Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents

Article Dentistry, Oral Surgery & Medicine

Five-year survival and prognostic factors for oropharyngeal squamous cell carcinoma: retrospective cohort of a cancer center

Gloria Maria de Franca et al.

Summary: Oropharyngeal squamous cell carcinoma has a low 5-year overall survival rate. Poor prognostic factors include tumor stage III/IV, HPV p16-negative status, and an interval longer than 4 weeks between diagnosis and treatment initiation.

ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG (2022)

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Review Biochemistry & Molecular Biology

Insights into the structure and drug design of benzimidazole derivatives targeting the epidermal growth factor receptor (EGFR)

Mar'iyah Najihah Abdullah et al.

Summary: The review focuses on recent research reports on the anticancer activity of benzimidazole derivatives targeting EGFR expression cell lines, emphasizing on structure-activity relationship studies. The study indicates the significant potential of benzimidazole as tyrosine kinase inhibitors, but further challenges need to be addressed.

CHEMICAL BIOLOGY & DRUG DESIGN (2022)

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Article Neurosciences

Markers of Neuroinflammation in the Serum of Prepubertal Children with Fetal Alcohol Spectrum Disorders

Marco Fiore et al.

Summary: This study found an imbalance in peripheral neuroimmune pathways in FASD children, which could serve as early biomarkers for the deficits observed in FASD.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2022)

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Article Biochemistry & Molecular Biology

Urinary Ethyl Glucuronide for the Assessment of Alcohol Consumption During Pregnancy: Comparison between Biochemical Data and Screening Questionnaires

Flavio Maria Ceci et al.

Summary: This study compares the results of urinary EtG assays with questionnaires and food diaries to assess maternal alcohol consumption during pregnancy. The findings suggest that indirect estimation through questionnaires and food diaries may produce misleading results.

CURRENT MEDICINAL CHEMISTRY (2022)

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Review Neurosciences

Transgenerational Abnormalities Induced by Paternal Preconceptual Alcohol Drinking: Findings from Humans and Animal Models

Sergio Terracina et al.

Summary: Alcohol consumption during pregnancy and lactation can cause neurodevelopmental impairment in newborns, and paternal preconceptual alcohol consumption (PPAC) before copulating also has negative effects. It is suggested that couples planning pregnancies should completely avoid alcohol consumption.

CURRENT NEUROPHARMACOLOGY (2022)

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Review Gastroenterology & Hepatology

Does immune checkpoint inhibitor exhibit limited efficacy against non-viral hepatocellular carcinoma?: A review of clinical trials

Yuji Eso et al.

Summary: Immune checkpoint inhibitors have shown benefits in cancer treatment across different organs, but may have limited efficacy in NASH-related HCC patients. Combining anti-VEGF agents could potentially enhance the therapeutic effect of immune checkpoint inhibitors for NASH-related HCC.

HEPATOLOGY RESEARCH (2022)

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Review Obstetrics & Gynecology

Cancer screenings among sexual and gender minorities by midwives' point of view

Marisa P. Messina et al.

Summary: Women belonging to sexual and gender minorities face difficulties in participating in cancer screening programs due to fear of discrimination and lack of medical programs specific to LGBTQ community. There is a need for more research and tools to engage and assess cancer risks in this population.

MINERVA OBSTETRICS AND GYNECOLOGY (2022)

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Review Neurosciences

Nerve Growth Factor in Alcohol Use Disorders

Flavio Maria Ceci et al.

Summary: The nerve growth factor (NGF) is a member of the neurotrophic factor family, involved in the survival, differentiation, proliferation of neurons, as well as the regulation of immune and endocrine systems. Alcohol Use Disorders (AUD) caused by heavy drinking have negative effects on brain development and cognitive functions, and can lead to fetal alcohol spectrum disorders (FASD) when consumed during pregnancy.

CURRENT NEUROPHARMACOLOGY (2021)

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Review Neurosciences

A Healthy Gut for a Healthy Brain: Preclinical, Clinical and Regulatory Aspects

Carla Petrella et al.

Summary: There is a complex pathway of communications between the gut and the brain, where the microbiota can influence brain homeostasis and plasticity. Normalizing gut flora can prevent changes in behavior, suggesting the gut-brain axis as a possible target for pharmacological and dietary strategies.

CURRENT NEUROPHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Nerve Growth Factor, Stress and Diseases

Flavio Maria Ceci et al.

Summary: Stress is a constant threat to homeostasis, and various stimuli activate the adaptive stress system to restore balance. Nerve Growth Factor (NGF) plays a crucial role in mediating stress responses, with levels varying significantly after exposure to stressful events. Mental and metabolic disorders are often linked to stress, with NGF activity being a focus of recent research in this area.

CURRENT MEDICINAL CHEMISTRY (2021)

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Article Public, Environmental & Occupational Health

Limitations in American adults' awareness of and beliefs about alcohol as a risk factor for cancer

Marc T. Kiviniemi et al.

Summary: The study found that beliefs about whether drinking too much alcohol increases cancer risk are lacking among US adults, and misbeliefs and lack of knowledge about alcohol and health outcomes are more pronounced for cancer. Age, education, seeking health information, risk perceptions, and pessimistic beliefs about cancer predict problematic beliefs about alcohol's role as a risk factor for cancer.

PREVENTIVE MEDICINE REPORTS (2021)

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Article Biochemistry & Molecular Biology

Epidermal growth factor receptor inhibitors as potential anticancer agents: An update of recent progress

Bharti Sharma et al.

Summary: Epidermal growth factor receptor (EGFR) plays a vital role in cell signaling pathways, but clinically exploited inhibitors are not specific, leading to adverse effects. The main obstacles in developing new EGFR inhibitors are drug resistance, mutation, and selectivity. The aim is to generate novel drug candidates with greater selectivity and efficacy.

BIOORGANIC CHEMISTRY (2021)

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Review Pharmacology & Pharmacy

Targeting the Angiopoietin/Tie Pathway: Prospects for Treatment of Retinal and Respiratory Disorders

Racheal Grace Akwii et al.

Summary: The Ang/Tie pathway plays a crucial role in vascular physiology and has become a promising target for treating retinal and pulmonary vascular disorders. Modulation of Tie2 activation has shown promising outcomes in preclinical models, indicating potential for clinical application.

DRUGS (2021)

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Review Biochemistry & Molecular Biology

Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy

Gabriella D. Hartman et al.

Summary: As global population ages, the prevalence of neovascular eye diseases is increasing, highlighting the importance of developing therapies targeting multiple pathways to alleviate the burden and risks associated with current treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Drug resistance of targeted therapy for advanced non-small cell lung cancer harbored EGFR mutation: from mechanism analysis to clinical strategy

Yuxin Zhao et al.

