期刊
ANTIOXIDANTS
卷 10, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/antiox10111758
关键词
epicardial adipose tissue; oxidative stress; inflammation; cardiovascular disease; exercise; physical activity
资金
- Biomedical Research and Innovation Platform of the South African Medical Research Council (SAMRC)
- National Research Foundation [117829]
Excessive epicardial adiposity is emerging as an important risk factor for cardiovascular diseases, and reducing epicardial fat thickness is crucial for attenuating CVD risk in the setting of metabolic disease. Physical exercise can reduce epicardial fat and decrease CVD risk in conditions of metabolic disease.
Excess epicardial adiposity, within a state of obesity and metabolic syndrome, is emerging as an important risk factor for the development of cardiovascular diseases (CVDs). Accordingly, increased epicardial fat thickness (EFT) implicates the exacerbation of pathological mechanisms involving oxidative stress and inflammation within the heart, which may accelerate the development of CVDs. This explains increased interest in targeting EFT reduction to attenuate the detrimental effects of oxidative stress and inflammation within the setting of metabolic syndrome. Here, we critically discuss clinical and preclinical evidence on the impact of physical exercise on EFT in correlation with reduced CVD risk within a setting of metabolic disease. This review also brings a unique perspective on the implications of oxidative stress and inflammation as major pathological consequences that link increased EFT to accelerated CVD risk in conditions of metabolic disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据