Rapid Progression of Angioimmunoblastic T Cell Lymphoma Following BNT162b2 mRNA Vaccine Booster Shot: A Case Report

Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AITL.

Automated summary

Nucleoside-modified mRNA vaccines have a strong impact on T follicular helper cells, which may influence the development of neoplasms. This report discusses the unexpected rapid progression of lymphomatous lesions in a man diagnosed with AITL after receiving a BNT162b2 mRNA vaccine booster.