The Spectrum of Manifestations of Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV2) Infection in Children: What We Can Learn From Multisystem Inflammatory Syndrome in Children (MIS-C)

Letter Rheumatology

Response to: 'Correspondence on 'Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID19): a multicentre cohort'' by Mastrolia et al

Charlotte Borocco et al.

ANNALS OF THE RHEUMATIC DISEASES (2022)

Article Immunology

Multi-inflammatory Syndrome in Children Related to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Spain

Cinta Moraleda et al.

Summary: Clusters of children with MIS-C associated with SARS-CoV-2 infection have been reported in Spain. MIS-C is a potentially severe condition that presents in children with recent SARS-CoV-2 infection.

CLINICAL INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Virology

Multisystem inflammatory syndrome in children related to COVID-19: A New York City experience

Mariawy Riollano-Cruz et al.

Summary: Following the outbreak of the COVID-19 pandemic in 2020, children have been reported to develop a systemic inflammatory syndrome related to the virus. The pediatric patients mainly come from Hispanic/Latino and Black/African American backgrounds in New York City.

JOURNAL OF MEDICAL VIROLOGY (2021)

添加到收藏夹

Review Pediatrics

Multi-system inflammatory syndrome in children & adolescents (MIS-C): A systematic review of clinical features and presentation

Trisha Radia et al.

Summary: MIS-C, associated with Covid-19, shows higher incidence of gastrointestinal symptoms and severity, with the majority of cases requiring intensive care support.

PAEDIATRIC RESPIRATORY REVIEWS (2021)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Spectrum of Imaging Findings at Chest Radiography, US, CT, and MRI in Multisystem Inflammatory Syndrome in Children Associated with COVID-19

Shema Hameed et al.

Summary: This case series examines the imaging findings of children with multisystem inflammatory syndrome in children, including airway inflammation, pulmonary edema, coronary artery aneurysms, and abdominal inflammatory changes. Knowledge of this emerging condition and expected imaging findings will help radiologists in assessing these complex cases.

RADIOLOGY (2021)

添加到收藏夹

Article Rheumatology

Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort study

Jackeline J. Rodriguez-Smith et al.

Summary: Our findings demonstrate that MIS-C can be distinguished from Kawasaki disease primarily by elevated CXCL9 concentrations. Stratification of MIS-C patients by high or low CXCL9 concentrations suggests MAS-like pathophysiology in severe MIS-C cases, indicating new possibilities for diagnosis and treatment.

LANCET RHEUMATOLOGY (2021)

添加到收藏夹

Review Pediatrics

A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process

Rachel Harwood et al.

Summary: PIMS-TS is a newly discovered condition associated with COVID-19, and a national consensus management pathway has been developed for UK clinicians caring for affected children. The guidance emphasizes the importance of a multidisciplinary team in decision-making and recommends treatment options including supportive care, immunoglobulin, steroids, and biological therapies. This guidance provides a solid framework for clinicians caring for children with PIMS-TS in the UK and will be updated based on future evidence.

LANCET CHILD & ADOLESCENT HEALTH (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Acute Cardiovascular Manifestations in 286 Children With Multisystem Inflammatory Syndrome Associated With COVID-19 Infection in Europe

Israel Valverde et al.

Summary: The study documented cardiovascular clinical findings, cardiac imaging, and laboratory markers in children with multisystem inflammatory syndrome associated with COVID-19 infection. Most children in the study cohort had cardiac complications and significantly raised levels of inflammatory markers.

CIRCULATION (2021)

添加到收藏夹

Review Immunology

Dendritic cells in COVID-19 immunopathogenesis: insights for a possible role in determining disease outcome

Rodrigo Cerqueira Borges et al.

Summary: SARS-CoV-2, the novel coronavirus responsible for the COVID-19 pandemic, has spread rapidly worldwide affecting over 200 countries. Older individuals are more susceptible, and understanding the interaction between the immune system and the virus, as well as the role of dendritic cells during infection, is crucial for elucidating COVID-19 pathogenesis, risk factors, and development of effective therapies and vaccines.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2021)

添加到收藏夹

Article Rheumatology

American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 2

Lauren A. Henderson et al.

Summary: This article provides guidance on the management of Multisystem Inflammatory Syndrome in Children (MIS-C) and hyperinflammation in children with coronavirus disease 2019 (COVID-19). A multidisciplinary Task Force developed 40 guidance statements and a flow diagram for the diagnostic pathway of MIS-C.

