4.7 Review

Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer's Disease, Parkinson's Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Long COVID: cognitive complaints (brain fog) and dysfunction of the cingulate cortex

Jacques Hugon et al.

Summary: Long-lasting symptoms affecting multiple organs, including the brain, can disturb daily activities and delay complete recovery in COVID patients. Abnormal FDG PET findings in neurological long COVID cases may include hypometabolic regions of the cingulate cortex.

JOURNAL OF NEUROLOGY (2022)

Article Cell Biology

Inflammasome formation in the lungs of patients with fatal COVID-19

Stefano Toldo et al.

Summary: The study revealed intense expression of the inflammasome, particularly in leukocytes, within the lungs of all fatal COVID-19 patients. The number of ASC inflammasome specks per high power fields was significantly higher in the lungs of COVID-19 patients compared to controls. This suggests a potential molecular link between viral infection and cytokine release syndrome in fatal COVID-19 pneumonia.

INFLAMMATION RESEARCH (2021)

Review Cardiac & Cardiovascular Systems

COVID-19 Infection: Viral Macro- and Micro-Vascular Coagulopathy and Thromboembolism/Prophylactic and Therapeutic Management

Antonis S. Manolis et al.

Summary: COVID-19 predisposes patients to arterial and venous thrombosis, commonly leading to complications such as pulmonary embolism. Biomarkers related to coagulation and inflammation are considered useful diagnostic and prognostic tools for COVID-19-associated coagulopathy.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2021)

Review Gastroenterology & Hepatology

COVID-19: Discovery, diagnostics and drug development

Tarik Asselah et al.

Summary: COVID-19 started in Wuhan in 2019 and has become a global pandemic. The virus responsible, SARS-CoV-2, shares a high sequence identity with bat- and pangolin-derived coronaviruses. Risk factors for SARS-CoV-2 infection include age, obesity, diabetes, and hypertension.

JOURNAL OF HEPATOLOGY (2021)

Review Cell Biology

Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases

An-Guo Wu et al.

Summary: Neuroinflammation is considered detrimental in neurodegenerative diseases, with NLRP3 inflammasome playing a crucial role in exacerbating pathology and disease progression. Microglial autophagy is important in maintaining brain homeostasis and negatively regulating NLRP3 inflammasome-mediated neuroinflammation. Understanding sex differences in NLRP3 inflammasome-mediated neurodegenerative diseases will aid in developing targeted therapies and improving diagnostic and prognostic abilities.

AGEING RESEARCH REVIEWS (2021)

Review Pharmacology & Pharmacy

Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials

Motoaki Sano et al.

Summary: Hydrogen gas is a versatile therapeutic agent with benefits in reducing organ damage caused by ischemia-reperfusion, as well as anti-tumor, anti-inflammatory, and antioxidant effects. It is effective for a wide range of emergency conditions and organ preservation, making it an easily administered, inexpensive, and well-tolerated treatment option.

CURRENT PHARMACEUTICAL DESIGN (2021)

Article Biochemistry & Molecular Biology

activator PB125® as a carnosic acid-based therapeutic agent against respiratory viral diseases, including COVID-19

Joe M. McCord et al.

Summary: Nrf2 is a transcription factor that helps maintain metabolic balance by providing redox-sensitive gene expression, but its levels decline with aging, leading to pathological conditions. The use of phytochemicals can increase Nrf2 activation levels and help restore normal gene expression.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Immunology

T Cells: Warriors of SARS-CoV-2 Infection

Paola de Candia et al.

Summary: Severe infection with SARS-CoV-2 is characterized by massive cytokine release and T cell loss. The exaggerated host immune response, possibly dependent on T cell immunological memory, may significantly contribute to immunopathology and massive collateral damage in COVID-19 patients, especially in adults compared with children.

TRENDS IN IMMUNOLOGY (2021)

Review Nutrition & Dietetics

Nutraceutical Strategies for Suppressing NLRP3 Inflammasome Activation: Pertinence to the Management of COVID-19 and Beyond

Mark F. McCarty et al.

Summary: Inflammasomes are intracellular protein complexes that play a crucial role in the inflammatory response, with the NLRP3 inflammasome being the most studied. Research suggests that certain nutraceuticals may have the potential to suppress inflammasome activity, which could be beneficial for prevention and control of various medical disorders.

