A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene?

Letter Gastroenterology & Hepatology

Global prediction of primary liver cancer incidences and mortality in 2040

Chenxi Li et al.

JOURNAL OF HEPATOLOGY (2023)

Article Immunology

Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine Recipients

Lu Lu et al.

Summary: Immune sera from BNT162b2 and Coronavac recipients showed reduced neutralizing antibody titers against the omicron variant. The presence of the spike R346K mutation did not affect the neutralization susceptibility.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Multidisciplinary Sciences

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Yunlong Cao et al.

Summary: The Omicron variant of SARS-CoV-2 contains 15 mutations in the receptor-binding domain, leading to evasion of over 85% of tested neutralizing antibodies. Different epitope groups of neutralizing antibodies are affected to varying degrees by single mutations of Omicron. Antibodies targeting the conserved region of sarbecovirus remain most effective against Omicron.

NATURE (2022)

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Article Biochemistry & Molecular Biology

The spike protein of SARS-CoV-2 induces heme oxygenase-1: Pathophysiologic implications

Raman Deep Singh et al.

Summary: This study demonstrates that the expression of the spike protein of SARS-CoV-2 in kidney cells can simulate maladaptive and adaptive responses relevant to acute kidney injury (AKI) in COVID-19. Spike protein expression upregulates potentially nephrotoxic genes, as well as the cytoprotective gene HO-1 and relevant signaling pathways. Quercetin, an HO-1 inducer, shows potential as a clinically feasible protective strategy in AKI associated with COVID-19.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2022)

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Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

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Review Pharmacology & Pharmacy

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Yu-Qiong He et al.

Summary: ALI and ARDS are common life-threatening lung diseases with high mortality rates, but there is still a lack of effective pharmacological therapies. Developing new drugs for therapy of ALI/ARDS is in great demand, as natural compounds have shown potential therapeutic effects and may also be helpful for treatment of COVID-19.

PHARMACOLOGICAL RESEARCH (2021)

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Article Immunology

Neuroinvasion of SARS-CoV-2 in human and mouse brain

Eric Song et al.

Summary: The study showed through three approaches that SARS-CoV-2 is capable of infecting brain neurons, leading to metabolic changes and pathological features without triggering type I interferon responses. These results provide evidence for the neuroinvasive capacity of SARS-CoV-2 and the unexpected consequence of direct infection of neurons by the virus.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Medicine, General & Internal

SARS-CoV-2 Transmission From People Without COVID-19 Symptoms

Michael A. Johansson et al.

Summary: The study suggests that more than half of COVID-19 transmission may come from asymptomatic individuals, highlighting the importance of measures beyond identifying and isolating symptomatic cases in controlling the spread of the virus.

JAMA NETWORK OPEN (2021)

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Article Critical Care Medicine

Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial

Jordan J. Feld et al.

Summary: The study investigated the safety and efficacy of peginterferon lambda in treating outpatients with mild-to-moderate COVID-19. Results showed that patients treated with peginterferon lambda had a faster decline in viral RNA and were more likely to clear the virus by day 7 compared to the placebo group.

LANCET RESPIRATORY MEDICINE (2021)

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Article Multidisciplinary Sciences

Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction

Dong-Hwi Kim et al.

Summary: HO-1 induced by hemin effectively suppresses SARS-CoV-2 replication, making it a potential therapeutic candidate for COVID-19.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

High-dimensional characterization of post-acute sequelae of COVID-19

Ziyad Al-Aly et al.

Summary: This study comprehensively describes the post-acute sequelae of COVID-19 using national healthcare databases, finding increased risk of death and use of health resources beyond the first 30 days of illness, as well as incident sequelae in various organ systems, increased use of therapeutic agents, and evidence of laboratory abnormalities. The findings show a risk gradient according to the severity of acute COVID-19 infection and highlight the burden of health loss experienced by patients who survive the acute phase.

NATURE (2021)

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Article Cell Biology

SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery

Apoorva Mulay et al.