ARTHRITIS & RHEUMATOLOGY (2021)

添加到收藏夹

Article Pediatrics

Multisystem Inflammatory Syndrome of Children: Subphenotypes, Risk Factors, Biomarkers, Cytokine Profiles, and Viral Sequencing

Roberta L. DeBiasi et al.

Summary: This study evaluated demographic, clinical, and biomarker features of patients with multisystem inflammatory syndrome in children (MIS-C), compared MIS-C sub-phenotypes, identified cytokine biosignatures, and characterized viral genome sequences. The results showed that Black and Latino children were over-represented in the MIS-C cohort, with Black children at greatest risk; cardiac complications were more frequent in critically ill patients with MIS-C.

JOURNAL OF PEDIATRICS (2021)

添加到收藏夹

Article Medicine, General & Internal

Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19

Leora R. Feldstein et al.

Summary: Comparing the clinical characteristics and outcomes of patients with MIS-C and COVID-19 can help distinguish between the two conditions and improve health outcomes. Patterns of clinical presentation and organ system involvement were identified in this case series, providing valuable information for differentiation of MIS-C and COVID-19.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

添加到收藏夹

Article Clinical Neurology

Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome

Kerri L. LaRovere et al.

Summary: This study investigated the range and severity of neurologic involvement among children and adolescents associated with COVID-19, revealing that many patients showed clinical symptoms, but mainly presented with transient symptoms. A small number of cases developed severe, and even life-threatening, neurologic conditions.

JAMA NEUROLOGY (2021)

添加到收藏夹

Article Immunology

Two Different Antibody-Dependent Enhancement (ADE) Risks for SARS-CoV-2 Antibodies

Darrell O. Ricke

Summary: The severity and stages of COVID-19 vary, with different pathological processes such as cytokine storms, ARDS, etc., and the development of related vaccines is hindered by vaccine-induced enhanced disease responses.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Pediatrics

Factors linked to severe outcomes in multisystem inflammatory syndrome in children (MIS-C) in the USA a retrospective surveillance study

Joseph Y. Abrams et al.

Summary: Factors such as age, race, clinical symptoms, and laboratory markers were found to be associated with severe outcomes in patients with MIS-C. These findings highlight the importance of early recognition and prompt management for patients with MIS-C.

LANCET CHILD & ADOLESCENT HEALTH (2021)

添加到收藏夹

Article Pediatrics

Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: results from a national, multicenter survey

Marco Cattalini et al.

Summary: The study indicates that SARS-CoV-2 infection can lead to two distinct inflammatory diseases in children: Kawasaki Disease and PIMS-TS. Older age and clinical peculiarities like myocarditis characterize this multi-inflammatory syndrome, with patients showing optimal response to treatments, few complications, and no deaths.

PEDIATRIC RHEUMATOLOGY (2021)

添加到收藏夹

Article Immunology

Plasmacytoid Dendritic Cells Depletion and Elevation of IFN-γ Dependent Chemokines CXCL9 and CXCL10 in Children With Multisystem Inflammatory Syndrome

Francesca Caldarale et al.

Summary: In children with COVID-19, there is an immune response suggestive of type I interferon activation, possibly due to recent interaction with the virus, while in MIS-C, the immune response is characterized by elevation of inflammatory cytokines/chemokines, which may contribute to the multisystem and cardiovascular damage observed in MIS-C.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Treatment of Multisystem Inflammatory Syndrome in Children

Andrew J. McArdle et al.

Summary: This international observational cohort study found no significant difference in the recovery from MIS-C after primary treatment with IVIG alone, IVIG plus glucocorticoids, or glucocorticoids alone, although significant differences may emerge as more data accrue.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Article Medicine, General & Internal

Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes

Mary Beth F. Son et al.

Summary: Initial treatment with IVIG plus glucocorticoids was associated with a lower risk of cardiovascular dysfunction compared to IVIG alone in children with MIS-C.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Editorial Material Pediatrics

Myocarditis After SARS-CoV-2 Vaccination: True, True, and ... Related?

Sean T. O'Leary et al.

PEDIATRICS (2021)

添加到收藏夹

Article Pediatrics

Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination

Mayme Marshall et al.

Summary: This report presents 7 cases of acute myocarditis or myopericarditis in healthy male adolescents following the second dose of Pfizer-BioNTech COVID-19 vaccination, with patients rapidly recovering their symptoms through treatment with nonsteroidal anti-inflammatory drugs, intravenous immunoglobulin, and corticosteroids. The potential association between vaccine administration and myocarditis requires further monitoring and investigation.

