LncRNA-MCM3AP-AS1 Promotes the Progression of Infantile Hemangiomas by Increasing miR-138-5p/HIF-1α Axis-Regulated Glycolysis

Review Dermatology

Repurposing Ophthalmologic Timolol for Dermatologic Use: Caveats and Historical Review of Adverse Events

Daniel J. Yoon et al.

Summary: There are no published guidelines for the use of timolol in dermatologic applications in adults, and clinicians need to be alert to potential adverse events, particularly those that have been documented prior to widespread use.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2021)

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Article Oncology

Curcumin suppresses renal carcinoma tumorigenesis by regulating circ-FNDC3B/miR-138-5p/IGF2 axis

Li Xue et al.

Summary: The study revealed that curcumin could suppress renal carcinoma cell proliferation and promote apoptosis by regulating the circ-FNDC3B/miR-138-5p/IGF2 axis, ultimately reducing the incidence of renal carcinoma. Moreover, in vivo experiments also confirmed that curcumin could decrease xenograft tumor growth.

ANTI-CANCER DRUGS (2021)

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Article Biochemistry & Molecular Biology

Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto's Thyroiditis

Michael Hepp et al.

Summary: The study found that oxidative stress in Hashimoto's thyroiditis results from an increase in reactive oxygen species and a decrease in antioxidant defenses. Moreover, oxidative stress leads to abnormal expression of several proteins, potentially exacerbating the pathophysiology of the disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

The Roles of HIF-1α in Radiosensitivity and Radiation-Induced Bystander Effects Under Hypoxia

Jianghong Zhang et al.

Summary: The study revealed that radiation-induced bystander effects significantly impact the radiation damage of hypoxic tumor cells, with irradiated hepatoma and glioblastoma cells showing reduced radiosensitivity under hypoxia by increasing HIF-1 alpha expression.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Veterinary Sciences

Metabolic Reprogramming and Inflammatory Response Induced by D-Lactate in Bovine Fibroblast-Like Synoviocytes Depends on HIF-1 Activity

John Quiroga et al.

Summary: Acute ruminal acidosis (ARA) in cattle leads to lameness, laminitis, and aseptic polysynovitis; fibroblast-like synoviocytes (FLS) play a crucial role in joint diseases and may release pro-inflammatory cytokines.

FRONTIERS IN VETERINARY SCIENCE (2021)

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Article Biochemistry & Molecular Biology

Photothermal Responsive Singlet Oxygen Nanocarriers for Hypoxic Cancer Cell Ablation

Ting Zhu et al.

Summary: A small-molecule dye-based O-1(2) capturing agent, B1, has been proposed to address the oxygen-independent generation of singlet oxygen for efficient cancer phototherapy. Stable B1-SO containing micelles (B1-SO NPs) have shown efficient cytotoxicity under near-infrared irradiation, especially in a hypoxic environment, suggesting their potential as novel cancer phototherapy agents.

CHEMBIOCHEM (2021)

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Article Oncology

Hypoxic tumor-derived exosomal miR-31-5p promotes lung adenocarcinoma metastasis by negatively regulating SATB2-reversed EMT and activating MEK/ERK signaling

Fengqiang Yu et al.

Summary: Exosomal miR-31-5p derived from hypoxic LUAD cells plays a crucial role in promoting tumor progression by targeting specific genes and signaling pathways. Higher levels of circulating exosomal miR-31-5p were detected in LUAD patients, particularly those with metastatic disease, suggesting its potential as a diagnostic biomarker for LUAD.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

A HIF1α-GPD1 feedforward loop inhibits the progression of renal clear cell carcinoma via mitochondrial function and lipid metabolism

Ren Liu et al.

Summary: In clear cell renal cell carcinoma (ccRCC), HIF1 alpha inhibits mitochondrial function and lipid metabolism by directly regulating GPD1, thus impacting tumor activity. This study provides new insights into the treatment of ccRCC and reveals a novel mechanism for the molecular basis of HIF1 alpha inhibition of tumor activity.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Letter Gastroenterology & Hepatology

Hypoxia is a key regulator in liver cancer progression

Lichun Ma et al.

JOURNAL OF HEPATOLOGY (2021)

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Article Medicine, Research & Experimental

被撤回的出版物: Pancreatic cancer cells-derived exosomal long non-coding RNA CCAT1/microRNA-138-5p/HMGA1 axis promotes tumor angiogenesis (Retracted article. See vol. 319, 2023)

Wei Han et al.

Summary: The study reveals that exosomal CCAT1 derived from PANC-1 cells enhances angiogenesis of HUVECs by regulating the miR-138-5p/HMGA1 axis.

LIFE SCIENCES (2021)

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Article Materials Science, Biomaterials

Side-Chain Selenium-Grafted Polymers Combining Antiangiogenesis Treatment with Photodynamic Therapy and Chemotherapy

Chenxing Sun et al.

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Medicine, Research & Experimental

Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B

Jing Xun et al.