Summary: This study established primary human lung epithelial infection models to investigate the initial responses of proximal and distal lung epithelium to SARS-CoV-2 infection. The findings showed that epithelial cells in different areas of the lungs are susceptible to SARS-CoV-2 infection, leading to a cell-autonomous proinflammatory response, with remdesivir proving effective in suppressing viral infection and replication.

CELL REPORTS (2021)

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Article Cell Biology

miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts

Yat-Yin Law et al.

Aging-US (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Proteins Bind to Hemoglobin and Its Metabolites

Guilherme C. Lechuga et al.

Summary: This study found that at least five proteins (S, N, M, Nsp3, and Nsp7) of SARS-CoV-2 recruit Hb/metabolites. The motifs of the RDB of SARS-CoV-2 spike that binds Hb and the sites of the heme bind-N protein were revealed. Additionally, these compounds and PpIX block virus adsorption and replication.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Microbiology

The Emerging Concern and Interest SARS-CoV-2 Variants

Edyta Janik et al.

Summary: Since the discovery of the SARS-CoV-2 responsible for COVID-19 in December 2019, the virus has continually mutated, with three variants of concern and four variants of interest being distinguished in recent months and requiring close monitoring.

PATHOGENS (2021)

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Review Biochemistry & Molecular Biology

The signal pathways and treatment of cytokine storm in COVID-19

Lan Yang et al.

Summary: The COVID-19 pandemic is a global crisis with devastating effects, where immunopathology plays a crucial role in disease progression, particularly the cytokine storm which has a significant impact on prognosis. Understanding and targeting the pathways involved in cytokine storm could lead to more effective treatment strategies for COVID-19.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Letter Critical Care Medicine

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

Qiurong Ruan et al.

INTENSIVE CARE MEDICINE (2020)

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Article Immunology

Curcumin ameliorates hepatic chronic inflammation induced by bile duct obstruction in mice through the activation of heme oxygenase-1

Dan Chen et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Virology

Emerging coronaviruses: Genome structure, replication, and pathogenesis

Yu Chen et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Article Medicine, General & Internal

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo et al.

CELL (2020)

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Review Microbiology

Type I and Type III Interferons - Induction, Signaling, Evasion, and Application to Combat COVID-19

Annsea Park et al.

CELL HOST & MICROBE (2020)

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Review Rheumatology

Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

Mehmet Soy et al.

CLINICAL RHEUMATOLOGY (2020)

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Article Biochemistry & Molecular Biology

MicroRNA-155 inhibits dengue virus replication by inducing heme oxygenase-1-mediated antiviral interferon responses

Yu-Chieh Su et al.

FASEB JOURNAL (2020)

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Article Critical Care Medicine

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

Zhe Xu et al.

LANCET RESPIRATORY MEDICINE (2020)

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Review Infectious Diseases

The SARS-CoV-2 outbreak: What we know

Di Wu et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Review Biochemistry & Molecular Biology

SARS-CoV-2 Inflammatory Syndrome. Clinical Features and Rationale for Immunological Treatment

Marcella Prete et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Allergy

Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19

Yang Yang et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Editorial Material Medicine, Research & Experimental

SARS-CoV-2: a storm is raging

Savannah F. Pedersen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Immunology

COVID-19 as an Acute Inflammatory Disease

Rose H. Manjili et al.

JOURNAL OF IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

Novel therapeutic targets for SARS-CoV-2-induced acute lung injury: targeting a potential IL-1β/Neutrophil Extracellular Traps feedback loop

Ahmed Yaqinuddin et al.

MEDICAL HYPOTHESES (2020)

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Article Immunology

Interferon-α2b Treatment for COVID-19

Qiong Zhou et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Human Heme Oxygenase-1 Induced by Interleukin-6 via JAK/STAT3 Pathways Is a Tumor Suppressor Gene in Hepatoma Cells

Kun-Chun Chiang et al.

