期刊
ANTIOXIDANTS
卷 11, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/antiox11020276
关键词
heme oxygenase 1; COVID-19; influenza A virus; respiratory syncytial virus; human immunodeficiency virus; Ebola virus; Dengue virus; Zika virus; Hepatitis virus; SARS-CoV-2
资金
- [AGENCIA-PICT-2019-03215]
Heme oxygenase 1 (HO-1) plays a crucial role in maintaining cellular homeostasis and possesses cytoprotective, antioxidative, anti-inflammatory, and antiviral properties. This review highlights the protective role of HO-1 in inflammatory diseases and viral infections, suggesting its potential as a therapeutic target for ameliorating clinical manifestations during COVID-19.
Heme oxygenase 1 (HO-1), the rate-limiting enzyme in heme degradation, is involved in the maintenance of cellular homeostasis, exerting a cytoprotective role by its antioxidative and anti-inflammatory functions. HO-1 and its end products, biliverdin, carbon monoxide and free iron (Fe2+), confer cytoprotection against inflammatory and oxidative injury. Additionally, HO-1 exerts antiviral properties against a diverse range of viral infections by interfering with replication or activating the interferon (IFN) pathway. Severe cases of coronavirus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are characterized by systemic hyperinflammation, which, in some cases, leads to severe or fatal symptoms as a consequence of respiratory failure, lung and heart damage, kidney failure, and nervous system complications. This review summarizes the current research on the protective role of HO-1 in inflammatory diseases and against a wide range of viral infections, positioning HO-1 as an attractive target to ameliorate clinical manifestations during COVID-19.
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