Summary: The mechanisms of EGFR-TKIs resistance in NSCLC include EGFR mutations, upregulation of HER2, HGF/c-MET, VEGF, IGF1, EMT and STAT3 pathways, mutations of PTEN, RAS and BRAF genes, and activation of other bypass pathways. These interconnected mechanisms can be potential targets for the treatment of NSCLC.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

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Article Health Care Sciences & Services

Preoperative Prognostic Nutritional Index Value is Related to Postoperative Delirium in Elderly Patients After Noncardiac Surgery: A Retrospective Cohort Study

He Liu et al.

Summary: The preoperative PNI value is related to postoperative delirium in elderly patients after noncardiac surgery, with moderate to severe and serious malnutrition patients having a higher risk of developing POD. A cut-off value of PNI at 46.05 can be used to predict the occurrence of delirium.

RISK MANAGEMENT AND HEALTHCARE POLICY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Otorhinolaryngology

Diagnostic use of fine-needle aspiration cytology and core-needle biopsy in head and neck sarcomas

Sean C. Sheppard et al.

Summary: Fine-needle aspiration cytology (FNAC) and core-needle biopsy (CNB) play a useful role in diagnosing head and neck sarcomas, with CNB showing slightly higher accuracy. The diagnostic performance is more reliable for determining malignancy in vascular sarcomas, while chondrogenic sarcomas have poorer diagnostic accuracy.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2021)

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Article Psychology, Developmental

Feasibility of Ethyl Glucuronide Nail Testing Biomarker for Alcohol Use Among Youth Living With HIV

Henna Budhwani et al.

Summary: This study assessed the feasibility of using the ethyl glucuronide biomarker from nail sampling to measure alcohol use among youth living with HIV in the United States, and found correlations between the EtG biomarker and self-reported measures of alcohol use.

JOURNAL OF ADOLESCENT HEALTH (2021)

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Article Oncology

Prognostic impact and potential predictive role of baseline circulating tumor cells in locally advanced head and neck squamous cell carcinoma

Thiago Bueno de Oliveira et al.

Summary: The study identified the prognostic impact of CTCs and CTM, suggesting their potential role as predictors of ICT benefit in LA-HNSCC.

ORAL ONCOLOGY (2021)

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Article Oncology

Value of Panendoscopy in the Identification of Synchronous Malignancies in Patients Suffering from Oral Squamous Cell Carcinoma Without Clinical Signs of a Second Primary Tumor

Steffen Koerdt et al.

Summary: This study assessed the value of panendoscopy in identifying synchronous tumors in oral squamous cell carcinoma patients, with only a small percentage of patients diagnosed with secondary tumors. The necessity of routine panendoscopy in these patients needs to be critically re-evaluated.

ANTICANCER RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Mediterranean Diet, Brain and Nuscle: Olive Polyphenols and Resveratrol Protection in Neurodegenerative and Neuromuscular Disorders

Carla Petrella et al.

Summary: The Mediterranean diet, known for its intake of foods rich in antioxidants and polyphenols like olives and extra virgin olive oil, as well as resveratrol, shows beneficial properties for human health. These polyphenols could potentially be used in pharmaceutical formulations for disease treatment and have emerging importance in the prevention and management of neurodegenerative and neuromuscular disorders.

CURRENT MEDICINAL CHEMISTRY (2021)

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Review Clinical Neurology

Alcohol Drinking, Apolipoprotein Polymorphisms and the Risk of Cardiovascular Diseases

Flavio M. Ceci et al.

Summary: Moderate alcohol consumption is associated with lower risk of ACVD compared to abstaining, while heavy drinking increases the risk. Ethanol intoxication alters lipid profile, and genetic polymorphisms may influence the relationship between alcohol intake, HDL cholesterol levels, and atherosclerotic risk.

CURRENT NEUROVASCULAR RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Prognostic and Predictive Factors in Advanced Head and Neck Squamous Cell Carcinoma

Teresa Magnes et al.

Summary: Head and neck squamous cell carcinoma is a heterogeneous disease arising from the mucosa of the upper aerodigestive tract, with only about one third of patients responding to checkpoint inhibitors. HPV status and combined positive score are the main biomarkers used in clinical practice, while other factors like tumor mutational burden and immune microenvironment show promise but require validation in prospective trials.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Cardiac Toxicity Associated with Cancer Immunotherapy and Biological Drugs

Andrea Montisci et al.

Summary: Immunotherapy, including HER2-targeted therapies, immune checkpoint inhibitors and CAR-T therapy, utilizes the immune system to kill cancer cells. These drugs can cause cardiac toxicity, with varying degrees of impact on left ventricular function.

CANCERS (2021)

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Review Multidisciplinary Sciences

Prognostic value of FGFR1 expression and amplification in patients with HNSCC: A systematic review and meta-analysis

Yao Hu et al.

Summary: FGFR1 overexpression and amplification in head and neck squamous cell carcinoma (HNSCC) patients are associated with poor overall survival (OS), especially in those who are human papillomavirus (HPV) negative. Subgroup analysis based on molecular abnormalities showed similar results, indicating that FGFR1 may serve as a potential prognostic marker and therapeutic target in HNSCC.

PLOS ONE (2021)

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Review Nutrition & Dietetics

Association between Oral Cancer and Diet: An Update

Jesus Rodriguez-Molinero et al.

Summary: Oral cancer, the sixth most common malignant neoplasm in the world, is mainly caused by tobacco and alcohol, with diet also considered an important factor. Some dietary nutrients, such as fruits, vegetables, curcumin, and green tea, have anti-cancer effects, while a diet rich in red meat and fried foods may increase the risk. Research suggests that a diet rich in vegetables and fruits can have preventive effects against oral and other types of cancer.

NUTRIENTS (2021)

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Review Oncology

Further Understanding of the Immune Microenvironment in Head and Neck Squamous Cell Carcinoma: Implications for Prognosis

Nerina Denaro et al.

Summary: Through reviewing the literature, it was found that the tumor microenvironment plays a key role in tumor growth and treatment responses in head and neck cancer, with immune suppression and pro-tumoral environment being the main factors leading to immune resistance and rapid tumor growth. Additional investigations are needed to classify and treat patients with head and neck cancer effectively.

CANCER MANAGEMENT AND RESEARCH (2021)

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Review Microbiology

Meet the Insidious Players: Review of Viral Infections in Head and Neck Cancer Etiology with an Update on Clinical Trials

Lejla Mahmutovic et al.

Summary: Head and neck cancers are among the most common cancers, with complex etiology involving factors such as viral infections. Prognosis of patients is dependent on the site of the tumor, stage, and viral status. Current treatment options include radiotherapy, chemotherapy, targeted therapies, and immunotherapies.

