Novel Plant-Based Metabolites as Disinfectants against Acanthamoeba castellanii

Article Parasitology

Phytochemical, anti-Acanthamoeba, and anti-adhesion properties of Garcinia mangostana flower as preventive contact lens solution

Suthinee Sangkanu et al.

Summary: Compounds isolated from Garcinia mangostana flower show anti-Acanthamoeba and anti-adhesion activity, with alpha-mangostin being a potential candidate for treating Acanthamoeba infections or as a lens care solution.

ACTA TROPICA (2022)

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Article Chemistry, Applied

New bioactive monoterpene indole alkaloid from Rinorea yaundensis Engl.

Bushra Khatoon et al.

Summary: A new monoterpene indole alkaloid (1) and 10 known compounds (2-11) were isolated from the aerial part of Rinorea yaundensis for the first time. The structures of these compounds were determined using HRMS and NMR spectroscopic analyses. Yaundentine hydrochloride (1) exhibited pronounced antioxidant, urease, lipoxygenase inhibitory activities, and antimicrobial activity against some Gram positive and negative bacteria.

NATURAL PRODUCT RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Nanovesicles containing curcumin hold promise in the development of new formulations of anti-Acanthamoebic agents

Balsam Qubais Saeed et al.

Summary: The study revealed that curcumin-loaded nanovesicles showed enhanced anti-Acanthamoebic effects compared to curcumin alone. Both curcumin and curcumin-loaded nanovesicles exhibited minimal cytotoxic effects against human cells at all tested concentrations. These findings suggest that curcumin-loaded nanovesicles have the potential to be a promising new formulation for anti-Acanthamoebic agents.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2022)

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Article Public, Environmental & Occupational Health

Opportunistic free-living amoebal pathogens

Mohammad Ridwane Mungroo et al.

Summary: Pathogenic free-living amoebae can cause severe central nervous system diseases, with hosts with impaired immunity being at higher risk, but they can also affect immunocompetent individuals. Recently, these deadly amoebae were detected in water supplies in the USA, raising concerns, especially with global warming potentially exacerbating the issue.

PATHOGENS AND GLOBAL HEALTH (2022)

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Article Medicine, General & Internal

Granulomatous amoebic encephalitis caused by Acanthamoeba in a patient with AIDS: a challenging diagnosis

Hsien Lee Lau et al.

Summary: This case highlights the importance of considering granulomatous amoebic encephalitis in the differential diagnosis of brain masses. Early molecular testing of tissue specimens by the CDC is advocated for achieving an accurate diagnosis, and a multidisciplinary approach is recommended for managing this condition.

ACTA CLINICA BELGICA (2021)

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Article Biochemical Research Methods

Hydroxypropyl methyl cellulose-Satureja hortensis L. ethanol extract mixtures as antimicrobial coating for sutures, identification of phenolic acids by using LC-MS-MS and TLC techniques

Mustafa Akin et al.

Summary: The study identified thymol, vanillic acid, and caffeic acid in the ethanol extract of Satureja hortensis. The combination of plant extract with HPMC showed inhibitory activity against Gram-positive bacteria. Coated sutures exhibited antimicrobial activity against both S. aureus and Bacillus cereus.

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES (2021)

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Review Biochemistry & Molecular Biology

Chemical Strategies towards the Synthesis of Betulinic Acid and Its More Potent Antiprotozoal Analogues

Andre Barreto Cunha et al.

Summary: Betulinic acid (BA) is a pentacyclic triterpene acid found in various plant species. It exhibits diverse pharmacological properties, including antiprotozoal, antimalarial, antileishmanial, and antitrypanosomal activities. By synthesizing analogues, it is possible to enhance its antiprotozoal activity, making it a promising starting material for novel antiprotozoal agents.

MOLECULES (2021)

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Review Biotechnology & Applied Microbiology

Natural products in drug discovery: advances and opportunities

Atanas G. Atanasov et al.

Summary: Natural products and their analogues have historically played a significant role in pharmacotherapy, however, they also present challenges. Recent technological and scientific developments are addressing these challenges and revitalizing interest in natural products as drug leads, particularly for combating antimicrobial resistance.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Medicine, General & Internal

Challenges in Acanthamoeba Keratitis: A Review

Giuseppe Varacalli et al.

Summary: The diagnosis and management of Acanthamoeba keratitis (AK) pose challenges, with delayed treatment leading to poorer visual outcomes. Standardized antiamoebic therapies are crucial in improving visual outcomes, shortening treatment duration, and reducing the need for surgical intervention, highlighting the importance of timely diagnosis and treatment in AK management.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Infectious Diseases

Acanthamoeba Keratitis: an update on amebicidal and cysticidal drug screening methodologies and potential treatment with azole drugs

Brian Shing et al.

