期刊
FRONTIERS IN MEDICINE
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2021.751529
关键词
lipotoxicity; tubular injury; diabetic kidney disease; primary event; lipid accumulation
资金
- National Natural Science Foundation of China
Research suggests that lipotoxicity plays a significant role in renal injury during the progression of diabetic nephropathy, primarily leading to glomerular dysfunction.
The pathogenesis of diabetic nephropathy is a complex process that has a great relationship with lipotoxicity. Since the concept of nephrotoxicity was proposed, many studies have confirmed that lipotoxicity plays a significant role in the progression of diabetic nephropathy and causes various renal dysfunction. This review will make a brief summary of renal injury caused by lipotoxicity that occurs primarily and predominantly in renal tubules during diabetic progression, further leading to glomerular dysfunction. The latest research suggests that lipotoxicity-mediated tubular injury may be a major event in diabetic nephropathy.
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