NUTRIENTS (2021)

Article Critical Care Medicine

Pilot trial of high-dose vitamin C in critically ill COVID-19 patients

Jing Zhang et al.

Summary: In this trial, high-dose vitamin C infusion did not improve IMVFD28 for patients with severe COVID-19, but may have a potential benefit in oxygenation.

ANNALS OF INTENSIVE CARE (2021)

Review Pharmacology & Pharmacy

Neurodegenerative Disease and the NLRP3 Inflammasome

Jonathan A. Holbrook et al.

Summary: The prevalence of neurodegenerative diseases is increasing, characterized by progressive neuronal loss, protein aggregation, metabolic abnormalities, and immune dysregulation. Research has shown that low-grade systemic inflammation may impact the development and progression of these diseases, and inflammation may also be a causative factor.

FRONTIERS IN PHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the rescue

Theoharis C. Theoharides et al.

Summary: COVID-19 not only causes severe respiratory problems but also leads to long-COVID syndrome, with symptoms including cognitive dysfunction and fatigue, particularly brain fog. The pathogenesis of brain fog in these illnesses is currently unknown, but may involve neuroinflammation caused by mast cells, which could be mitigated by the phytosomal formulation of the natural flavonoid luteolin.

BIOFACTORS (2021)

Review Biochemistry & Molecular Biology

Targeting Multiple Signal Transduction Pathways of SARS-CoV-2: Approaches to COVID-19 Therapeutic Candidates

Sajad Fakhri et al.

Summary: The complex pathogenic pathways of COVID-19 require urgent development of new therapies to address future epidemics. Research shows that the destructive pathways of COVID-19 share similar clinical symptoms with severe acute coronary syndrome. Revealing the exact pathogenic pathways and host factors can pave the way for combating COVID-19.

MOLECULES (2021)

Article Multidisciplinary Sciences

Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

Dorit Trudler et al.

Summary: Parkinson's disease is associated with the accumulation of alpha-synuclein and activation of microglia, potentially leading to neuronal death. This study shows that alpha-synuclein can activate NLRP3 inflammasome in human microglia and that alpha-synuclein-antibody complexes can exacerbate inflammation in a human context.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Immunology

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

Hongxu Xian et al.

Summary: The study found that metformin can attenuate COVID-19-induced ARDS by inhibiting NLRP3 inflammasome activation, IL-1 beta and IL-6 secretion, and by blocking ATP and mtDNA synthesis.

IMMUNITY (2021)

Article Cell Biology

Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway

Mingying Han et al.

Summary: The study demonstrated that verapamil alleviated LPS/GalN-induced ALF by suppressing the activation of the NLRP3 inflammasome, reducing inflammatory responses and oxidative stress.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Review Neurosciences

Microglial Implications in SARS-CoV-2 Infection and COVID-19: Lessons From Viral RNA Neurotropism and Possible Relevance to Parkinson's Disease

Ifeoluwa O. Awogbindin et al.

Summary: Since December 2019, humanity has been facing the devastating SARS-CoV-2 outbreak, resulting in over 3.1 million deaths globally. SARS-CoV-2 infection may lead to neurological symptoms and potentially cause chronic or permanent changes to neural tissues.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

Kun Wang et al.

Article Biochemistry & Molecular Biology

Beyond repression of Nrf2: An update on Keap1

Aleksandra Kopacz et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Review Biochemistry & Molecular Biology

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Liam Baird et al.

MOLECULAR AND CELLULAR BIOLOGY (2020)

Review Immunology

Targeting the NLRP3 Inflammasome in Severe COVID-19

Tracey L. Freeman et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Nrf2 Activator PB125(R)as a Potential Therapeutic Agent against COVID-19

Joe M. McCord et al.

ANTIOXIDANTS (2020)

Review Cell Biology

Coronavirus interactions with the cellular autophagy machinery

Katelyn Miller et al.

AUTOPHAGY (2020)

Article Pharmacology & Pharmacy

Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?

Antoni Sureda et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Review Medical Laboratory Technology

Ferritin in the coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis

Linlin Cheng et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2020)

Article Neurosciences

Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia

Yang Liu et al.

NEUROSCIENCE LETTERS (2020)

Review Pharmacology & Pharmacy

Can Activation of NRF2 Be a Strategy COVID-19?

Antonio Cuadrado et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

Review Allergy

Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

Jean Bousquet et al.