Summary: This study demonstrates that miR-138-5p delivered from breast cancer cells to tumor-associated macrophages via exosomes can downregulate KDM6B expression, inhibit M1 polarization, and stimulate M2 polarization, ultimately promoting tumor metastasis. Additionally, exosomal miR-138-5p levels positively correlate with the progression of breast cancer, suggesting it as a potential prognostic marker and therapeutic target.

THERANOSTICS (2021)

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Review Oncology

microRNAs: New-Age Panacea in Cancer Therapeutics

Neelanjana Sarkar et al.

Summary: MiRNAs are small non-coding RNAs that play a crucial role in regulating gene expression. Dysregulated expression of miRNAs in human cancers can affect tumor development through various mechanisms.

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Molecular analysis of HIF activation as a potential biomarker for adverse reaction to metal debris (ARMD) in tissue and blood samples

Agata Nyga et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2019)

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Article Medicine, Research & Experimental

被撤回的出版物: Silence of long non-coding RNA UCA1 inhibits hemangioma cells growth, migration and invasion by up-regulation of miR-200c (Retracted article. See vol. 298, 2022)

Jing Zhang et al.

LIFE SCIENCES (2019)

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Article Biochemistry & Molecular Biology

A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis

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MOLECULAR CANCER (2019)

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Article Medicine, Research & Experimental

FOXM1-Mediated LINC-ROR Regulates the Proliferation and Sensitivity to Sorafenib in Hepatocellular Carcinoma

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MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

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Long noncoding RNA LINC00342 promotes growth of infantile hemangioma by sponging miR-3619-5p from HDGF

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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

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LncRNA MCM3AP-AS1 Regulates Epidermal Growth Factor Receptor and Autophagy to Promote Hepatocellular Carcinoma Metastasis by Interacting with miR-455

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Article Medicine, Research & Experimental

被撤回的出版物: lncRNA GAS5 Inhibits Cell Migration and Invasion and Promotes Autophagy by Targeting miR-222-3p via the GAS5/PTEN-Signaling Pathway in CRC (Retracted article. See vol. 30, pg. 510, 2022)

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MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

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Article Biochemistry & Molecular Biology

Long non-coding RNA MCM3AP-AS1 promotes growth and migration through modulating FOXK1 by sponging miR-138-5p in pancreatic cancer

Ming Yang et al.

MOLECULAR MEDICINE (2019)

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Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia

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LncRNA MCM3AP-AS1 promotes proliferation and invasion through regulating miR-211-5p/SPARC axis in papillary thyroid cancer

Meihua Liang et al.

ENDOCRINE (2019)

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Article Cell Biology

Effect of the LncRNA GAS5-MiR-23a-ATG3 Axis in Regulating Autophagy in Patients with Breast Cancer

Juan Gu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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被撤回的出版物: The Effect of MCM3AP-AS1/miR-211/KLF5/AGGF1 Axis Regulating Glioblastoma Angiogenesis (Retracted article. See vol. 16, 2023)

Chunqing Yang et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

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Review Endocrinology & Metabolism

The role of hypoxia-inducible factors in metabolic diseases

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NATURE REVIEWS ENDOCRINOLOGY (2018)

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Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis

Y. Zhang et al.

ONCOGENE (2017)

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Article Biochemistry & Molecular Biology

Histone demethylase JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of hypoxia inducible factor 1α

W. Wan et al.

ONCOGENE (2017)

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MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42

Jinjiang Chou et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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Infantile hemangiomas, complications and treatments

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SEMINARS IN CUTANEOUS MEDICINE AND SURGERY (2016)

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Risk Factors for Degree and Type of Sequelae After Involution of Untreated Hemangiomas of Infancy

Eulalia Baselga et al.

JAMA DERMATOLOGY (2016)

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Article Pediatrics

Diagnosis and Management of Infantile Hemangioma

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PEDIATRICS (2015)

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Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats

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JOURNAL OF PHYSIOLOGY-LONDON (2014)

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Article Dermatology

Propranolol-resistant infantile haemangiomas

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BRITISH JOURNAL OF DERMATOLOGY (2013)

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MicroRNA: Function, Detection, and Bioanalysis

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CHEMICAL REVIEWS (2013)

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Review Cell Biology

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CURRENT OPINION IN GENETICS & DEVELOPMENT (2011)

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Chromatin-modifying drugs induce miRNA-153 expression to suppress Irs-2 in glioblastoma cell lines

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miR-34c is downregulated in prostate cancer and exerts tumor suppressive functions

Zandra Hagman et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

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Article Pediatrics

Growth characteristics of infantile hemangiomas: Implications for management

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PEDIATRICS (2008)

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Article Hematology

Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin

Zia A. Khan et al.

BLOOD (2006)

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LncRNA-MCM3AP-AS1 Promotes the Progression of Infantile Hemangiomas by Increasing miR-138-5p/HIF-1α Axis-Regulated Glycolysis

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