期刊
ANTIBIOTICS-BASEL
卷 10, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics10111336
关键词
class 1 integron; foodborne pathogen; multilocus sequence typing; Salmonella enterica serovar Schwarzengrund
资金
- Livestock Promotional Funds of the Japan Racing Association
- Japanese Ministry of Health, Labor, and Welfare [H30-Shinkou-Ippan-006]
The study showed changes in antimicrobial resistance and molecular characteristics of Salmonella enterica serovar Schwarzengrund in chicken meat in Japan, indicating a connection between strains obtained from different locations and years, suggesting potential transmission among them.
Our previous study revealed that Salmonella enterica serovar Schwarzengrund-contaminated areas of broiler chickens have expanded from West Japan to East Japan. The present study investigated the antimicrobial resistance and molecular characteristics of 124 S. Schwarzengrund isolates obtained from chicken meat produced in East and West Japan from 2008 to 2019. Comparing the isolates obtained in 2008 and 2015-2019, an increase in the proportion of those resistant to kanamycin [51.4-89.7% (p < 0.001)] was observed. In contrast, the proportion of isolates resistant to both streptomycin and tetracycline and those that harbored a 1.0-kb class 1 integron, aadA1, and tetA, significantly decreased from 100% in 2008 to 47.1% in 2015-2019 (p < 0.001). A 1.0-kb class 1 integron containing aadA1, harbored by 78 isolates, was different from that reported in globally distributed S. Schwarzengrund strains (1.9 kb, containing the dfrA12-aadA2 gene cassette). Twenty-five isolates from different product districts and years of isolation were typed as sequence type (ST) 241 with multilocus sequence typing. Our results suggest that S. Schwarzengrund, which contaminates chicken meat in Japan, shares a common ancestor regardless of the product district from 2008 to recent years. Moreover, S. Schwarzengrund ST241 may have spread from western to eastern Japan.
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