between intraoperative hypothermia and POCD in rats and that intraoperative hypothermia may lead to POCD regarding impairments in spatial working memory, spatial learning, and memory. POCD induced by intraoperative hypothermia might be due to hippocampal neurons damage and decreased expression of synaptic plasticity-related proteins Arc, p-CREB (S133), and p-AMPAR1 (S831).
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