Metabolomics, Microbiota, and In Vivo and In Vitro Biomarkers in Type 2 Severe Asthma: A Perspective Review

Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient; thus, it could be a new approach for the management of severe asthma that considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events. Metabolomics is the systematic study of low molecular weight (bio)chemicals in a given biological system and offers a powerful approach to biomarker discovery and elucidating disease mechanisms. In this point of view, metabolomics could play a key role in targeting precision medicine.

Automated summary

Precision medicine tailors therapeutic strategies to individual characteristics, aiding in the selection of treatment and timing for maximal efficacy and minimum adverse events. Metabolomics, by studying low molecular weight chemicals in biological systems, offers a powerful tool for biomarker discovery and understanding disease mechanisms, potentially playing a key role in precision medicine.