4.3 Article

Preoperative prediction of gastrointestinal stromal tumors with high Ki-67 proliferation index based on CT features

期刊

ANNALS OF TRANSLATIONAL MEDICINE
卷 9, 期 20, 页码 -

出版社

AME PUBL CO
DOI: 10.21037/atm-21-4669

关键词

Gastrointestinal stromal tumors (GIST); Ki-67 proliferation index (Ki-67 PI); computed tomography (CT); imaging features

资金

  1. National Nature Science Foundations of China [82001810]
  2. 1.3.5 project for disciplines of the Excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University [19HXFH054]

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Preoperative CT features can be used to predict GISTs with a high Ki-67 proliferation index. Imaging features such as wall thickness, necrosis, and HYOM were significant predictors for GISTs with high Ki-67 PI.
Background: To determine whether preoperative computed tomography (CT) features can be used for the prediction of gastrointestinal stromal tumors (GISTs) with a high Ki-67 proliferation index (Ki-67 PI). Methods: A total of 198 patients with surgically and pathologically proven GISTs were retrospectively included. All GISTs were divided into a low Ki-67 PI group (<10%) and a high Ki-67 PI group (>= 10%). All imaging features were blindly interpreted by two radiologists. Receiver operating characteristic (ROC) curve analyses were conducted to evaluate the predictive performance of the imaging features. Results: Imaging features were found to be significantly different between the low and the high Ki-67 PI groups (P<0.05). Wall thickness of necrosis showed the highest predictive ability, with an area under the curve (AUC) of 0.838 [95% confidence interval (CI): 0.627-0.957], followed by necrosis, necrosis degree, hyperenhancement of the overlying mucosa (HYOM), and long diameter (LD) (AUC >0.7, P<0.05). HYOM was the strongest predictive feature for the high Ki-67 PI GISTs group, with an odds ratio (OR) value of 30.037 (95% CI: 5.707-158.106). Conclusion: Imaging features, including the presence of necrosis, high necrosis degree, thick wall of necrosis, and HYOM were significant predictive indicators for the high Ki-67 PI GISTs group.

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