Morphological Characteristics of Alveolar and Cystic Echinococcosis Lesions in Human Liver and Bone

Among echinococcoses diseases of human interest, two have a global public health impact: cystic and alveolar echinococcosis caused by Echinococcus granulosus sensu lato and Echinococcus multilocularis, respectively. Cystic and alveolar echinococcosis are neglected infectious diseases epidemiologically and are clinically vastly different with distinct microscopic features. Because of the rareness of these zoonotic diseases, pathologists have limited diagnostic experience in the analysis of the lesions caused by Echinococcus tapeworms. Here, we describe the main microscopic features to be considered to characterize these lesions: laminated layer, central necrosis, growth pattern, and delineation from adjacent tissue. Moreover, immunohistology using monoclonal antibodies is of great diagnostic help in reaching a definitive diagnosis by identifying the laminated body and small particles of E. multilocularis (spems) and small particles of E. granulosus (spegs).

Automated summary

Cystic and alveolar echinococcosis, caused by Echinococcus granulosus and Echinococcus multilocularis, are two neglected infectious diseases with distinct microscopic features and global public health impact. Pathologists have limited diagnostic experience due to the rarity of these zoonotic diseases, making immunohistology using monoclonal antibodies essential for definitive diagnosis.