MICROORGANISMS (2021)

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Article Oncology

Predicting Progression of Low-Grade Oral Dysplasia Using Brushing-Based DNA Ploidy and Chromatin Organization Analysis

Madhurima Datta et al.

Summary: Most oral cancers arise from oral potentially malignant lesions, which show varying grades of dysplasia. Risk prediction among oral low-grade dysplasia (LGD) can be challenging, and grading of dysplasia is subjective. This study uses DNA ploidy and chromatin organization (CO) scores to identify high-risk oral LGDs.

CANCER PREVENTION RESEARCH (2021)

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Review Otorhinolaryngology

Fact or fiction?: Oral cavity cancer in nonsmoking, nonalcohol drinking patients as a distinct entity-Scoping review

John Adeoye et al.

Summary: Oral cavity cancer is often linked with lifestyle factors like smoking and drinking, but there are also cases unrelated to these habits, with patients typically being elderly females with tumors on the tongue and gingivobuccal mucosa, diagnosed early with high levels of PD-L1 expression. Treatment response and prognosis are similar between these patients and those who smoke or drink.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2021)

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Article Otorhinolaryngology

Survival impact of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in head and neck cancer

William A. Stokes et al.

Summary: The study found that the usage of ARB is associated with improved overall survival and cancer-specific survival among head and neck cancer patients with chronic kidney disease or hypertension.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2021)

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Review Biochemistry & Molecular Biology

Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?

Constantin Stefani et al.

Summary: Colorectal cancer (CRC) is a prevalent malignancy globally, with incidence increasing each year. Factors such as unhealthy lifestyle, diet, diseases, environment, and genetic mutations are related to CRC development. Growth factors play a crucial role in the progression of CRC.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Patterns of alcohol use among early head and neck cancer survivors: A cross-sectional survey study using the alcohol use disorders identification test (AUDIT)

Sewit Teckie et al.

Summary: Alcohol consumption among survivors of head and neck cancer decreases shortly after treatment, but increases and stabilizes at a higher level by 24 months post-therapy. Concerningly, there is a significant increase in female users and moderate drinkers under 55 years old at this stage.

ORAL ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women

Akira Yokoyama et al.

Summary: The study evaluated the risk of alcohol dependence in Japanese men and women based on combinations of alcohol flushing, ALDH2, and ADH1B genotypes. Results showed that alcohol flushing, ALDH2 genotype, and ADH1B genotype were associated with alcohol dependence, and individuals with previous flushing tendencies experienced a disappearance of facial flushing after starting habitual drinking during young adulthood.

PLOS ONE (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

PET Imaging for Head and Neck Cancers

Charles Marcus et al.

RADIOLOGIC CLINICS OF NORTH AMERICA (2021)

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Review Oncology

Early-Phase Interventional Trials in Oral Cancer Prevention

Caroline McCarthy et al.

Summary: Oral cancer is a devastating disease with increasing incidence globally, and oral epithelial dysplasia is a potentially malignant disorder that increases the risk of developing oral cancer. Current management strategies fail to address the underlying pathogenesis of the disease, highlighting the urgent need for evidence-based medical treatments. Chemoprevention trials have not yet provided therapeutic agents for routine clinical practice, emphasizing the need for further clinical research to overcome this hurdle and explore novel strategies in oral cancer chemoprevention.

CANCERS (2021)

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Article Oncology

Nonsmoking and Nondrinking Oral Squamous Cell Carcinoma Patients: A Different Entity

Zhan Yang et al.

Summary: Nonsmoking and nondrinking (NSND) oral squamous cell carcinoma (SCC) patients have distinct demographic, pathologic characteristics, and prognosis compared to typical SCC patients. Smoking and drinking are independent factors affecting locoregional control and disease-specific survival.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Fluorescein-Guided Panendoscopy for Head and Neck Cancer Using Handheld Probe-Based Confocal Laser Endomicroscopy: A Pilot Study

Andreas Dittberner et al.

Summary: CLE shows potential for rapid and histological assessment in head and neck cancer surgery, making it a valuable complementary tool for in vivo intraoperative diagnosis during panendoscopy.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review

Caressa Hui et al.

Summary: Radiation therapy plays a crucial role in the treatment of head and neck cancer, helping to overcome treatment resistance and enhance the effectiveness of immunotherapy. This review discusses how radiation therapy affects the tumor microenvironment and its potential outcomes when combined with immunotherapy.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

The Role of Immunotherapy to Overcome Resistance in Viral-Associated Head and Neck Cancer

Rebecca R. Pharaon et al.

Summary: A subset of head and neck cancers in the oropharynx and nasopharynx associated with human papillomavirus or Epstein-Barr virus pose limited treatment options once patients develop recurrent or metastatic disease. Current studies are focusing on utilizing immunotherapy to overcome resistance to standard chemoradiation therapy and improve treatment response and outcomes in these viral-associated cancers.

FRONTIERS IN ONCOLOGY (2021)

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Review Immunology

A Contemporary Review of Immune Checkpoint Inhibitors in Advanced Clear Cell Renal Cell Carcinoma

Eun-mi Yu et al.

Summary: The use of checkpoint inhibitors in advanced and metastatic renal cell carcinomas has advanced rapidly in recent years. Combination therapies with immune checkpoint inhibitors and VEGF inhibitors have further improved outcomes. Promising therapies are expected to make more breakthroughs in the future.

VACCINES (2021)

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Review Biochemistry & Molecular Biology

NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology

Annelise Vermot et al.

Summary: NADPH oxidase (NOX) enzymes, which produce reactive oxygen species (ROS), play crucial roles in physiological processes such as immune defense, protein post-translational processing, cellular signaling, gene expression regulation, and cell differentiation. However, dysregulation of NOX can lead to various severe pathologies, making them potential therapeutic targets. Understanding the molecular mechanisms behind NOX regulation and ROS production is essential for investigating human diseases and developing new treatments.

ANTIOXIDANTS (2021)

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Review Oncology

Second-Line Treatment Options for Hepatocellular Carcinoma: Current Landscape and Future Direction

Surabhi Pathak et al.

Summary: Hepatocellular carcinoma is a leading cause of mortality worldwide, with the treatment landscape constantly evolving. The combination of atezolizumab plus bevacizumab has resulted in the longest overall survival yet known in hepatocellular carcinoma, changing the preferred treatment option. There are still great prospects for development in the treatment of hepatocellular carcinoma in the future.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2021)

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Review Biochemistry & Molecular Biology

The Role of Respiratory Microbiota in Lung Cancer

Dan Wang et al.

