期刊
PATHOGENS
卷 10, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/pathogens10111369
关键词
coffee pulp; chlorogenic acid; obesity; metabolic syndrome; high-carbohydrate; high-fat; gut microbiota
类别
资金
- University of Southern Queensland Research and Innovation Division [SRF-09]
The study found that supplementing the diet with freeze-dried coffee pulp can improve symptoms of metabolic syndrome induced by high-carbohydrate, high-fat diet, reduce body weight, improve cardiovascular health and liver function, and modulate gut microbiota.
Waste from food production can be re-purposed as raw material for usable products to decrease industrial waste. Coffee pulp is 29% of the dry weight of coffee cherries and contains caffeine, chlorogenic acid, trigonelline, diterpenes and fibre. We investigated the attenuation of signs of metabolic syndrome induced by high-carbohydrate, high-fat diet in rats by dietary supplementation with 5% freeze-dried coffee pulp for the final 8 weeks of a 16-week protocol. Coffee pulp decreased body weight, feed efficiency and abdominal fat; normalised systolic blood pressure, left ventricular diastolic stiffness, and plasma concentrations of triglycerides and non-esterified fatty acids; and improved glucose tolerance in rats fed high-carbohydrate, high-fat diet. Further, the gut microbiota was modulated with high-carbohydrate, high-fat diet and coffee pulp supplementation and 14 physiological parameters were correlated with the changes in bacterial community structures. This study suggested that coffee pulp, as a waste from the coffee industry, is useful as a functional food for improving obesity-associated metabolic, cardiovascular and liver structure and function, and gut microbiota.
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