期刊
ANTIBIOTICS-BASEL
卷 10, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics10111275
关键词
Combretum erythrophyllum; platinum nanoparticles; green synthesis; antibacterial; Klebsiella oxytoca; Klebsiella aerogenes
资金
- National Research Foundation (N.R.F) under the Competitive Programme for Rated Researchers (CPRR) [129290]
- University of Johannesburg research committee (URC)
- Faculty of Science research committee (FRC)
Nanobiotechnology shows promise in developing green antibiotics to combat the rising trend of antibiotic resistance. Plant-mediated synthesis of platinum nanoparticles has been proven to be effective in providing nano-antibiotics with strong antibacterial activities.
Nanobiotechnology is a promising field in the development of safe antibiotics to combat the increasing trend of antibiotic resistance. Nature is a vast reservoir for green materials used in the synthesis of non-toxic and environmentally friendly nano-antibiotics. We present for the first time a facile, green, cost-effective, plant-mediated synthesis of platinum nanoparticles (PtNPs) using the extract of Combretum erythrophyllum (CE) plant leaves. The extract of CE served as both a bio-reductant and a stabilizing agent. The as-synthesized PtNPs were characterized using ultraviolet-visible (UV-Vis) absorption spectroscopy, high-resolution transmission electron microscopy (HR-TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and dynamic light scattering (DLS) techniques. The HR-TEM image confirmed that the PtNPs are ultrasmall, spherical, and well dispersed with an average particle diameter of 1.04 +/- 0.26 nm. The PtNPs showed strong antibacterial activities against pathogenic Gram-positive Staphylococcus epidermidis (ATCC 14990) at a minimum inhibitory concentration (MIC) of 3.125 mu g/mL and Gram-negative Klebsiella oxytoca (ATCC 8724) and Klebsiella aerogenes (ATCC 27853) at an MIC value of 1.56 mu g/mL. The CE-stabilized PtNPs was mostly effective in Klebsiella species that are causative organisms in nosocomial infections.
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