ANTIOXIDANTS (2020)

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Article Pediatrics

Heme oxygenase-1 alleviates eosinophilic inflammation by inhibiting STAT3-SOCS3 signaling

Lin Xiaoliang et al.

PEDIATRIC PULMONOLOGY (2020)

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Article Microbiology

A Randomized Clinical Trial of the Efficacy and Safety of Interferon β-1a in Treatment of Severe COVID-19

Effat Davoudi-Monfared et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

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Review Pharmacology & Pharmacy

Targeting the Heme Oxygenase 1/Carbon Monoxide Pathway to Resolve Lung Hyper-Inflammation and Restore a Regulated Immune Response in Cystic Fibrosis

Caterina Di Pietro et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Immunology

Cytokine Storm in COVID-19-Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper

Sonu Bhaskar et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases

Samanta C. Funes et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Therapeutic effects of CO-releaser/Nrf2 activator hybrids (HYCOs) in the treatment of skin wound, psoriasis and multiple sclerosis

Zeina El Ali et al.

REDOX BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Myxovirus Resistance Protein 1 (MX1), a Novel HO-1 Interactor, Tilts the Balance of Endoplasmic Reticulum Stress towards Pro-Death Events in Prostate Cancer

Emiliano Ortiz et al.

BIOMOLECULES (2020)

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Article Multidisciplinary Sciences

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Carolina Lucas et al.

NATURE (2020)

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Review Biochemistry & Molecular Biology

Extrapulmonary manifestations of COVID-19

Aakriti Gupta et al.

NATURE MEDICINE (2020)

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Review Biochemistry & Molecular Biology

The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19)

Neelu Batra et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Chemistry, Multidisciplinary

Bilirubin nanomedicine alleviates psoriatic skin inflammation by reducing oxidative stress and suppressing pathogenic signaling

Hyeongseop Keum et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Cell Biology

COVID-19 and multiorgan failure: A narrative review on potential mechanisms

Tahmineh Mokhtari et al.

JOURNAL OF MOLECULAR HISTOLOGY (2020)

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Review Pharmacology & Pharmacy

Can Activation of NRF2 Be a Strategy COVID-19?

Antonio Cuadrado et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

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Article Multidisciplinary Sciences

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

David Olagnier et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Investigation of COVID-19 comorbidities reveals genes and pathways coincident with the SARS-CoV-2 viral disease

Mary E. Dolan et al.

SCIENTIFIC REPORTS (2020)

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Review Biochemistry & Molecular Biology

Therapeutic Potential of Heme Oxygenase-1 and Carbon Monoxide in Acute Organ Injury, Critical Illness, and Inflammatory Disorders

Stefan W. Ryter

ANTIOXIDANTS (2020)

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Review Medicine, Research & Experimental

Long-Term Respiratory and Neurological Sequelae of COVID-19

Fuzhou Wang et al.

MEDICAL SCIENCE MONITOR (2020)

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Article Immunology

Interferon β-1b in treatment of severe COVID-19: A randomized clinical trial

Hamid Rahmani et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Genetics & Heredity

Genomic characterization of a novel SARS-CoV-2

Rozhgar A. Khailany et al.

GENE REPORTS (2020)

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Review Medicine, General & Internal

A Review of Neurological Complications or COVID-19

Mack Sheraton et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2020)

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Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Immunology

CD8+ T cells in HIV control, cure and prevention

David R. Collins et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Gastroenterology & Hepatology

MicroRNA-let-7c suppresses hepatitis C virus replication by targeting Bach1 for induction of haem oxygenase-1 expression

Wei-Chun Chen et al.

JOURNAL OF VIRAL HEPATITIS (2019)

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Review Medicine, General & Internal

Ebola virus disease

Denis Malvy et al.

LANCET (2019)

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Article Virology

heme oxygenase-1 agonist CoPP suppresses influenza virus replication through IRF3-mediated generation of IFN-α/β

Lin-Lin Ma et al.

