期刊
MICROORGANISMS
卷 9, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms9102086
关键词
exopolysaccharide; colitis; inflammation; intestinal barrier; gut microbiota; short-chain fatty acids
类别
资金
- Scientific and Technological Project of Henan Province of China [182102311039]
- National Natural Science Foundation of China [32101919]
- Natural Science Foundation of Heilongjiang Province [YQ2020C013]
- China Postdoctoral Science Foundation [2021T140106, 2021M690580]
The study demonstrated that EPS-1 significantly alleviated the damage caused by DSS-induced UC by reducing intestinal inflammation, improving mucosal barrier function, and modulating gut microbiota composition.
Ulcerative colitis (UC) is a non-specific chronic inflammatory disease with lesions located in the colon and rectum. The aim of this study was to evaluate the anti-inflammatory effects of exopolysaccharide-1 (EPS-1) isolated by L. helveticus KLDS1.8701 on UC. The anti-inflammatory effects of EPS-1 were studied using dextran sulphate sodium (DSS)-induced UC model. In vivo results showed that EPS-1 administration significantly ameliorated weight loss, colon shortening, disease activity index (DAI) score, myeloperoxidase (MPO) activity, and colon tissue damage. In addition, EPS-1 administration significantly decreased the levels of pro-inflammatory cytokines and increased levels of anti-inflammatory cytokines. Meanwhile, EPS-1 administration significantly up-regulated the expression of tight junction proteins and mucin. Furthermore, EPS-1 administration modulated gut microbiota composition caused by DSS and increased the short-chain fatty acids (SCFAs) levels. Collectively, our study showed the alleviative effects of EPS- isolated by L. helveticus KLDS1.8701 on DSS-induced UC via alleviating intestinal inflammation, improving mucosal barrier function, and modulating gut microbiota composition.
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