PEDIATRICS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children with severe myocarditis

Camille de Cevins et al.

Summary: The study reveals that the most severe forms of multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2 infection resulting in myocarditis are characterized by elevated levels of cytokines and chemokines, as well as a unique monocyte/dendritic cell gene signature correlated with sustained NF-κB activity and TNF-α signaling. This suggests a weak response to interferons, hyperinflammation, and increased response to oxidative stress related to HIF-1α and VEGF signaling.

MED (2021)

添加到收藏夹

Review Pediatrics

Revised recommendations of the Italian Society of Pediatrics about the general management of Kawasaki disease

Alessandra Marchesi et al.

Summary: The revised recommendations for the general management of Kawasaki disease aim to promote prompt recognition and appropriate therapy, based on scientific data, to raise awareness of complications related to misdiagnosis or delayed treatment. Following these recommendations should improve prognosis and prevent permanent vascular abnormalities in Kawasaki disease, reducing morbidity and mortality.

ITALIAN JOURNAL OF PEDIATRICS (2021)

添加到收藏夹

Article Immunology

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Stuart P. Weisberg et al.

Summary: This study found distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts showed a broader range of antibody responses, while children predominantly generated antibodies specific for the S protein and had reduced neutralizing activity compared to adults.

NATURE IMMUNOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

An autopsy study of the spectrum of severe COVID-19 in children: From SARS to different phenotypes of MIS-C

Amaro Nunes Duarte-Neto et al.

Summary: SARS-CoV-2 can infect multiple organs in pediatric patients, leading to different clinical manifestations. Severe COVID-19 in children can present as primarily pulmonary disease or as a multisystem inflammatory syndrome involving various organs. The presence of SARS-CoV-2 in different tissues suggests a direct effect on the pathogenesis of the disease.

ECLINICALMEDICINE (2021)

添加到收藏夹

Article Infectious Diseases

The clinical profile and outcomes of adult patients given intravenous colistin for multidrug-resistant gram negative infections in a Philippine tertiary hospital

Kingbherly L. Li et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

添加到收藏夹

Letter Medicine, General & Internal

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

Supinda Bunyavanich et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Review Virology

COVID-19 epidemic: Disease characteristics in children

Jiatong She et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

Hyperinflammatory shock in children during COVID-19 pandemic

Shelley Riphagen et al.

LANCET (2020)

添加到收藏夹

Article Medicine, General & Internal

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study

Lucio Verdoni et al.

LANCET (2020)

添加到收藏夹

Review Infectious Diseases

The state of vaccine safety science: systematic reviews of the evidence

Matthew Z. Dudley et al.

LANCET INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Infectious Diseases

Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series

Kathleen Chiotos et al.

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY (2020)

添加到收藏夹

Letter Medicine, General & Internal

Children with Covid-19 in Pediatric Emergency Departments in Italy

Niccolo Parri et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Letter Medicine, General & Internal

SARS-CoV-2 Infection in Children

Xiaoxia Lu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Pediatrics

Epidemiology of COVID-19 Among Children in China

Yuanyuan Dong et al.

PEDIATRICS (2020)

添加到收藏夹

Article Pediatrics

COVID-19 in Children and the Dynamics of Infection in Families

Klara M. Posfay-Barbe et al.

PEDIATRICS (2020)

添加到收藏夹

Article Infectious Diseases

SARS-CoV-2-related paediatric inflammatory multisystem syndrome, an epidemiological study, France, 1 March to 17 May 2020

Alexandre Belot et al.

EUROSURVEILLANCE (2020)

添加到收藏夹

Article Immunology

Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

Runhong Zhou et al.

IMMUNITY (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

COVID-19-Associated Multisystem Inflammatory Syndrome in Children - United States, March-July 2020

Shana Godfred-Cato et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

添加到收藏夹

Article Medicine, General & Internal

Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2

Elizabeth Whittaker et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Article Pediatrics

Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study

Patrick Davies et al.

LANCET CHILD & ADOLESCENT HEALTH (2020)

添加到收藏夹

Review Pediatrics

Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management

Natasha A. Nakra et al.

CHILDREN-BASEL (2020)

添加到收藏夹

Article Pediatrics

Characteristics, Cardiac Involvement, and Outcomes of Multisystem Inflammatory Disease of Childhood (MIS-C) Associated with SARS-CoV-2 Infection

Christine A. Capone et al.