Summary: The pathogenesis and progression of lung cancer are associated with changes in the respiratory microbiota, which can impact tumor growth and metastasis through various mechanisms such as alterations in metabolism, immune response, inflammation, and angiogenesis. In addition, the microbiota plays a role in modifying the efficacy and toxicity of tumor immunotherapy and chemotherapy, making it a significant factor in cancer treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Pharmacology & Pharmacy

Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives

Ivan Guryanov et al.

Summary: VEGFs play crucial roles in angiogenesis, but dysregulation can lead to pathological angiogenesis in various diseases. Monoclonal antibodies and decoy receptors are commonly used to neutralize VEGFA in anti-angiogenic therapies. Short peptides are promising alternatives to full-length VEGFA inhibitors, overcoming some limitations of existing therapies.

PHARMACEUTICS (2021)

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Article Medicine, General & Internal

Efficacy of Gefitinib and Methorexate in Patients With Advanced Stage and Recurrent Head and Neck Cancer

Razia Irshad et al.

Summary: The study found that in patients with advanced-stage or recurrent head and neck cancer, gefitinib had marginally better results in terms of overall response and safety compared to methotrexate, particularly in recurrent cases.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Review Oncology

Head and neck cancer: the role of anti-EGFR agents in the era of immunotherapy

Morena Fasano et al.

Summary: Head and neck cancers are the seventh most common cancer worldwide, with squamous cell carcinomas being the most frequent histologic subtype. The current standard treatment includes surgery or radiotherapy for early stage diseases, while locally advanced cases may require a more aggressive multi-modal approach. Anti-EGFR targeted therapy cetuximab is currently the only approved targeted therapy option, with the recent development of immune-checkpoint inhibitors providing new treatment options.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2021)

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Review Otorhinolaryngology

Abscopal Effect Following Immunotherapy and Combined Stereotactic Body Radiation Therapy in Recurrent Metastatic Head and Neck Squamous Cell Carcinoma: A Report of Two Cases and Literature Review

Jonathan S. Choi et al.

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY (2020)

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Article Oncology

Cigarette Smoke Reduces the Efficacy of Cisplatin in Head and Neck Cancer Cells - Role of ABCG2

Florian Simon et al.

ANTICANCER RESEARCH (2020)

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Article Oncology

Diagnostic accuracy of brush biopsy-based cytology for the early detection of oral cancer and precursors in Fanconi anemia

Eunike Velleuer et al.

CANCER CYTOPATHOLOGY (2020)

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Review Biochemistry & Molecular Biology

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Manuela Leri et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Nutrition & Dietetics

Oxidative stress inhibition by resveratrol in alcohol-dependent mice

Carla Petrella et al.

NUTRITION (2020)

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Article Biochemistry & Molecular Biology

Fetus morphology changes by second-trimester ultrasound in pregnant women drinking alcohol

Giampiero Ferraguti et al.

ADDICTION BIOLOGY (2020)

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Review Oncology

Systemic Therapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma- A Systematic Review and Meta-Analysis

Ashley Lau et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

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Article Immunology

The Oral Microbiota May Have Influence on Oral Cancer

Ling Zhang et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Review Otorhinolaryngology

CDK4/6 inhibitors in P16/HPV16-negative squamous cell carcinoma of the head and neck

Camelia Billard-Sandu et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2020)

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Review Gastroenterology & Hepatology

Local Acetaldehyde: Its Key Role in Alcohol-Related Oropharyngeal Cancer

Mikko Salaspuro

VISCERAL MEDICINE (2020)

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Review Otorhinolaryngology

Prevalence of human papillomavirus in oral epithelial dysplasia: Systematic review and meta-analysis

Cecilie Dovey de la Cour et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2020)

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Review Oncology

Role of the oral microbiota in cancer evolution and progression

Jiwei Sun et al.

CANCER MEDICINE (2020)

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Article Oncology

Beyond conventional chemotherapy, targeted therapy and immunotherapy in squamous cell cancer of the oral cavity

Vijay M. Patil et al.

ORAL ONCOLOGY (2020)

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Review Oncology

Phase III study of nivolumab alone or combined with ipilimumab as immunotherapy versus standard of care in resectable head and neck squamous cell carcinoma

Henrike B. Zech et al.

FUTURE ONCOLOGY (2020)

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Article Public, Environmental & Occupational Health

Assessment of recent alcohol consumption by detecting ethyl glucuronide and ethyl sulphate level among traffic accident patients

Huseyin Dengiz et al.

TRAFFIC INJURY PREVENTION (2020)

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Article Food Science & Technology

Antioxidant properties of plant polyphenols in the counteraction of alcohol-abuse induced damage: Impact on the Mediterranean diet

Marco Fiore et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Review Oncology

The role of microenvironment in tumor angiogenesis

Xianjie Jiang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Multidisciplinary Sciences

VEGF knockdown enhances radiosensitivity of nasopharyngeal carcinoma by inhibiting autophagy through the activation of mTOR pathway

Li Chen et al.

SCIENTIFIC REPORTS (2020)

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Article Medicine, General & Internal

Head and neck squamous cell carcinoma

Daniel E. Johnson et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Review Oncology

Tumor Microenvironment and Immunotherapy Response in Head and Neck Cancer

Panagiota Economopoulou et al.

CANCERS (2020)

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Review Behavioral Sciences

Alcohol as an early life stressor: Epigenetics, metabolic, neuroendocrine and neurobehavioral implications

Stefania Ciafre et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2020)

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Review Biochemistry & Molecular Biology

Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression

Enli Yang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Neurosciences

NGF and BDNF Alterations by Prenatal Alcohol Exposure

Valentina Carito et al.

CURRENT NEUROPHARMACOLOGY (2019)

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Review Oncology

Potential role of cyclin-dependent kinase 4/6 inhibitors in the treatment of squamous cell carcinoma of the head and neck

Gabrielle van Caloen et al.

CURRENT OPINION IN ONCOLOGY (2019)

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Review Oncology

The microbiome and oral cancer: More questions than answers

Claire M. Healy et al.

ORAL ONCOLOGY (2019)

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Review Developmental Biology

Oxidative stress and DNA damage in the mechanism of fetal alcohol spectrum disorders

Shama Bhatia et al.

BIRTH DEFECTS RESEARCH (2019)

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Article Microbiology

ADH1 promotes Candida albicans pathogenicity by stimulating oxidative phosphorylation

Yanjun Song et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2019)

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Review Oncology

The role of DNA image cytometry in screening oral potentially malignant lesions using brushings: A systematic review

Madhurima Datta et al.

