期刊
FRONTIERS IN MEDICINE
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2021.803929
关键词
membranous nephropathy; tertiary lymphoid organs; anti-phospholipase A2 receptor autoantibody; proteinuria; creatinine
资金
- International (regional) Cooperation and Exchange Projects (NSFC-DFG Grant) [81761138041]
- National Natural Science Foundation of China [81570667, 82100730]
- Major Research Plan of the National Natural Science Foundation of China [91742204]
- National Key R&D Program of China [2018YFC1314003-1]
This study demonstrates the prevalence of TLOs in patients with MN and shows that patients with MN with TLOs have worse clinical manifestation and outcomes compared to patients without TLOs. Furthermore, the presence of TLOs is associated with specific clinical features and positive antibody status, highlighting their importance in MN.
BackgroundTertiary lymphoid organs play an essential role in the inflammation of the kidney. The clinical association between TLOs and membranous nephropathy (MN) is not clear yet. MethodsConsecutive patients with the histologically confirmed membranous nephropathy in Tongji Hospital from July 19, 2012, to September 26, 2019, were included in this study. TLOs in renal biopsy tissues were detected by periodic acid-Schiff-stained and immunohistochemistry. Logistic regression was performed to evaluate the correlations of TLOs and clinical features of patients with MN. Kaplan-Meier analysis was utilized to examine the relationship between TLOs and remission of proteinuria. ResultsA total of 442 patients with MN were included in this study, of which the average age was 46.4 years old, and 58.8% were male. Moreover, 33% of patients with MN had TLOs in this study. The median value of proteinuria among patients with MN with TLOs was 4.9 g/24 h, which was much greater than no-TLOs ones (3.2 g/24 h, p < 0.001). Moreover, the patients with TLOs had higher serum creatinine and lower serum albumin. The severity of clinical features among the patients with MN aggravated with the increase in the grade of TLOs. In addition, the patients who had TLOs were more likely to be positive of anti-phospholipase A2 receptor autoantibodies. Meanwhile, the patients without TLOs showed significantly higher complete remission and total remission of proteinuria. ConclusionIn this study, we demonstrated that TLOs were common among patients with MN. Moreover, the patients with MN with TLOs showed a worse clinical manifestation and an outcome compared with the patients without TLOs.
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