☆ 4.6 Article

Prion-like Domains in Spike Protein of SARS-CoV-2 Differ across Its Variants and Enable Changes in Affinity to ACE2

MICROORGANISMS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Multidisciplinary Sciences

Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant

Baisheng Li et al.

Summary: This article reports the first local transmission of the Delta variant in mainland China. Compared to A/B lineage infections during the first wave in China in early 2020, Delta infections had viral loads that were on average about 1000 times greater when they first tested positive, suggesting potentially faster viral replication and greater infectiousness during early infection. The transmission bottleneck size of the Delta variant was generally narrow, with 1-3 virions in most donor-recipient transmission pairs. However, transmission of minor intra-host variants resulted in at least 3 of the 34 substitutions identified in the outbreak, highlighting the contribution of intra-host variants to population-level viral diversity during rapid spread.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Biology

Interactions of the Receptor Binding Domain of SARS-CoV-2 Variants with hACE2: Insights from Molecular Docking Analysis and Molecular Dynamic Simulation

Ismail Celik et al.

Summary: Since the COVID-19 pandemic began in late 2019, SARS-CoV-2 has continuously evolved, giving rise to multiple variants. Through protein-protein interaction studies, we investigated how five SARS-CoV-2 variants interact with the hACE2 receptor in host cells, finding that these variations impact the binding of the spike protein to hACE2.

BIOLOGY-BASEL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Dynamics and electrostatics define an allosteric druggable site within the receptor-binding domain of SARS-CoV-2 spike protein

Sayan Bhattacharjee et al.

Summary: The pathogenesis of SARS-CoV-2 virus involves recognition of host cells' ACE2 receptor by the RBD on the virus spikes. Molecular dynamics simulations show allosteric crosstalk within the RBD, influenced by correlated motions and electrostatic energy perturbations. This communication pathway is evolutionarily conserved among related coronaviruses, suggesting potential as a target for drug development.

FEBS LETTERS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England

Nicholas G. Davies et al.

Summary: A new variant of SARS-CoV-2 has emerged in England, with a higher reproduction number and potential for large resurgences of COVID-19 cases. Without stringent control measures, it is projected that COVID-19 hospitalizations and deaths in England for the first 6 months of 2021 will exceed those in 2020. The variant has spread globally and exhibited similar transmission increases in Denmark, Switzerland, and the United States.

SCIENCE (2021)

添加到收藏夹

Review Microbiology

SARS-CoV-2 Disease Adjuvant Therapies and Supplements Breakthrough for the Infection Prevention

Alessio Danilo Inchingolo et al.

Summary: This study evaluated the effect of adjuvant therapies and supplements for SARS-CoV-2 infection, with some substances showing significant benefits for improving the immune system, acting as potential inhibitor molecules, and enhancing the prognosis of long hauler patients.

MICROORGANISMS (2021)

添加到收藏夹

Article Cell Biology

Higher infectivity of the SARS-CoV-2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data

Abbas Khan et al.

Summary: The new variants of SARS-CoV-2 are more contagious and require further investigation on their interaction with the host receptor to identify new therapeutic options. Specific mutations in the Spike glycoprotein of the new variants may play a critical role in their unique pathogenicity.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Preliminary Structural Data Revealed That the SARS-CoV-2 B.1.617 Variant's RBD Binds to ACE2 Receptor Stronger Than the Wild Type to Enhance the Infectivity

Abbas Khan et al.

Summary: The evolution of SARS-CoV-2 variants has heightened concerns over the COVID-19 pandemic, necessitating an in-depth analysis to understand their impact on host receptors. Research shows that the B.1.617 variant exhibits different dynamic behaviors and structural properties.

CHEMBIOCHEM (2021)

添加到收藏夹

Review Genetics & Heredity

The biological and clinical significance of emerging SARS-CoV-2 variants

Kaiming Tao et al.

Summary: The emergence of multiple SARS-CoV-2 variants has significant impacts on the epidemiological and clinical aspects of the COVID-19 pandemic, including increased virus transmission rates, heightened risk of reinfection, and reduced effectiveness of neutralizing antibodies and vaccines. These variants have introduced new challenges to COVID-19 research, necessitating additional avenues of laboratory, epidemiological, and clinical studies.

NATURE REVIEWS GENETICS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Prion-like proteins: from computational approaches to proteome-wide analysis

Marcos Gil-Garcia et al.

Summary: Computational tools have been developed to identify prion-like proteins in different species, showing that the prion phenomenon is well conserved. These proteins are not only linked to the formation of protein-nucleic acid coacervates, but also associated with human diseases.

FEBS OPEN BIO (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

The SARS-CoV-2 B.1.618 variant slightly alters the spike RBD-ACE2 binding affinity and is an antibody escaping variant: a computational structural perspective

Abbas Khan et al.

Summary: The new SARS-CoV-2 variant B.1.618, with mutations in the RBD and NTD, shows increased pathogenicity and decreased affinity to monoclonal antibodies. Further studies are needed to develop effective therapies for this antibody-escaping variant.

RSC ADVANCES (2021)

添加到收藏夹

Review Immunology

The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

Hussin A. Rothan et al.

JOURNAL OF AUTOIMMUNITY (2020)

添加到收藏夹

Editorial Material Medicine, General & Internal

Defining the Epidemiology of Covid-19-Studies Needed

Marc Lipsitch et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Renhong Yan et al.

SCIENCE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

添加到收藏夹

Article Virology

Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV

Jiabao Xu et al.

VIRUSES-BASEL (2020)

添加到收藏夹

Article Immunology

The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines

Weilong Shang et al.

NPJ VACCINES (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Bacterial DNA promotes Tau aggregation

George Tetz et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Immunology

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

Wanbo Tai et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

Jasper Fuk-Woo Chan et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹

Article Virology

The SARS-CoV-2 Exerts a Distinctive Strategy for Interacting with the ACE2 Human Receptor

Esther S. Brielle et al.

VIRUSES-BASEL (2020)

添加到收藏夹

Review Medicine, General & Internal

Middle East respiratory syndrome

Ziad A. Memish et al.

LANCET (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Jun Lan et al.

NATURE (2020)

添加到收藏夹

Article Cell Biology

The ACE2 expression in Sertoli cells and germ cells may cause male reproductive disorder after SARS-CoV-2 infection

Qiaoyan Shen et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

Joana Damas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Hot spot profiles of SARS-CoV-2 and human ACE2 receptor protein protein interaction obtained by density functional tight binding fragment molecular orbital method

Hocheol Lim et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Type 1 Diabetes: an Association Between Autoimmunity, the Dynamics of Gut Amyloid-producing E. coli and Their Phages

George Tetz et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Prion-like Domains in Eukaryotic Viruses

George Tetz et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Microbiology

Prion-Like Domains in Phagobiota

George Tetz et al.

FRONTIERS IN MICROBIOLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond

Guangwen Lu et al.

TRENDS IN MICROBIOLOGY (2015)

添加到收藏夹

Article Biochemical Research Methods

PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition

Alex K. Lancaster et al.

BIOINFORMATICS (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Functional amyloid - from bacteria to humans

Douglas M. Fowler et al.

TRENDS IN BIOCHEMICAL SCIENCES (2007)

添加到收藏夹

Review Neurosciences

Unfolding the role of protein misfolding in neurodegenerative diseases

C Soto

NATURE REVIEWS NEUROSCIENCE (2003)

添加到收藏夹

Article Multidisciplinary Sciences

A census of glutamine/asparagine-rich regions: Implications for their conserved function and the prediction of novel prions

MD Michelitsch et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.