Synthesis of silver nanoparticle (Ag NPs) using phytochemical rich medicinal plant Lonicera japonica for improve the cytotoxicity effect in cancer cells

Initially, the excellent anti-oxidant property of the Ag NPs was synthesized from Chinese medicinal plant of Lonicera japonica, and their spectroscopic evidences were confirmed by UV-spectrometer. The mor-phology, size and shape of the synthesized Ag NPs were effectively identified by scanning electron micro-scope and transmission electron microscope. Both the spectroscopic results were more evident, which UV-spectrometer peak was exhibited at 456 nm, scanning electron microscope and transmission electron microscope results were also clearly shown ball like spherical shape. The potential anti-cancer effect of the Ag NPs was revealed, the selected Chinese plant Lonicera japonica was influenced the A549 lung can-cer cells through excessive ROS production. The IC50 concentration of 75 mu g/mL was shown decreased via-bility in Ag NPs treated A549 lung cancer cells of MTT assay. Consecutively, the MTT assay result was proved by irregular shape and damaged morphology in A549 lung cancer cells by images of phase con-trast microscope. Finally, the result was also clearly stated that the synthesized Ag NPs was very effective against A549 human lung cancer cells and it use for future drug discovery for inhibiting the lung cancer. (c) 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

This study synthesized silver nanoparticles with excellent antioxidant properties from the Chinese medicinal plant Lonicera japonica, and their morphology and spectroscopic evidence were determined. The results showed that the silver nanoparticles exhibited strong anti-cancer effects against lung cancer cells.