ORAL ONCOLOGY (2019)

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Review Clinical Neurology

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease

G. C. Roman et al.

REVUE NEUROLOGIQUE (2019)

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Review Environmental Sciences

Environmental risk factors for cancer - review paper

Anna Maria Lewandowska et al.

ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE (2019)

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Article Oncology

Identification and validation of novel microenvironment-based immune molecular subgroups of head and neck squamous cell carcinoma: implications for immunotherapy

Y. -P. Chen et al.

ANNALS OF ONCOLOGY (2019)

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Editorial Material Oncology

Virtual microdissection in the molecular subtyping of head and neck squamous carcinoma-a 'Virtual Reality' of the tumor microenvironment?

B. B. Y. Ma

ANNALS OF ONCOLOGY (2019)

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Review Biochemistry & Molecular Biology

How alcohol drinking affects our genes: an epigenetic point of view

Stefania Ciafre et al.

BIOCHEMISTRY AND CELL BIOLOGY (2019)

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Article Dentistry, Oral Surgery & Medicine

Is panendoscopy a necessary staging procedure in patients with lacking risk factors and oral squamous cell carcinoma?

Karl Metzger et al.

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY (2019)

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Article Psychology, Biological

Drop-out, relapse and abstinence in a cohort of alcoholic people under detoxification

Roberta Ledda et al.

PHYSIOLOGY & BEHAVIOR (2019)

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Review Biochemistry & Molecular Biology

Beyond EGFR inhibition: multilateral combat strategies to stop the progression of head and neck cancer

Hyung Kwon Byeon et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Review Medicine, General & Internal

Inflammation and Cancer

Nitin Singh et al.

ANNALS OF AFRICAN MEDICINE (2019)

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Review Medicine, Research & Experimental

Human oral microbiota and its modulation for oral health

Yangheng Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Pharmacology & Pharmacy

Virtual Morris task responses in individuals in an abstinence phase from alcohol

Mauro Ceccanti et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2018)

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Review Neurosciences

Impact of Dietary Fats on Brain Functions

Rosanna Chianese et al.

CURRENT NEUROPHARMACOLOGY (2018)

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Article Oncology

Comprehensive genomic profiling of head and neck squamous cell carcinoma reveals FGFR1 amplifications and tumour genomic alterations burden as prognostic biomarkers of survival

C. Dubot et al.

EUROPEAN JOURNAL OF CANCER (2018)

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Review Oncology

Optimizing treatments for recurrent or metastatic head and neck squamous cell carcinoma

Pol Specenier et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2018)

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Review Otorhinolaryngology

Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma

Karl Payne et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2018)

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Review Biochemistry & Molecular Biology

Current Insights into Oral Cancer Epigenetics

Alexandra Iulia Irimie et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Biochemistry & Molecular Biology

Nerve Growth Factor (NGF)Receptor Survival Axis in Head and Neck Squamous Cell Carcinoma

Jozsef Dudas et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Biochemistry & Molecular Biology

Potential Health Benefits of Olive Oil and Plant Polyphenols

Monika Gorzynik-Debicka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Biochemistry & Molecular Biology

Aldehyde-Induced DNA and Protein Adducts as Biomarker Tools for Alcohol Use Disorder

Helen M. Heymann et al.

TRENDS IN MOLECULAR MEDICINE (2018)

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Review Oncology

Nutrition impact symptoms and associated outcomes in post-chemoradiotherapy head and neck cancer survivors: a systematic review

Sylvia L. Crowder et al.

JOURNAL OF CANCER SURVIVORSHIP (2018)

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Article Microbiology

Oral Microbiota Community Dynamics Associated With Oral Squamous Cell Carcinoma Staging

Chia-Yu Yang et al.

FRONTIERS IN MICROBIOLOGY (2018)

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Article Microbiology

Characterization of oral microbiota and acetaldehyde production

Shigeyuki Yokoyama et al.

JOURNAL OF ORAL MICROBIOLOGY (2018)

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Article Microbiology

Drinking alcohol is associated with variation in the human oral microbiome in a large study of American adults

Xiaozhou Fan et al.

MICROBIOME (2018)

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Review Medicine, Research & Experimental

Preventive measures in oral cancer: An overview

Sharon D'souza et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Pharmacology & Pharmacy

Precision medicine in head and neck cancer

Orit Kaidar-Person et al.

DRUG RESISTANCE UPDATES (2018)

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Article Substance Abuse

How alcohol industry organisations mislead the public about alcohol and cancer

Mark Petticrew et al.

DRUG AND ALCOHOL REVIEW (2018)

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Review Cell Biology

DNMT3B Functions: Novel Insights From Human Disease

Miriam Gagliardi et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)

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Article Medicine, Legal

Ethyl glucuronide in keratinous matrices as biomarker of alcohol use: A correlation study between hair and nails

Delphine Cappelle et al.

FORENSIC SCIENCE INTERNATIONAL (2017)

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Article Biochemistry & Molecular Biology

Coinfection with Epstein-Barr Virus (EBV), Human Papilloma Virus (HPV) and Polyoma BK Virus (BKPyV) in Laryngeal, Oropharyngeal and Oral Cavity Cancer

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Nutrition & Dietetics

Olive polyphenol effects in a mouse model of chronic ethanol addiction

Valentina Carito et al.

NUTRITION (2017)

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Review Oncology

Liquid biopsy: An emerging prognostic and predictive tool in Head and Neck Squamous Cell Carcinoma (HNSCC). Focus on Circulating Tumor Cells (CTCs)

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ORAL ONCOLOGY (2017)

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Article Toxicology

Ethylglucuronide in the urine as a marker of alcohol consumption during pregnancy: Comparison with four alcohol screening questionnaires

Giampiero Ferraguti et al.

TOXICOLOGY LETTERS (2017)

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Article Multidisciplinary Sciences

Variations in oral microbiota associated with oral cancer

Hongsen Zhao et al.

SCIENTIFIC REPORTS (2017)

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Article Oncology

Genome-wide DNA methylation profile identified a unique set of differentially methylated immune genes in oral squamous cell carcinoma patients in India

Baidehi Basu et al.

CLINICAL EPIGENETICS (2017)

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Article Oncology

Heterogeneous impact of alcohol consumption according to treatment method on survival in head and neck cancer: A prospective study

Michi Sawabe et al.

CANCER SCIENCE (2017)

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Review Oncology

Tobacco-related carcinogenesis in head and neck cancer

Ashok R. Jethwa et al.

CANCER AND METASTASIS REVIEWS (2017)

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Article Oncology

Alcohol and cigarette consumption predict mortality in patients with head and neck cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

L. Giraldi et al.

ANNALS OF ONCOLOGY (2017)

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Article Substance Abuse

Ethyl Glucuronide Elimination Kinetics in Fingernails and Comparison to Levels in Hair

Jan Toralf Fosen et al.

