期刊
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
卷 32, 期 4, 页码 414-420出版社
WILEY
DOI: 10.1002/gps.4483
关键词
aged; dementia; psychotropic drugs; Sweden
资金
- Swedish Research Council
ObjectiveTo investigate whether psychotropics are associated with an increased risk of fall injuries, hospitalizations, and mortality in a large general population of older adults. MethodsWe performed a nationwide matched (age, sex, and case event day) case-control study between 1 January and 31 December 2011 based on several Swedish registers (n=1,288,875 persons aged 65years). We used multivariate conditional logistic regression adjusted for education, number of inpatient days, Charlson co-morbidity index, dementia and number of other drugs. ResultsAntidepressants were the psychotropic most strongly related to fall injuries (ORadjusted: 1.42; 95% CI: 1.38-1.45) and antipsychotics to hospitalizations (ORadjusted: 1.22; 95% CI: 1.19-1.24) and death (ORadjusted: 2.10; 95% CI: 2.02-2.17). Number of psychotropics was associated with increased the risk of fall injuries, (4 psychotropics vs 0: ORadjusted: 1.53; 95% CI: 1.39-1.68), hospitalization (4 psychotropics vs 0: ORadjusted: 1.27; 95% CI: 1.22-1.33) and death (4 psychotropics vs 0: ORadjusted: 2.50; 95% CI: 2.33-2.69) in a dose-response manner. Among persons with dementia (n=58,984), a dose-response relationship was found between number of psychotropics and mortality risk (4 psychotropics vs 0: ORadjusted: 1.99; 95% CI: 1.76-2.25). ConclusionsOur findings support a cautious prescribing of multiple psychotropic drugs to older patients. (c) 2016 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons, Ltd.
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