期刊
ANTIOXIDANTS
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/antiox11010069
关键词
non-alcoholic fatty liver disease (NAFLD); steaotohepatitis (NASH); vitamin C; guinea pig model
资金
- LifePharm Centre for in vivo pharmacology [1001109652]
The study suggests that inadequate vitamin C intake may delay recovery in non-alcoholic fatty liver disease (NAFLD) and steatosis (NASH). A diet change combined with high vitamin C intake improves hepatic histopathological hallmarks, but vitamin C deficiency alone does not accelerate disease progression.
Oxidative stress is directly linked to non-alcoholic fatty liver disease (NAFLD) and the progression to steaotohepatitis (NASH). Thus, a beneficial role of antioxidants in delaying disease progression and/or accelerating recovery may be expected, as corroborated by recommendations of, e.g., vitamin E supplementation to patients. This study investigated the effect of vitamin C deficiency-often resulting from poor diets low in fruits and vegetables and high in fat-combined with/without a change to a low fat diet on NAFLD/NASH phenotype and hepatic transcriptome in the guinea pig NASH model. Vitamin C deficiency per se did not accelerate disease induction. However, the results showed an effect of the diet change on the resolution of hepatic histopathological hallmarks (steatosis, inflammation, and ballooning) (p < 0.05 or less) and indicated a positive effect of a high vitamin C intake when combined with a low fat diet. Our data show that a diet change is important in NASH regression and suggest that a poor vitamin C status delays the reversion towards a healthy hepatic transcriptome and phenotype. In conclusion, the findings support a beneficial role of adequate vitamin C intake in the regression of NASH and may indicate that vitamin C supplementation in addition to lifestyle modifications could accelerate recovery in NASH patients with poor vitamin C status.
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