期刊
PATHOGENS
卷 11, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/pathogens11020269
关键词
post-acute sequelae of COVID-19; long-COVID; prevalence; symptom; meta-analysis
类别
资金
- PHOSP-COVID grant from UK Research and Innovation
- National Institute of Health Research [MR/V027859/1, COV0319]
- Chief Scientist Office of the Scottish Government [COV/LTE/20/15]
- UK Research and Innovation
Emerging evidence suggests that COVID-19 survivors may experience persistent symptoms for at least 12 months, including fatigue, dyspnea, arthromyalgia, depression, anxiety, memory loss, concentration difficulties, and insomnia. Female patients and those with more severe initial illness are more likely to suffer from long-term sequelae after one year.
Emerging evidence has shown that COVID-19 survivors could suffer from persistent symptoms. However, it remains unclear whether these symptoms persist over the longer term. This study aimed to systematically synthesise evidence on post-COVID symptoms persisting for at least 12 months. We searched PubMed and Embase for papers reporting at least one-year follow-up results of COVID-19 survivors published by 6 November 2021. Random-effects meta-analyses were conducted to estimate pooled prevalence of specific post-COVID symptoms. Eighteen papers that reported one-year follow-up data from 8591 COVID-19 survivors were included. Fatigue/weakness (28%, 95% CI: 18-39), dyspnoea (18%, 95% CI: 13-24), arthromyalgia (26%, 95% CI: 8-44), depression (23%, 95% CI: 12-34), anxiety (22%, 95% CI: 15-29), memory loss (19%, 95% CI: 7-31), concentration difficulties (18%, 95% CI: 2-35), and insomnia (12%, 95% CI: 7-17) were the most prevalent symptoms at one-year follow-up. Existing evidence suggested that female patients and those with more severe initial illness were more likely to suffer from the sequelae after one year. This study demonstrated that a sizeable proportion of COVID-19 survivors still experience residual symptoms involving various body systems one year later. There is an urgent need for elucidating the pathophysiologic mechanisms and developing and testing targeted interventions for long-COVID patients.
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