JOURNAL OF PEDIATRICS (2020)

添加到收藏夹

Article Pediatrics

Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2 Infection (MIS-C): A Multi-institutional Study from New York City

Shubhi Kaushik et al.

JOURNAL OF PEDIATRICS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19

Camila Rosat Consiglio et al.

CELL (2020)

添加到收藏夹

Article Medicine, General & Internal

Multisystem Inflammatory Syndrome in US Children and Adolescents

Leora R. Feldstein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Medicine, General & Internal

Multisystem Inflammatory Syndrome in Children in New York State

Elizabeth M. Dufort et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Critical Care Medicine

Clinical Features of Critical Coronavirus Disease 2019 in Children

Samina Bhumbra et al.

PEDIATRIC CRITICAL CARE MEDICINE (2020)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Cardiac MRI in Children with Multisystem Inflammatory Syndrome Associated with COVID-19

Eleonore Blondiaux et al.

RADIOLOGY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS CoV-2

Caroline Diorio et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

添加到收藏夹

Review Immunology

COVID-19 Vaccines: Should We Fear ADE?

Scott B. Halstead et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Urology & Nephrology

Eculizumab treatment for renal failure in a pediatric patient with COVID-19

Ruchi Mahajan et al.

JOURNAL OF NEPHROLOGY (2020)

添加到收藏夹

Editorial Material Urology & Nephrology

COVID-19 and acute kidney injury in pediatric subjects: is there a place for eculizumab treatment?

Hernan Trimarchi et al.

JOURNAL OF NEPHROLOGY (2020)

添加到收藏夹

Article Pediatrics

Pediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Clinical Presentation, Infectivity, and Immune Responses

Lael M. Yonker et al.

JOURNAL OF PEDIATRICS (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Echocardiographic Findings in Pediatric Multisystem Inflammatory Syndrome Associated With COVID-19 in the United States

Daisuke Matsubara et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

添加到收藏夹

Article Hematology

Consensus-based clinical recommendations and research priorities for anticoagulant thromboprophylaxis in children hospitalized for COVID-19-related illness

Neil A. Goldenberg et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection

Michael J. Carter et al.

NATURE MEDICINE (2020)

添加到收藏夹

Editorial Material Medicine, General & Internal

Trained Innate Immunity, Epigenetics, and Covid-19

Alberto Mantovani et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Review Immunology

A Systematic Review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection

Ashlesha Kaushik et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2020)

添加到收藏夹

Article Medicine, General & Internal

Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study

Olivia Swann et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection - United Kingdom and United States, March-August 2020

Sapna Bamrah Morris et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

添加到收藏夹

Article Medicine, General & Internal

Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract

Miguel E. Ortiz et al.

EBIOMEDICINE (2020)

添加到收藏夹

Article Pediatrics

SARS-CoV-2 in cardiac tissue of a child with COVID-19-related multisystem inflammatory syndrome

Marisa Dolhnikoff et al.

LANCET CHILD & ADOLESCENT HEALTH (2020)

添加到收藏夹

Review Pediatrics

Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis-A Critical Review of Its Pathogenesis and Treatment

Jeremy C. McMurray et al.

FRONTIERS IN PEDIATRICS (2020)

添加到收藏夹

Article Infectious Diseases

Multisystem inflammatory syndrome in children (MIS-C): Report of the clinical and epidemiological characteristics of cases in Santiago de Chile during the SARS-CoV-2 pandemic

Juan P. Torres et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Critical Care Medicine

Severe manifestations of SARS-CoV-2 in children and adolescents: from COVID-19 pneumonia to multisystem inflammatory syndrome: a multicentre study in pediatric intensive care units in Spain

Alberto Garcia-Salido et al.

CRITICAL CARE (2020)

添加到收藏夹

Article Virology

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry

Yushun Wan et al.

JOURNAL OF VIROLOGY (2019)

添加到收藏夹

Article Microbiology

Dengue Antibody- Dependent Enhancement: Knowns and Unknowns

Scott B. Halstead

MICROBIOLOGY SPECTRUM (2014)

添加到收藏夹

Article Hematology

Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon

Luisa Cervantes-Barragan et al.

BLOOD (2007)

添加到收藏夹

Article Virology

DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus

A Marzi et al.

JOURNAL OF VIROLOGY (2004)

添加到收藏夹

The Spectrum of Manifestations of Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV2) Infection in Children: What We Can Learn From Multisystem Inflammatory Syndrome in Children (MIS-C)

相关参考文献

导出引文

分享论文