期刊
CLINICAL KIDNEY JOURNAL
卷 15, 期 3, 页码 564-566出版社
OXFORD UNIV PRESS
DOI: 10.1093/ckj/sfab250
关键词
B lymphocytes; IgG4-related disease; kidney disease; membranous nephropathy
This case demonstrates that obinutuzumab can be successfully used in the treatment of membranous nephropathy associated with IgG4-related disease.
Immunoglobulin G4 (IgG4)-releated disease is typically associated with interstitial nephritis, but rare cases of idiopathic membranous nephropathy as a renal manifestation have been described. Obinutuzumab was successfully used in refractory membranous nephropathy, but evidence for the treatment of IgG4-related disease with obinutuzumab is lacking. We report one patient's case with membranous nephropathy associated with IgG4-related disease who was treated with obinutuzumab following an anaphylactic reaction to rituximab. Obinutuzumab treatment resulted in a sustained complete remission of membranous nephropathy and a decrease of IgG4 to the normal range. This case demonstrates that membranous nephropathy associated with IgG4-related disease can be treated successfully with obinutuzumab.
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