A Cardioplegic Solution with an Understanding of a Cardiochannelopathy

Cardiac surgeries have been improved by accompanying developing cardioplegia solutions. However, the cardioplegia application presents an ongoing challenge with a view of a sufficiently restored cardiac function. In this review, we focus on the cardioplegia-induced mechanism and summarize the findings of studies undertaken to improve cardioprotective strategies. Currently, and somewhat surprisingly, relatively little is known about cardiac electrolyte regulation through channel physiology. We hope that an improved understanding of the electrolyte transport through ion channels/transporters and modulations of water channel aquaporins will provide an insight into cardiac channel physiology and a channel-based cardiac pathology of a cardiochannelopathy.

Automated summary

Cardiac surgeries have improved with the development of cardioplegia solutions, but challenges remain in restoring cardiac function fully. Current knowledge about cardiac electrolyte regulation through channel physiology is limited, and further research on ion channels/transporters and water channel aquaporin modulations is needed for insight into cardiac channel physiology and pathology.