CLINICAL AND TRANSLATIONAL ALLERGY (2020)

Review Immunology

NLRP3 Inflammasome: The Stormy Link Between Obesity and COVID-19

Alberto Lopez-Reyes et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

Eunju Lee et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Critical Care Medicine

Carnosic Acid Improves Outcome after Repetitive Mild Traumatic Brain Injury

Mark E. Maynard et al.

JOURNAL OF NEUROTRAUMA (2019)

Review Biochemistry & Molecular Biology

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

Nathan Kelley et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

NLRP3 inflammasome activation drives tau pathology

Christina Ising et al.

NATURE (2019)

Review Cell Biology

Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent

Jonatas Rafael de Oliveira et al.

JOURNAL OF BIOMEDICAL SCIENCE (2019)

Review Cell Biology

Microglia in Alzheimer's disease

David V. Hansen et al.

JOURNAL OF CELL BIOLOGY (2018)

Review Medicine, Research & Experimental

Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity

Joana M. Andrade et al.

FUTURE SCIENCE OA (2018)

Article Multidisciplinary Sciences

MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress

Saumya Nagar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Immunology

Mitochondria are the powerhouses of immunity

Evanna L. Mills et al.

NATURE IMMUNOLOGY (2017)

Review Neurosciences

The Dietary Components Carnosic Acid and Carnosol as Neuroprotective Agents: a Mechanistic View

Marcos Roberto de Oliveira

MOLECULAR NEUROBIOLOGY (2016)

Review Neurosciences

Microglia-Mediated Inflammation and Neurodegenerative Disease

Ling Xu et al.

MOLECULAR NEUROBIOLOGY (2016)

Review Chemistry, Medicinal

Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance

Je-Wook Yu et al.

ARCHIVES OF PHARMACAL RESEARCH (2016)

Review Integrative & Complementary Medicine

The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer's Disease

Solomon Habtemariam

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

Review Cell Biology

Caspase-1 as a multifunctional inflammatory mediator: noncytokine maturation roles

Qian Sun et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2016)

Article Pharmacology & Pharmacy

Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice

Qi Guo et al.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2016)

Review Cell Biology

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

Letteria Minutoli et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Article Biochemistry & Molecular Biology

p62 links autophagy and Nrf2 signaling

Tao Jiang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Article Immunology

Mechanism of NLRP3 inflammasome activation

Fayyaz S. Sutterwala et al.

YEAR IN IMMUNOLOGY: MYELOID CELLS AND INFLAMMATION (2014)

Article Public, Environmental & Occupational Health

Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis

Sahar Y. Al-Okbi

TOXICOLOGY AND INDUSTRIAL HEALTH (2014)

Article Biochemistry & Molecular Biology

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

Naeha Subramanian et al.

Article Biochemistry & Molecular Biology

Rationally Designed Multi-Targeted Agents Against Neurodegenerative Diseases

W. J. Geldenhuys et al.

CURRENT MEDICINAL CHEMISTRY (2013)

Review Biochemistry & Molecular Biology

Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

Takumi Satoh et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Article Biochemistry & Molecular Biology

Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia

Mika Yanagitai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Article Agriculture, Multidisciplinary

Anti-Inflammatory Effects of Supercritical Carbon Dioxide Extract and Its Isolated Carnosic Acid from Rosmarinus officinalis Leaves

Chia-Feng Kuo et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2011)

Article Multidisciplinary Sciences

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou et al.

NATURE (2011)

Review Obstetrics & Gynecology

Management of moderate to severe Alzheimer's disease: Focus on memantine

Evangelyn Dominguez et al.

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY (2011)

Article Biochemistry & Molecular Biology

Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells

Kunio Kosaka et al.

JOURNAL OF BIOCHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation

Takumi Satoh et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Chemistry, Medicinal

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

Girish Rachakonda et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2008)

Review Neurosciences

Redox regulation of neuronal survival mediated by electrophilic compounds

Takumi Satoh et al.

TRENDS IN NEUROSCIENCES (2007)

Article Multidisciplinary Sciences

Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophillic phase II inducers

T Satoh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Agriculture, Multidisciplinary

Analysis of volatiles in porcine liver pates with added sage and rosemary essential oils by using SPME-GC-MS

M Estévez et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2004)

Review Biotechnology & Applied Microbiology

Anti-TNF-α therapies:: The next generation

MA Palladino et al.

NATURE REVIEWS DRUG DISCOVERY (2003)