ALCOHOL AND ALCOHOLISM (2017)

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Review Oncology

Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis

Alhadi Almangush et al.

BRITISH JOURNAL OF CANCER (2017)

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Review Oncology

Alcohol and head and neck cancer

Daisuke Kawakita et al.

CANCER AND METASTASIS REVIEWS (2017)

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Review Biochemistry & Molecular Biology

The oral cavity microbiota: between health, oral disease, and cancers of the aerodigestive tract

Pierre Le Bars et al.

CANADIAN JOURNAL OF MICROBIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Paternal alcohol exposure in mice alters brain NGF and BDNF and increases ethanol-elicited preference in male offspring

Mauro Ceccanti et al.

ADDICTION BIOLOGY (2016)

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Article Public, Environmental & Occupational Health

Combined effect of tobacco smoking and alcohol drinking in the risk of head and neck cancers: a re-analysis of case-control studies using bi-dimensional spline models

Luigino Dal Maso et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2016)

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Article Oncology

Cancer incidence and mortality attributable to alcohol consumption

Delphine Praud et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

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Review Developmental Biology

Fetal oxidative stress mechanisms of neurodevelopmental deficits and exacerbation by ethanol and methamphetamine

Peter G. Wells et al.

BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS (2016)

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Article Pharmacology & Pharmacy

The effects of motor rehabilitation training on clinical symptoms and serum BDNF levels in Parkinson's disease subjects

Francesco Angelucci et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2016)

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Review Biochemistry & Molecular Biology

Neurotrophins' Modulation by Olive Polyphenols

Valentina Carito et al.

CURRENT MEDICINAL CHEMISTRY (2016)

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Article Public, Environmental & Occupational Health

Prognostic Value of Drinking Status and Aldehyde Dehydrogenase 2 Polymorphism in Patients With Head and Neck Squamous Cell Carcinoma

Daisuke Kawakita et al.

JOURNAL OF EPIDEMIOLOGY (2016)

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Article Dentistry, Oral Surgery & Medicine

HPV prevalence and p16INKa overexpression in non-smoking non-drinking oral cavity cancer patients

E. Dediol et al.

ORAL DISEASES (2016)

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Article Oncology

The development of a liquid biopsy for head and neck cancers

Henri Schmidt et al.

ORAL ONCOLOGY (2016)

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Article Toxicology

Deficient DNA repair exacerbates ethanol-initiated DNA oxidation and embryopathies in ogg1 knockout mice: gender risk and protection by a free radical spin trapping agent

Lutfiya Miller-Pinsler et al.

ARCHIVES OF TOXICOLOGY (2016)

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Article Pharmacology & Pharmacy

Deep TMS on alcoholics: effects on cortisolemia and dopamine pathway modulation. A pilot study

Marco Ceccanti et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2015)

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Article Oncology

New DNA Methylation Markers and Global DNA Hypomethylation Are Associated with Oral Cancer Development

Jean-Philippe Foy et al.

CANCER PREVENTION RESEARCH (2015)

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Review Oncology

Epidemiology of Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma

Maura L. Gillison et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

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Article Multidisciplinary Sciences

Comprehensive genomic characterization of head and neck squamous cell carcinomas

Michael S. Lawrence et al.

NATURE (2015)

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Review Oncology

Update on Head and Neck Cancer: Current Knowledge on Epidemiology, Risk Factors, Molecular Features and Novel Therapies

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ONCOLOGY (2015)

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Article Dentistry, Oral Surgery & Medicine

Acetaldehyde production by major oral microbes

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ORAL DISEASES (2015)

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Article Oncology

Targeting angiogenesis in head and neck cancer

Maria Vassilakopoulou et al.

ORAL ONCOLOGY (2015)

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Article Psychology, Biological

Spatial learning in men undergoing alcohol detoxification

Mauro Ceccanti et al.

PHYSIOLOGY & BEHAVIOR (2015)

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Article Pharmacology & Pharmacy

Embryonic catalase protects against ethanol embryopathies in acatalasemic mice and transgenic human catalase-expressing mice in embryo culture

Lutfiya Miller-Pinsler et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2015)

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Article Substance Abuse

Prevalence of Ethyl Glucuronide and Ethyl Sulphate Among Patients Injured When Driving or at Work

Stig Tore Bogstrand et al.

ALCOHOL AND ALCOHOLISM (2015)

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Article Dentistry, Oral Surgery & Medicine

In vitro expression of Candida albicans alcohol dehydrogenase genes involved in acetaldehyde metabolism

M. M. Bakri et al.

MOLECULAR ORAL MICROBIOLOGY (2015)

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Review Biochemistry & Molecular Biology

Alcohol, Aldehydes, Adducts and Airways

Muna Sapkota et al.

BIOMOLECULES (2015)

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Review Gastroenterology & Hepatology

The Synergistic Effects of Alcohol and Tobacco Consumption on the Risk of Esophageal Squamous Cell Carcinoma: A Meta-Analysis

Anoop Prabhu et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2014)

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Review Environmental Sciences

Acetaldehyde and the Genome: Beyond Nuclear DNA Adducts and Carcinogenesis

Philip J. Brooks et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2014)

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Article Oncology

A comprehensive evaluation of human papillomavirus positive status and p16INK4a overexpression as a prognostic biomarker in head and neck squamous cell carcinoma

Zeyi Deng et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

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Article Dentistry, Oral Surgery & Medicine

Investigation of p16INK4a as a prognostic biomarker in oral epithelial dysplasia

Paul Nankivell et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2014)

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Article Chemistry, Applied

Effects of olive leaf polyphenols on male mouse brain NGF, BDNF and their receptors TrkA, TrkB and p75

Valentina Carito et al.

NATURAL PRODUCT RESEARCH (2014)

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Article Medicine, Research & Experimental

Afatinib versus placebo as adjuvant therapy after chemoradiation in a double-blind, phase III study (LUX-Head & Neck 2) in patients with primary unresected, clinically intermediate-to-high-risk head and neck cancer: study protocol for a randomized controlled trial

Barbara Burtness et al.

TRIALS (2014)

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Article Immunology

Streptococcus mitis Strains Causing Severe Clinical Disease in Cancer Patients

Samuel A. Shelburne et al.

EMERGING INFECTIOUS DISEASES (2014)

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Review Gastroenterology & Hepatology

Systematic review with meta-analysis: race-specific effects of alcohol and tobacco on the risk of oesophageal squamous cell carcinoma

A. Prabhu et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2013)

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Article Oncology

Autophagy Control by the VEGF-C/NRP-2 Axis in Cancer and Its Implication for Treatment Resistance

Marissa J. Stanton et al.

