期刊
ANTIOXIDANTS
卷 11, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/antiox11020407
关键词
benzothiazole; multifunctional; UV filter; antioxidant; antimicrobial; cosmeceutical
资金
- University of Ferrara
- Ambrosialab srl (Ferrara, Italy)
- Italian Ministero dellIstruzione, Universita e della Ricerca [2010E84AA4_002]
This study developed a series of isosteric benzothiazoles and investigated their multifunctional effects in skin disease treatment. Two compounds (9a and 10a) showed excellent antioxidant, photoprotective, and antifungal activity, as well as growth inhibition of melanoma tumor cells, making them promising candidates for skin protective and preventive agents.
Skin diseases often give multifactorial damages; therefore, the development of multifunctional compounds represents a suitable approach especially against disorders that are induced by oxidative stress. Thus, taking into account the successful results we achieved on benzimidazoles, we have devised a new series of isosteric benzothiazoles and investigated their antioxidant, photoprotective, antifungal and antiproliferative activity. Particular attention has been paid to synergistic antioxidant and photoprotective properties. For compounds 9a and 10a, a multifunctional profile was outlined, supported by an excellent filtering capacity, mainly UVB, which has higher capacities than those of the reference PBSA which is currently in the market as a UV sunscreen filter. The two compounds were also the best in terms of growth inhibition of dermatophytes and Candida albicans, and 10a also showed good antioxidant activity. Furthermore, 9a was also effective on melanoma tumor cells (SK-Mel 5), making these compounds good candidates in the development of new skin protective and preventive agents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据