VIROLOGY (2019)

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Article Virology

DMO-CAP inhibits influenza virus replication by activating heme oxygenase-1-mediated IFN response

Ming Zhong et al.

VIROLOGY JOURNAL (2019)

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Review Pharmacology & Pharmacy

Heme Catabolic Pathway in Inflammation and Immune Disorders

Bing Wu et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Review Biochemistry & Molecular Biology

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

Toshitaka Nakamura et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2019)

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Article Multidisciplinary Sciences

Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines

Ryoko Takei et al.

PLOS ONE (2019)

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Article Biochemistry & Molecular Biology

Neuroprotection after Hemorrhagic Stroke Depends on Cerebral Heme Oxygenase-1

Sandra Kaiser et al.

ANTIOXIDANTS (2019)

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Article Virology

Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus

Chaker El Kalamouni et al.

VIRUSES-BASEL (2019)

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Article Rheumatology

Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis

Zhuming Chen et al.

ARTHRITIS RESEARCH & THERAPY (2019)

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Review Biotechnology & Applied Microbiology

Drug repurposing: progress, challenges and recommendations

Sudeep Pushpakom et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Biochemistry & Molecular Biology

Bax Inhibitor-1 Acts as an Anti-Influenza Factor by Inhibiting ROS Mediated Cell Death and Augmenting Heme-Oxygenase 1 Expression in Influenza Virus Infected Cells

Mohammed Kawser Hossain et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Nutrition & Dietetics

Heme oxygenase-1 prevents murine intestinal inflammation

Tomohisa Takagi et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2018)

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Article Medicine, General & Internal

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

A. Danielle Iuliano et al.

LANCET (2018)

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Article Cell Biology

Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury

Xiaozhen Chen et al.

MEDIATORS OF INFLAMMATION (2018)

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Review Cell Biology

The Role of Macrophages in the Pathogenesis of ALI/ARDS

Xiaofang Huang et al.

MEDIATORS OF INFLAMMATION (2018)

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Review Endocrinology & Metabolism

Redox Functions of Heme Oxygenase-1 and Biliverdin Reductase in Diabetes

Luc Rochette et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

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Article Medicine, Research & Experimental

Upregulation of heme oxygenase-1 protected against brain damage induced by transient cerebral ischemia-reperfusion injury in rats

Xiufang Lu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2018)

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Review Immunology

Could Heme Oxygenase-1 Be a New Target for Therapeutic Intervention in Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome?

Marcelo L. M. Pereira et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory NLRP3-RXR axis in asthma

Jiajia Lv et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Article Oncology

HO-1 is a favorable prognostic factor for HBV-HCC patients who underwent hepatectomy

Chun-Nan Yeh et al.

CANCER MANAGEMENT AND RESEARCH (2018)

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Article Respiratory System

Regulatory role of heme oxygenase-1 in silica-induced lung injury

Kentaro Nakashima et al.

RESPIRATORY RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid

Sookjin Kang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

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Article Neurosciences

Degradation of heme oxygenase-1 by the immunoproteasome in astrocytes: A potential interferon-γ-dependent mechanism contributing to HIV neuropathogenesis

Colleen E. Kovacsics et al.

GLIA (2017)

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Article Infectious Diseases

Hemin ameliorates influenza pneumonia by attenuating lung injury and regulating the immune response

Conghui Wang et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2017)

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Article Immunology

Heme Oxygenase-1 Modulates Human Respiratory Syncytial Virus Replication and Lung Pathogenesis during Infection

Janyra A. Espinoza et al.

JOURNAL OF IMMUNOLOGY (2017)

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Review Immunology

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

Rudragouda Channappanavar et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

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Article Medicine, Research & Experimental

A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice

Hui-Min Li et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)

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Article

Inflammatory responses and inflammation-associated diseases in organs

Linlin Chen et al.

