期刊
PATHOGENS
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/pathogens10121637
关键词
hepeviridae; rabbits; genomic epidemiology; seroepidemiology; Luminex; serology; whole-genome sequencing
类别
资金
- Meat and Livestock Australia [P01-B-002]
- CSIRO
- Centre for Invasive Species Solutions [P01-B-002]
- FeralScan/RabbitScan [P01-E-008]
- Invasive Animals Cooperative Research Centre [3.L.1c]
- [P.PSH.1059]
In 2020, Hepatitis E virus (HEV) was detected for the first time in Australian rabbits, showing a wide distribution and genetic diversity in rabbit populations across Australia. Phylogenetic analyses revealed that Australian HEV sequences are genetically diverse and were likely introduced independently multiple times.
In 2020, Hepatitis E virus (HEV) was detected for the first time in Australian rabbits. To improve our understanding of the genetic diversity and distribution of the virus, 1635 rabbit liver samples from locations across Australia were screened via RT-qPCR for HEV. HEV genomes were amplified and sequenced from 48 positive samples. Furthermore, we tested 380 serum samples from 11 locations across Australia for antibodies against HEV. HEV was detected in rabbits from all states and territories, except the Northern Territory. Seroprevalence varied between locations (from 0% to 22%), demonstrating that HEV is widely distributed in rabbit populations across Australia. Phylogenetic analyses showed that Australian HEV sequences are genetically diverse and that HEV was likely introduced into Australia independently on several occasions. In summary, this study broadens our understanding of the genetic diversity of rabbit HEV globally and shows that the virus is endemic in both domestic and wild rabbit populations in Australia.
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