期刊
FOODS
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/foods10102478
关键词
polysaccharides; scallop skirt; gut microbiota; short-chain fatty acids; immune response
资金
- National Key Research and Development Program of China [2018YFD0901004]
- Key Science and Technology Program of Liaoning Province [2020JH1/10200001]
- Youth Breeding Project of Liaoning Province [QL202007]
- Dalian Science and Technology Bureau Program [2020RQ116]
The polysaccharide from Patinopecten yessoensis skirt (PS) was found to enhance immune response in mice by increasing serum IgG and IgM levels. Additionally, it modulated gut microbiota, improved SCFAs metabolism, and significantly affected gene expression in the TLR signaling pathway. These findings suggest the potential of PS as a functional ingredient for immune support products.
Polysaccharide from marine shellfish has various bioactivities. In this study, the effects of polysaccharide from Patinopecten yessoensis skirt (PS) on boosting immune response in mice were evaluated, and the potential mechanisms were explored. The results showed that PS administration effectively increased the serum IgG and IgM levels, implying that PS had immune response-boosting properties. Moreover, PS administration could modulate the composition of the gut microbiota, and significantly improve short-chain fatty acids (SCFAs) metabolism, especially butyrate metabolism. Of note, the expression of the Tlr2, Tlr7, MyD88, Tnfa, and Il1b genes in toll-like receptor (TLR) signaling pathway was significantly increased. In summary, PS could boost immune response by modulating the gut microbiota and SCFAs metabolism correlating with the activation of the TLR signaling pathway. Therefore, PS can be developed as a special ingredient for functional product.
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