期刊
ANTIBIOTICS-BASEL
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics10121552
关键词
antimicrobial sensitivity; Enterococcus spp; microbial infections; empiric therapy
Antimicrobial resistance is a major threat to healthy ecosystems, and Enterococcus species have received significant attention for their multidrug resistance in nosocomial infections. Studies have shown that Enterococcus exhibit high resistance levels to certain antibiotics, but are highly sensitive to tigecycline and vancomycin.
Antimicrobial resistance represents one of the main threats to healthy ecosystems. In recent years, among the multidrug-resistant microorganisms responsible for nosocomial infections, the Enterococcus species have received much attention. Indeed, Enterococcus have peculiar skills in their ability to acquire resistance genes and to cause severe diseases, such as endocarditis. This study showed the prevalence and antimicrobial resistance rate of Enterococcus spp. isolated from clinical samples, from January 2015 to December 2019 at the University Hospital San Giovanni di Dio e Ruggi d'Aragona in Salerno, Italy. A total of 3236 isolates of Enterococcus faecalis (82.2%) and Enterococcus faecium (17.8%) were collected from urine cultures, blood cultures, catheters, respiratory tract, and other samples. Bacterial identification and antibiotic susceptibility were performed with VITEK 2. E. faecium showed a high resistance rate against ampicillin (84.5%), ampicillin/sulbactam (82.7%), and imipenem (86.7%), while E. faecalis showed the highest resistance rate against gentamicin and streptomycin high level, but both were highly sensitive to such antibiotics as tigecycline and vancomycin. Studies of surveillance are an important tool to detect changes in the resistance profiles of the main pathogens. These antimicrobial susceptibility patterns are necessary to improve the empirical treatment guideline of infections.
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