4.6 Article

Simvastatin Resistance of Leishmania amazonensis Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors

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Summary: Leishmania parasites, which cause leishmaniasis, do not synthesize cholesterol, but instead make ergostane-based sterols. Inactivation of the key enzyme C-14-demethylase in sterol biosynthesis leads to various defects, including impaired RNA stability and translation. Therefore, sterol biosynthesis in Leishmania unexpectedly plays a crucial role in global gene regulation.

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