期刊
ANTIOXIDANTS
卷 10, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/antiox10111793
关键词
FTO gene; dietary fiber; gene-diet interaction; glucose metabolism; macronutrients; obesity
资金
- Polish Ministry of Science and Higher Education [4774/B/P01/2009/37]
- Medical University of Bialystok
- European Union funds [POWR.03.02.00-00-I051/16]
- PO WER 2014-2020 [03/IMSD/G/2019]
This study aims to investigate the potential effects of FTO gene variants and dietary fiber intake on obesity-related parameters and lipid profile in a Polish population. The results suggest that different FTO genotypes respond differently to fiber intake, with high-fiber diets positively affecting anthropometric parameters but potentially worsening lipid profiles in certain genotype carriers.
Genetic and environmental factors play a key role in the development of obesity. The aim of this study was to explore the potential effect of fat mass and obesity-associated (FTO) rs3751812, rs8050136, rs9939609, rs6499640, rs8044769, and rs7190492 genotypes and dietary fiber intake on the obesity-related parameters and lipid profile in the Polish population. We selected 819 Polish Caucasian adult subjects (52.5% female and 47.5% male) for a final gene-diet interaction analysis, with mean BMI 28.5 (& PLUSMN;6.6) kg/m(2). We performed measurements of anthropometric parameters, total body fat content and distribution, and blood glucose, insulin, and lipid concentrations. Daily fiber intake was analyzed based on 3-day food-intake diaries, and daily physical activity was evaluated based on the International Physical Activity Questionnaire-Long Form. Our study shows that carriers of the GG genotype (rs3751812), CC genotype (rs8050136), and GG genotype (rs6499640) presented lower hip circumference if daily fiber intake was above 18 g per day. Additionally, GG genotype (rs3751812) and CC genotype (rs8050136) carriers showed surprisingly higher total cholesterol and LDL-cholesterol levels when they were stratified to the group with higher than median fiber intake. The results of this study highlight that high-fiber diets may positively affect anthropometric parameters but may also worsen lipid profile dependent on the FTO genotype.
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