Summary: Treatment of Acanthamoeba keratitis remains challenging and requires exploration of new anti-Acanthamoeba methods. Current treatment approaches are diverse, but none is universally effective. The efficacy of azole antifungal agents against Acanthamoeba keratitis needs further investigation.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2021)

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Article Biotechnology & Applied Microbiology

Development of anti-acanthamoebic approaches

Mohammad Ridwane Mungroo et al.

Summary: Acanthamoeba keratitis is a serious eye infection that threatens vision, and current treatments are burdensome with contact lens disinfectants unable to effectively eradicate the causative organism. Certain compounds show anti-amoebic effects without significant toxicity to human cells, suggesting potential for future applications after further evaluation with nanoparticles.

INTERNATIONAL MICROBIOLOGY (2021)

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Article Microbiology

Molecular Identification of Pathogenic Free-Living Amoeba from Household Biofilm Samples in Iran: A Risk Factor for Acanthamoeba Keratitis

Maryam Norouzi et al.

Summary: The study found that some household biofilm samples in Iran contain FLA, posing potential risks to people using soft contact lenses and patients with traumatic cataract. Filtration should be performed in shower heads and monitoring is needed for individuals at higher risk of Acanthamoeba keratitis.

MICROORGANISMS (2021)

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Article Parasitology

High oxygen concentrations inhibit Acanthamoeba spp.

Ines Sifaoui et al.

Summary: Increasing oxygen concentrations can significantly reduce the growth of Acanthamoeba and increase ROS production, leading to growth inhibition due to oxidative stress. Further studies are needed to determine the level of oxygen saturation, exposure time, and number of sessions required to eliminate the parasite.

PARASITOLOGY RESEARCH (2021)

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Article Parasitology

In vitro amoebicidal effects of arabinogalactan-based ophthalmic solution

M. Reyes-Batlle et al.

Summary: Acanthamoeba keratitis (AK) is a corneal infection with symptoms like eye redness and pain, and there is currently no established treatment. Research has shown that Matrix Ocular (R) has high anti-Acanthamoeba activity without toxic effects on the eye, suggesting Arabinogalactan derivatives as a new source of anti-AK compounds.

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2021)

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Review Ophthalmology

Acanthamoeba keratitis: a review of biology, pathophysiology and epidemiology

Ana Gomes de Lacerda et al.

Summary: Acanthamoeba keratitis is a widespread infection caused by a unicellular protozoan that mainly affects contact lens wearers and is linked to corneal trauma as well. It is essential to deepen the understanding of risk factors, focus on prevention strategies, and enhance the efficacy of disinfection systems to minimize the risk of infection. Additionally, there is a need for the development of effective diagnostic methods and treatments for this type of corneal infection in the near future.

OPHTHALMIC AND PHYSIOLOGICAL OPTICS (2021)

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Review Biotechnology & Applied Microbiology

Betulin and its derivatives as novel compounds with different pharmacological effects

Shayan Amiri et al.

BIOTECHNOLOGY ADVANCES (2020)

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Article Microbiology

The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii

Brian Shing et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

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Review Parasitology

Is Naegleria fowleri an Emerging Parasite?

Sutherland K. Maciver et al.

TRENDS IN PARASITOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Antiamoebic activity of plant-based natural products and their conjugated silver nanoparticles against Acanthamoeba castellanii (ATCC 50492)

Areeba Anwar et al.

AMB EXPRESS (2020)

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Article Infectious Diseases

Antibacterial Activities of Selected Pure Compounds Isolated from Gut Bacteria of Animals Living in Polluted Environments

Noor Akbar et al.

ANTIBIOTICS-BASEL (2020)

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Review Microbiology

Antimicrobial Activity of Polyphenols and Alkaloids in Middle Eastern Plants

Leen Othman et al.

FRONTIERS IN MICROBIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Enhancing effect of cystamine in its amides with betulinic acid as antimicrobial and antitumor agent in vitro

Uladzimir Bildziukevich et al.

STEROIDS (2019)

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Article Public, Environmental & Occupational Health

In Vitro Antimicrobial Activity of Some Medicinal Plants against Human Pathogenic Bacteria

Sarita Manandhar et al.

JOURNAL OF TROPICAL MEDICINE (2019)

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Article Parasitology

Tannic acid-modified silver nanoparticles as a novel therapeutic agent against Acanthamoeba

Marcin Padzik et al.