Oncotarget (2017)

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Article Microbiology

Pharmacological Induction of Heme Oxygenase-1 Impairs Nuclear Accumulation of Herpes Simplex Virus Capsids upon Infection

Francisco J. Ibanez et al.

FRONTIERS IN MICROBIOLOGY (2017)

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Article Neurosciences

Heme Oxygenase-1 Induction by Carbon Monoxide Releasing Molecule-3 Suppresses Interleukin-1β-Mediated Neuroinflammation

Chih-Chung Lin et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

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Article Medicine, General & Internal

Biliverdin Protects the Isolated Rat Lungs from Ischemia-reperfusion Injury via Antioxidative, Anti-inflammatory and Anti-apoptotic Effects

Wen-Fang Tian et al.

CHINESE MEDICAL JOURNAL (2017)

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Review Pathology

Modulation of Antiviral Immunity by Heme Oxygenase-1

Janyra A. Espinoza et al.

AMERICAN JOURNAL OF PATHOLOGY (2017)

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Article Medical Laboratory Technology

Acute Lung Injury A Clinical and Molecular Review

Yasmeen Butt et al.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2016)

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Article Cardiac & Cardiovascular Systems

Protective role of heme oxygenase-1 in atrial remodeling

Yung-Hsin Yeh et al.

BASIC RESEARCH IN CARDIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Rupestonic acid derivative YZH-106 suppresses influenza virus replication by activation of heme oxygenase-1-mediated interferon response

Lin-Lin Ma et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

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Article Multidisciplinary Sciences

Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling

Bin Zhang et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

Human heme oxygenase 1 is a potential host cell factor against dengue virus replication

Chin-Kai Tseng et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

Effect of Heme Oxygenase-1 on Mitofusin-1 protein in LPS-induced ALI/ARDS in rats

Jianbo Yu et al.

SCIENTIFIC REPORTS (2016)

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Article Urology & Nephrology

Glomerular Epithelial Cells-Targeted Heme Oxygenase-1 Over Expression in the Rat: Attenuation of Proteinuria in Secondary But Not Primary Injury

Vassilios Atsaves et al.

NEPHRON (2016)

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Article Gastroenterology & Hepatology

Sirt1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet

Xiaojun Liu et al.

JOURNAL OF HEPATOLOGY (2015)

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Article Oncology

Dynamic correlation between induction of the expression of heme oxygenase-1 and hepatitis B viral replication

Yu-Ming Shen et al.

MOLECULAR MEDICINE REPORTS (2015)

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Article Multidisciplinary Sciences

Tissue-based map of the human proteome

Mathias Uhlen et al.

SCIENCE (2015)

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Article Clinical Neurology

Astrocyte Overexpression of Heme Oxygenase-1 Improves Outcome After Intracerebral Hemorrhage

Jing Chen-Roetling et al.

STROKE (2015)

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Review Immunology

Herpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease

Paula A. Suazo et al.

MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2015)

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Review Biochemistry & Molecular Biology

New Insights into Intracellular Locations and Functions of Heme Oxygenase-1

Louise L. Dunn et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

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Article Biochemistry & Molecular Biology

The effect of anti-inflammatory properties of ferritin light chain on lipopolysaccharide-induced inflammatory response in murine macrophages

Yumei Fan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

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Review Clinical Neurology

Carbon monoxide may be an important molecule in migraine and other headaches

Nanna Arngrim et al.

CEPHALALGIA (2014)

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Review Urology & Nephrology

Heme oxygenase-1 and acute kidney injury

Karl A. Nath

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2014)

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Article Immunology

5-Aminolevulinic acid combined with ferrous iron enhances the expression of heme oxygenase-1

Yoshiaki Nishio et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2014)

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Article Immunology

Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1

Yun-peng Luo et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2014)

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Article Medicine, Research & Experimental

Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders

Alexander J. Gill et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

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Article Neurosciences

Systemic hemin therapy attenuates blood-brain barrier disruption after intracerebral hemorrhage

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A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene?

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