Possible COVID-19-Associated Pulmonary Aspergillosis Due to Aspergillus niger in Greece

Article Immunology

Tocilizumab for Treatment of Mechanically Ventilated Patients With COVID-19

Emily C. Somers et al.

Summary: In mechanically ventilated COVID-19 patients, the use of IL-6 blockade with tocilizumab was associated with lower mortality despite higher occurrence of superinfections.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Immunology

Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study

Michele Bartoletti et al.

Summary: The study showed a high incidence of CAPA among critically ill COVID-19 patients, and its occurrence seems to alter the natural course of the disease.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Dermatology

Invasive pulmonary aspergillosis in the COVID-19 era: An expected new entity

Marina Machado et al.

Summary: COVID-19-associated pulmonary aspergillosis is a serious and potentially life-threatening complication in severe COVID-19 patients, especially those receiving corticosteroids. Mortality rate in reviewed cases is high at 56.3%.

MYCOSES (2021)

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Review Anesthesiology

Mortality in patients admitted to intensive care with COVID-19: an updated systematic review and meta-analysis of observational studies

R. A. Armstrong et al.

Summary: The COVID-19 pandemic continues to impact critically ill patients globally, with ICU mortality rates varying across regions. While there has been a decrease in ICU mortality since May 2020, the lack of standardized reporting and patient-level data hinders a definitive evaluation of outcomes. More efforts towards standardization in reporting are needed to improve comparisons across different regions and studies.

ANAESTHESIA (2021)

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Review Medicine, General & Internal

Aspergillus Infections

George R. Thompson et al.

Summary: Aspergillosis is an opportunistic fungal infection that poses a particular risk for patients with neutrophil defects and causes diverse clinical syndromes. This review discusses current understanding and advances in diagnosis and treatment of aspergillosis.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Critical Care Medicine

New clinical algorithm including fungal biomarkers to better diagnose probable invasive pulmonary aspergillosis in ICU

Joffrey Hamam et al.

Summary: A new algorithm (BM-AspICU) including fungal biomarkers has been developed for the diagnosis of probable invasive pulmonary aspergillosis in ICU patients. This algorithm showed promising results and may be effective in identifying IPA cases in ICU population. Prospective studies are needed to further validate the routine application of this algorithm.

ANNALS OF INTENSIVE CARE (2021)

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Article Microbiology

Aspergillus Test Profiles and Mortality in Critically Ill COVID-19 Patients

Mehmet Ergun et al.

Summary: Literature on COVID-19-associated pulmonary aspergillosis has conflicting observations, with some CAPA patients surviving without antifungal therapy and discrepancies between CAPA diagnosis and autopsy findings. A case-control study was conducted comparing Aspergillus test profiles in CAPA patients and controls. The study showed that positive serum GM and BDG were associated with increased mortality in CAPA patients, highlighting the need for biomarkers to differentiate between respiratory tract colonization and tissue-invasive CAPA disease.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Infectious Diseases

Epidemiology and Incidence of COVID-19-Associated Pulmonary Aspergillosis (CAPA) in a Greek Tertiary Care Academic Reference Hospital

Elisabeth Paramythiotou et al.

Summary: In this study, the incidence of COVID-19 associated pulmonary aspergillosis (CAPA) in ICU patients was 3.3%, with a mortality rate of 67%. The majority of cases were co-infected with multidrug-resistant gram-negative pathogens, contributing to the high mortality rate.

INFECTIOUS DISEASES AND THERAPY (2021)

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Article Immunology

COVID-19-Associated Pulmonary Aspergillosis, March-August 2020

Jon Salmanton-Garcia et al.

Summary: This study found that most patients with coronavirus disease-associated pulmonary aspergillosis (CAPA) are diagnosed shortly after admission, with the majority being treated in the ICU. Azole-resistant strains of Aspergillus fumigatus were common in patients, and voriconazole was the main treatment choice. The overall mortality rate was approximately 52.2%, with about one third of deaths attributed to CAPA.

EMERGING INFECTIOUS DISEASES (2021)

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Article Immunology