PARASITOLOGY RESEARCH (2018)

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Article Parasitology

Status of the effectiveness of contact lens disinfectants in Malaysia against keratitis-causing pathogens

Farhat Abjani et al.

EXPERIMENTAL PARASITOLOGY (2017)

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Article Biochemistry & Molecular Biology

Brain-Eating Amoebae: Silver Nanoparticle Conjugation Enhanced Efficacy of Anti-Amoebic Drugs against Naegleria fowleri

Kavitha Rajendran et al.

ACS CHEMICAL NEUROSCIENCE (2017)

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Review Pharmacology & Pharmacy

Antimicrobial activity of Nigerian medicinal plants

Madubuike Umunna Anyanwu et al.

JOURNAL OF INTERCULTURAL ETHNOPHARMACOLOGY (2017)

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Article Microbiology

Amoebicidal Activity of Caffeine and Maslinic Acid by the Induction of Programmed Cell Death in Acanthamoeba

Carmen M. Martin-Navarro et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)

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Review Ophthalmology

Strategies for the prevention of contact lens-related Acanthamoeba keratitis: a review

Nicole Carnt et al.

OPHTHALMIC AND PHYSIOLOGICAL OPTICS (2016)

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Review Ophthalmology

Update on Acanthamoeba Keratitis: Diagnosis, Treatment, and Outcomes

Nicholas J. R. Maycock et al.

CORNEA (2016)

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Article Parasitology

Inefficacy of marketed contact lens disinfection solutions against keratitis-causing Acanthamoeba castellanii belonging to the T4 genotype

Sahreena Lakhundi et al.

EXPERIMENTAL PARASITOLOGY (2014)

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Article Immunology

Potent anti-inflammatory activity of betulinic acid treatment in a model of lethal endotoxemia

Jose Fernando Oliveira Costa et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2014)

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Article Parasitology

The effect of different environmental conditions on the encystation of Acanthamoeba castellanii belonging to the T4 genotype

Yousuf Aqeel et al.

EXPERIMENTAL PARASITOLOGY (2013)

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Review Parasitology

Acanthamoeba keratitis: an emerging disease gathering importance worldwide?

Jacob Lorenzo-Morales et al.

TRENDS IN PARASITOLOGY (2013)

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Article Parasitology

In vitro amoebicidal activity of Origanum syriacum and Origanum laevigatum on Acanthamoeba castellanii cysts and trophozoites

Serpil Degerli et al.

EXPERIMENTAL PARASITOLOGY (2012)

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Review Biochemistry & Molecular Biology

Medicinal Plants: A Source of Anti-Parasitic Secondary Metabolites

Michael Wink

MOLECULES (2012)

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Review Parasitology

Biology and pathogenesis of Acanthamoeba

Ruqaiyyah Siddiqui et al.

PARASITES & VECTORS (2012)

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Article Parasitology

Chemical composition and amoebicidal activity of Croton pallidulus, Croton ericoides, and Croton isabelli(Euphorbiaceae) essential oils

Sita Luvangadio Lukoki Vunda et al.

PARASITOLOGY RESEARCH (2012)

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Article Critical Care Medicine

Acute Granulomatous Acanthamoeba Encephalitis in an Immunocompetent Patient

Peter Lackner et al.

NEUROCRITICAL CARE (2010)

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Article Ophthalmology

In vitro evaluation of the amoebicidal activity of garlic (Allium sativum) extract on Acanthamoeba castellanii and its cytotoxic potential on corneal cells

Zubeyde Akin Polat et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2008)

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Review Pharmacology & Pharmacy

Drug discovery from natural sources

Young-Won Chin et al.

AAPS JOURNAL (2006)

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Review Biochemistry & Molecular Biology

Betulinic acid and its derivatives: A review on their biological properties

P Yogeeswari et al.

CURRENT MEDICINAL CHEMISTRY (2005)

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Article Biotechnology & Applied Microbiology

Resistance, biguanide sorption and biguanide-induced pentose leakage during encystment of Acanthamoeba castellanii

NA Turner et al.

JOURNAL OF APPLIED MICROBIOLOGY (2004)

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Review Microbiology

Acanthamoeba spp. as agents of disease in humans

F Marciano-Cabral et al.

CLINICAL MICROBIOLOGY REVIEWS (2003)

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Review Biochemistry & Molecular Biology

Polyphenolics of Salvia - a review

YR Lu et al.

PHYTOCHEMISTRY (2002)

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Article Chemistry, Medicinal

Constituents from Salvia triloba

NH El-Sayed et al.

FITOTERAPIA (2001)

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Novel Plant-Based Metabolites as Disinfectants against Acanthamoeba castellanii

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