Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease-A Retrospective, Case-Control Pilot Study

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SEMINARS IN CANCER BIOLOGY (2022)

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A UPLC-MS/MS method for the determination of oxidative stress biomarkers in amniotic fluid

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Corpus callosum size by neurosonography in fetuses with congenital heart defect and relationship with expected pattern of brain oxygen supply

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Summary: The study aimed to evaluate corpus callosum size in fetuses with isolated major congenital heart defects using neurosonography. Findings revealed that fetuses with major CHD had a smaller corpus callosum compared to controls, particularly in the subgroup with expected poorer brain oxygen supply. This suggests sonographic corpus callosum size could serve as a clinically feasible marker of abnormal white matter development in congenital heart defects.

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Summary: This study examined the relationship between delayed brain development in fetuses with certain heart conditions and their susceptibility to postnatal white matter injury. Lower total brain volume in late gestation was associated with increased risk of white matter injury in fetuses with d-transposition of the great arteries, but not in those with hypoplastic left heart syndrome. Rate of brain growth was not found to be a risk factor for white matter injury in either group, indicating different implications for postnatal risk of white matter injury.

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ULTRASOUND IN OBSTETRICS & GYNECOLOGY (2016)

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Mid-gestation brain Doppler and head biometry in fetuses with congenital heart disease predict abnormal brain development at birth

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Evidence of second-trimester changes in head biometry and brain perfusion in fetuses with congenital heart disease

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Mortality Resulting From Congenital Heart Disease Among Children and Adults in the United States, 1999 to 2006

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Effects of congenital heart disease on brain development

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Abnormal brain development in newborns with congenital heart disease

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NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Proteomics analysis of human amniotic fluid

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Autoregulation of cerebral blood flow in fetuses with congenital heart disease: The brain sparing effect

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PEDIATRIC CARDIOLOGY (2003)

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2002)

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Preoperative risk-of-death prediction model in heart surgery with deep hypothermic circulatory arrest in the neonate

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Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease-A Retrospective, Case-Control Pilot Study

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