期刊
ANTIOXIDANTS
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/antiox10101602
关键词
nonalcoholic steatohepatitis; lipidomics; oxidative stress; lipid hydroperoxides; triglycerides; ethanolamine phospholipids; plasmalogens; cardiolipins; fatty acyls; molecular species
资金
- Regional Innovation Strategy Support Program, Sapporo Health Innovation Smart-H, of the Ministry of Education, Culture, Sports, Science, and Technology, Japan
- Japan Society for the Promotion of Science (JSPS) KAKENHI Grant [19K16531, 21K14799]
- Grants-in-Aid for Scientific Research [21K14799, 19K16531] Funding Source: KAKEN
The study investigated the lipid composition in liver and kidney samples of NASH-model mice, revealing abnormal accumulation of triglycerides and depletion of phospholipids in the NASH group. The significant elevation of lipid hydroperoxide species in both liver and kidney of the NASH group indicates good diagnostic ability.
Nonalcoholic steatohepatitis (NASH) is a prevalent disease related to lipid metabolism disorder and oxidative stress. Lipid hydroperoxidation is known to be a critical driving force of various disorders and diseases. However, the combination of both intact and hydroperoxidized lipids in NASH has not yet been studied. In this work, the liver and kidney samples from NASH-model mice were comprehensively investigated by using the LC/MS-based lipidomic analysis. As a result, triglycerides showed the amount accumulation and the profile alteration for the intact lipids in the NASH group, while phosphatidylethanolamines, lysophosphatidylethanolamines, plasmalogens, and cardiolipins largely depleted, suggesting biomembrane damage and mitochondria dysfunction. Notably, the lipid hydroperoxide species of triglyceride and phosphatidylcholine exhibited a significant elevation in both the liver and the kidney of the NASH group and showed considerable diagnostic ability. Furthermore, the relationship was revealed between the lipid metabolism disturbance and the lipid hydroperoxide accumulation, which played a key role in the vicious circle of NASH. The present study suggested that the omics approach to the lipid hydroperoxide profile might be the potential diagnostic marker of NASH and other oxidative stress-related diseases, as well as the evaluative treatment index of antioxidants.
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