Targeting of Regulators as a Promising Approach in the Search for Novel Antimicrobial Agents

Since the discovery of penicillin in the first half of the last century, antibiotics have become the pillars of modern medicine for fighting bacterial infections. However, pathogens resistant to antibiotic treatment have increased in recent decades, and efforts to discover new antibiotics have decreased. As a result, it is becoming increasingly difficult to treat bacterial infections successfully, and we look forward to more significant efforts from both governments and the scientific community to research new antibacterial drugs. This perspective article highlights the high potential of bacterial transcriptional and posttranscriptional regulators as targets for developing new drugs. We highlight some recent advances in the search for new compounds that inhibit their biological activity and, as such, appear very promising for treating bacterial infections.

Automated summary

Since the discovery of penicillin, antibiotics have played a crucial role in fighting bacterial infections but the rise of antibiotic-resistant pathogens has made it increasingly difficult to treat these infections. This article highlights the potential of bacterial transcriptional and posttranscriptional regulators as targets for developing new drugs and discusses recent advances in finding compounds that can inhibit their biological activity.