CANCER RESEARCH (2013)

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Article Biochemistry & Molecular Biology

The free radical spin trapping agent phenylbutylnitrone reduces fetal brain DNA oxidation and postnatal cognitive deficits caused by in utero exposure to a non-structurally teratogenic dose of ethanol: A role for oxidative stress

Lutfiya Miller et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

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Review Agriculture, Multidisciplinary

Overview of Metabolism and Bioavailability Enhancement of Polyphenols

Urszula Lewandowska et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2013)

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Article Dentistry, Oral Surgery & Medicine

Production of carcinogenic acetaldehyde by Candida albicans from patients with potentially malignant oral mucosal disorders

M. L. Gainza-Cirauqui et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2013)

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Article Dentistry, Oral Surgery & Medicine

Fermentative 2-carbon metabolism produces carcinogenic levels of acetaldehyde in Candida albicans

E. Marttila et al.

MOLECULAR ORAL MICROBIOLOGY (2013)

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Article Nutrition & Dietetics

Effects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brain

Sara De Nicolo et al.

NUTRITION (2013)

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Article Oncology

Global analysis of DNA methylation changes during progression of oral cancer

Rebecca Towle et al.

ORAL ONCOLOGY (2013)

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Article Multidisciplinary Sciences

Distinct Effects of Alcohol Consumption and Smoking on Genetic Alterations in Head and Neck Carcinoma

Mitsuyoshi Urashima et al.

PLOS ONE (2013)

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Review Oncology

VEGF targets the tumour cell

Hira Lal Goel et al.

NATURE REVIEWS CANCER (2013)

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Article Otorhinolaryngology

Biological and clinical significance of p75NTR expression in laryngeal squamous epithelia and laryngocarcinoma

Xiaoming Li et al.

ACTA OTO-LARYNGOLOGICA (2012)

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Review Dentistry, Oral Surgery & Medicine

Green tea: A promising natural product in oral health

Baruch Narotzki et al.

ARCHIVES OF ORAL BIOLOGY (2012)

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Article Oncology

Kinetics of DNA Adduct Formation in the Oral Cavity after Drinking Alcohol

Silvia Balbo et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2012)

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Review Otorhinolaryngology

Tobacco carcinogen metabolites and DNA adducts as biomarkers in Head and Neck cancer: Potential screening tools and prognostic indicators

Samir S. Khariwala et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2012)

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Article Geriatrics & Gerontology

Early exposure to ethanol or red wine and long-lasting effects in aged mice. A study on nerve growth factor, brain-derived neurotrophic factor, hepatocyte growth factor, and vascular endothelial growth factor

Mauro Ceccanti et al.

NEUROBIOLOGY OF AGING (2012)

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Article Oncology

Do Tobacco and Alcohol Modify Protective Effects of Diet on Oral Carcinogenesis?

Tatiana Natasha Toporcov et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2012)

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Review Nutrition & Dietetics

Wine, Beer, Alcohol and Polyphenols on Cardiovascular Disease and Cancer

Sara Arranz et al.

NUTRIENTS (2012)

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Review Neurosciences

The role of oxidative stress in fetal alcohol spectrum disorders

Patricia S. Brocardo et al.

BRAIN RESEARCH REVIEWS (2011)

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Article Oncology

Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells

Jacqueline A. Gasche et al.

INTERNATIONAL JOURNAL OF CANCER (2011)

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Article Neurosciences

Nerve Growth Factor as a Signaling Molecule for Nerve Cells and also for the Neuroendocrine-Immune Systems

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REVIEWS IN THE NEUROSCIENCES (2011)

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Article Oncology

Endothelial Cell-Initiated Signaling Promotes the Survival and Self-Renewal of Cancer Stem Cells

Sudha Krishnamurthy et al.

CANCER RESEARCH (2010)

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Review Cell Biology

Neuroadipology: a novel component of neuroendocrinology

George N. Chaldakov et al.

CELL BIOLOGY INTERNATIONAL (2010)

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Review Biochemistry & Molecular Biology

Formation of acetaldehyde-derived DNA adducts due to alcohol exposure

Hsu-Sheng Yu et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2010)

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Article Oncology

Epidermal growth factor receptor targeted therapy in stage III and IV head and neck cancer

C. Cripps et al.

Current Oncology (2010)

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Article Oncology

p16INK4A promoter hypermethylation is associated with invasiveness and prognosis of oral squamous cell carcinoma in an age-dependent manner

Pei-Fen Su et al.

ORAL ONCOLOGY (2010)

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Article Multidisciplinary Sciences

Genetic and Epigenetic Somatic Alterations in Head and Neck Squamous Cell Carcinomas Are Globally Coordinated but Not Locally Targeted

Graham M. Poage et al.

PLOS ONE (2010)

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Article Dentistry, Oral Surgery & Medicine

Short-term effect of chewing gums containing probiotic Lactobacillus reuteri on the levels of inflammatory mediators in gingival crevicular fluid

Svante Twetman et al.

ACTA ODONTOLOGICA SCANDINAVICA (2009)

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Article Substance Abuse

Protective Effect of Vitamin E Against Ethanol-Induced Hyperhomocysteinemia, DNA Damage, and Atrophy in the Developing Male Rat Brain

Alireza Shirpoor et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2009)

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Review Pathology

Molecular Pathology of Head and Neck Cancer: Implications for Diagnosis, Prognosis, and Treatment

Sara I. Pai et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2009)

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Article Biochemistry & Molecular Biology

Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer

Yu-Chih Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

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Article Oncology

Impact of Multiple Alcohol Dehydrogenase Gene Polymorphisms on Risk of Upper Aerodigestive Tract Cancers in a Japanese Population

Isao Oze et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2009)

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Article Oncology

Aldehyde Dehydrogenase 2 and Head and Neck Cancer: A Meta-analysis Implementing a Mendelian Randomization Approach

Stefania Boccia et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2009)

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Article Oncology

Interaction between Tobacco and Alcohol Use and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

Mia Hashibe et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2009)

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Article Oncology

Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese

Junya Kanda et al.

CANCER SCIENCE (2009)

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Article Oncology

Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma

Carmen J. Marsit et al.

CARCINOGENESIS (2009)

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Review Food Science & Technology

Fighting Cancer with Red Wine? Molecular Mechanisms of Resveratrol

Thomas E. Kraft et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2009)

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Article Oncology

Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis

Chien-Hung Lee et al.

INTERNATIONAL JOURNAL OF CANCER (2009)

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Article Cell Biology

The Low-Affinity Receptor for Neurotrophins p75NTR Plays a Key Role for Satellite Cell Function in Muscle Repair Acting via RhoA

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MOLECULAR BIOLOGY OF THE CELL (2009)

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Review Oncology

Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer

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LANCET ONCOLOGY (2009)

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Article Psychology, Biological

Changes in cognition induced by social isolation in the mouse are restored by electro-acupuncture

Luigi Manni et al.

