期刊
FOODS
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/foods10102306
关键词
diabetes; epigenetics; innate immune cells; microbiota; Omega-3 PUFA; venous leg ulcers; wound healing
资金
- Linea [Linea D.1 2019]
Long-chain Omega-3 polyunsaturated fatty acids are recognized as powerful regulators of acute inflammation, with potential applications in chronic pathologies. Current research focuses on their specific effects on wound healing, particularly in patients with diabetes or venous insufficiency, highlighting the mechanisms through which these compounds may act. Considerations on optimal dietary doses and future perspectives in this area are also discussed.
Long-chain Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) are widely recognized as powerful negative regulators of acute inflammation. However, the precise role exerted by these dietary compounds during the healing process is still largely unknown, and there is increasing interest in understanding their specific effects on the implicated cells/molecular factors. Particular attention is being focused also on their potential clinical application in chronic pathologies characterized by delayed and impaired healing, such as diabetes and vascular diseases in lower limbs. On these bases, we firstly summarized the current knowledge on wound healing (WH) in skin, both in normal conditions and in the setting of these two pathologies, with particular attention to the cellular and molecular mechanisms involved. Then, we critically reviewed the outcomes of recent research papers investigating the activity exerted by Omega-3 PUFAs and their bioactive metabolites in the regulation of WH in patients with diabetes or venous insufficiency and showing chronic recalcitrant ulcers. We especially focused on recent studies investigating the mechanisms through which these compounds may act. Considerations on the optimal dietary doses are also reported, and, finally, possible future perspectives in this area are suggested.
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