4.5 Article

Prevalence, Genetic Structure and Antifungal Susceptibility of the Cryptococcus neoformans/C. gattii Species Complex Strains Collected from the Arboreal Niche in Poland

期刊

PATHOGENS
卷 11, 期 1, 页码 -

出版社

MDPI
DOI: 10.3390/pathogens11010008

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Cryptococcus neoformans/C. gattii species complex; environmental; arboreal; RFLP; MALDI-TOF MS; susceptibility

资金

  1. Wroclaw Centre of Biotechnology programme, The Leading National Research Centre (KNOW) [1/PB/2016/KNOW]

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Fungi belonging to the Cryptococcus neoformans/C. gattii species complex are serious and potentially fatal pathogens that mainly inhabit trees. Global epidemiological surveys have been conducted, but data is lacking in certain regions like Central and Eastern Europe. This study in Poland detected CNGSC strains in 2.2% of tested trees, consisting exclusively of C. neoformans. No resistance to commonly used antimycotics was found, except for some strains showing non-wild type resistance to 5-fluorocytosine.
Fungi belonging to the Cryptococcus neoformans/C. gattii species complex (CNGSC) are etiological agents of serious and not infrequently fatal infections in both humans and animals. Trees are the main ecological niche and source of potential exposition concerning these pathogens. With regard to epidemiology of cryptococcosis, various surveys were performed worldwide, enabling the establishment of a map of distribution and genetic structure of the arboreal population of the CNGSC. However, there are regions, among them Central and Eastern Europe, in which the data are lacking. The present study shows the results of such an environmental study performed in Wroclaw, Poland. The CNGSC strains were detected in 2.2% of the tested trees belonging to four genera. The obtained pathogen population consisted exclusively of C. neoformans, represented by both the major molecular type VNI and VNIV. Within the tested group of isolates, resistance to commonly used antimycotics was not found, except for 5-fluorocytosine, in which about 5% of the strains were classified as a non-wild type.

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