4.6 Article

Efficacy of Thai Plant Extracts for Antibacterial and Anti-Biofilm Activities against Pathogenic Bacteria

期刊

ANTIBIOTICS-BASEL
卷 10, 期 12, 页码 -

出版社

MDPI
DOI: 10.3390/antibiotics10121470

关键词

antibacterial; anti-biofilm; Piper betle; Staphylococcus aureus; Escherichia coli; Thai plant extracts

资金

  1. National Science, Research and Innovation Fund (NSRF) [2493736]
  2. Nakhon Ratchasima Rajabhat University
  3. Faculty of Medical Technology, Prince of Songkla University

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The study identified Piper betle leaf ethanolic extract as having significant antibacterial activity against Staphylococcus aureus and Escherichia coli, inhibiting biofilm formation and promoting eradication. 4-Allyl-1,2-diacetoxybenzene and eugenol in the extract were found to play major roles in the antibacterial and anti-biofilm activity. These results suggest that ethanolic P. betle leaf extract shows promise as an alternative method for preventing bacterial diseases.
The emergence of drug-resistant bacteria has impacted the outcome of current therapeutics as a threat to global healthcare; novel medicines are urgently needed. Thirteen medicinal plants were collected in Northeastern Thailand, and their crude ethanolic extracts were evaluated for antibacterial activities against Staphylococcus aureus ATCC25923 and Escherichia coli ATCC25922 using the broth micro-dilution method. Piper betle leaf ethanolic extract showed optimal activity against both representative bacterial strains. Activity was also observed against clinical isolates of methicillin-resistant S. aureus (MRSA) and E. coli, with minimal inhibitory concentration (MIC) ranging from 0.31 mg/mL to 2.5 mg/mL and minimal bactericidal concentration (MBC) ranging from 0.62 mg/mL to 2.5 mg/mL. A time-kill study revealed that the extract activity was time- and dose-dependent, and also bactericidal on the tested bacteria. P. betle extract inhibited biofilm formation and promoted biofilm eradication in both S. aureus and E. coli. 4-Allyl-1,2-diacetoxybenzene and eugenol were identified as the most abundant compounds in the extract and may play major roles in the anti-bacterial and anti-biofilm activity. Results suggest that ethanolic P. betle leaf extract shows promise as an alternative method for the prevention of bacterial diseases.

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