期刊
MICROORGANISMS
卷 9, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms9122578
关键词
immune response; antiviral; SARS-CoV-2; lymphocytes; antibodies; inflammation
类别
This review focuses on the immune response to SARS-CoV-2 infection, highlighting the two compartments of antiviral immunity - humoral and cellular immunity, and discussing the immunopathology of SARS-CoV-2 as well as related diagnostic and therapeutic approaches.
After two previous episodes, in 2002 and 2012, when two highly pathogenic coronaviruses (SARS, MERS) with a zoonotic origin emerged in humans and caused fatal respiratory illness, we are today experiencing the COVID-19 pandemic produced by SARS-CoV-2. The main question of the year 2021 is if naturally- or artificially-acquired active immunity will be effective against the evolving SARS-CoV-2 variants. This review starts with the presentation of the two compartments of antiviral immunity-humoral and cellular, innate and adaptive-underlining how the involved cellular and molecular actors are intrinsically connected in the development of the immune response in SARS-CoV-2 infection. Then, the SARS-CoV-2 immunopathology, as well as the derived diagnosis and therapeutic approaches, will be discussed.
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