期刊
ANTIBIOTICS-BASEL
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics10121481
关键词
methicillin-resistant S; aureus; biofilm; cloudberry; Rubus; ellagitannin
资金
- VTT Innovation program iBEX, Innovative Business to solve Exponential problems
- University of Helsinki
The study demonstrates that sanguiin H-6 fractionated from cloudberry seeds has significant inhibitory effect on MRSA and can be used as a preventive measure for surgical site infections. Conversely, lambertianin C did not show any anti-MRSA activity.
Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity.
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