Looking Back to Amycolatopsis: History of the Antibiotic Discovery and Future Prospects

The emergence of antibiotic-resistant pathogenic bacteria in recent decades leads us to an urgent need for the development of new antibacterial agents. The species of the genus Amycolatopsis are known as producers of secondary metabolites that are used in medicine and agriculture. The complete genome sequences of the Amycolatopsis demonstrate a wide variety of biosynthetic gene clusters, which highlights the potential ability of actinomycetes of this genus to produce new antibiotics. In this review, we summarize information about antibiotics produced by Amycolatopsis species. This knowledge demonstrates the prospects for further study of this genus as an enormous source of antibiotics.

Automated summary

The genus Amycolatopsis has been identified as a potential producer of new antibiotics, with its wide variety of biosynthetic gene clusters from complete genome sequences showcasing its ability to be a source of novel antibiotics. This knowledge highlights the prospects for further research on this genus as a significant source of antibiotics.