PHYSIOLOGY & BEHAVIOR (2009)

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Article Oncology

Acetaldehyde production from ethanol and glucose by non-Candida albicans yeasts in vitro

Mikko T. Nieminen et al.

ORAL ONCOLOGY (2009)

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Article Multidisciplinary Sciences

Genome-Wide Hypomethylation in Head and Neck Cancer Is More Pronounced in HPV-Negative Tumors and Is Associated with Genomic Instability

Kristy L. Richards et al.

PLOS ONE (2009)

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Article Toxicology

Black ginseng inhibits ethanol-induced teratogenesis in cultured mouse embryos through its effects on antioxidant activity

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TOXICOLOGY IN VITRO (2009)

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Article Toxicology

Hepatocyte growth factor, vascular endothelial growth factor, glial cell-derived neurotrophic factor and nerve growth factor are differentially affected by early chronic ethanol or red wine intake

Marco Fiore et al.

TOXICOLOGY LETTERS (2009)

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Article Medicine, General & Internal

The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption

Philip J. Brooks et al.

PLOS MEDICINE (2009)

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Article Gastroenterology & Hepatology

STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells

Jin Si et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

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Article Oncology

Differential roles of p16INK4A and p14ARF genes in prognosis of oral carcinoma

R. Sailasree et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2008)

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Article Oncology

Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck:: A case-control study

Zhensheng Liu et al.

CANCER LETTERS (2008)

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Article Medicine, General & Internal

Platinum-based chemotherapy plus cetuximab in head and neck cancer

Jan B. Vermorken et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Article Medical Laboratory Technology

Determination of fatty acid ethyl esters (FAEE) and ethyl glucuronide (EtG) in hair: A promising way for retrospective detection of alcohol abuse during pregnancy?

Fritz Pragst et al.

THERAPEUTIC DRUG MONITORING (2008)

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Article Clinical Neurology

Lifestyle-related factors in predementia and dementia syndromes

Vincenzo Solfrizzi et al.

Expert Review of Neurotherapeutics (2007)

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Article Oncology

Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer

Katie M. Applebaum et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)

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Article Oncology

Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol

Tomonari Matsuda et al.

CARCINOGENESIS (2007)

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Article Oncology

DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage

Ian M. Smith et al.

INTERNATIONAL JOURNAL OF CANCER (2007)

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Review Biochemistry & Molecular Biology

Lipid peroxidation-induced DNA damage in cancer-prone inflammatory diseases: A review of published adduct types and levels in humans

Urmila Nair et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

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Article Clinical Neurology

Chronic ethanol exposure causes mitochondrial dysfunction and oxidative stress in immature central nervous system neurons

Jennifer Chu et al.

ACTA NEUROPATHOLOGICA (2007)

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Article Oncology

Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer:: Pooled analysis in the international head and neck cancer epidemiology consortium

Mia Hashibe et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)

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Article Oncology

The expression of p53-induced protein with death domain (Pidd) and apoptosis in oral squamous cell carcinoma

G. Bradley et al.

BRITISH JOURNAL OF CANCER (2007)

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Article Public, Environmental & Occupational Health

Contribution of tobacco and alcohol to the high rates of squamous cell carcinoma of the supraglottis and glottis in central europe

Mia Hashibe et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2007)

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Article Oncology

Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma

Sufi Mary Thomas et al.

CANCER RESEARCH (2006)

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Article Oncology

Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa

Keizo Kato et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2006)

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Article Substance Abuse

Antioxidative treatment diminishes ethanol-induced congenital malformations in the rat

Parri Wentzel et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2006)

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Review Gastroenterology & Hepatology

Acute alcoholic hepatitis

Mauro Ceccanti et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2006)

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Review Oncology

Epidermal growth factor receptor biology in head and neck cancer

Shailaja Kalyankrishna et al.

JOURNAL OF CLINICAL ONCOLOGY (2006)

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Article Oncology

Promoter methylation of P16, RARβ, E-cadherin, cyclin A1 and cytoglobin in oral cancer:: quantitative evaluation using pyrosequencing

RJ Shaw et al.

BRITISH JOURNAL OF CANCER (2006)

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Review Oncology

Alcohol and cancer

P Boffetta et al.

LANCET ONCOLOGY (2006)

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Review Oncology

Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma

PK Ha et al.

LANCET ONCOLOGY (2006)

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Article Plant Sciences

Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life

Barry Halliwell

PLANT PHYSIOLOGY (2006)

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Article Substance Abuse

Hypertension in early alcohol withdrawal in chronic alcoholics

M Ceccanti et al.

ALCOHOL AND ALCOHOLISM (2006)

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Review Oncology

Role of cytokines in head and neck squamous cell carcinoma

Ralph Pries et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2006)

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Article Dentistry, Oral Surgery & Medicine

Oral lactobacilli in chronic periodontitis and periodontal health:: species composition and antimicrobial activity

P Koll-Klais et al.

ORAL MICROBIOLOGY AND IMMUNOLOGY (2005)

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Article Substance Abuse

DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis

PJ Brooks et al.

ALCOHOL (2005)

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Article Neurosciences

Ascorbic acid inhibits ROS production, NF-κB activation and prevents ethanol-induced growth retardation and microencephaly

Y Peng et al.

NEUROPHARMACOLOGY (2005)

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Review Genetics & Heredity

Endogenous DNA damage in humans: a review of quantitative data

R De Bont et al.

MUTAGENESIS (2004)

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Article Public, Environmental & Occupational Health

A meta-analysis of alcohol consumption and the risk of 15 diseases

G Corrao et al.

PREVENTIVE MEDICINE (2004)

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Article Oncology

Hypermethylation of the retinoic acid receptor-β2 gene in head and neck carcinogenesis

EM Youssef et al.

CLINICAL CANCER RESEARCH (2004)

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Review Oncology

Pathogenetic mechanisms of upper aerodigestive tract cancer in alcoholics

HK Seitz et al.

INTERNATIONAL JOURNAL OF CANCER (2004)

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Article Oncology

Src family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells

Q Zhang et al.

CANCER RESEARCH (2004)

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Article Substance Abuse

Ethyl glucuronide: A biomarker to identify alcohol use by health professionals recovering from substance use disorders

GE Skipper et al.

ALCOHOL AND ALCOHOLISM (2004)

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Article Developmental Biology

Vitamin E protects against alcohol-induced cell loss and oxidative stress in the neonatal rat hippocampus

MD Marino et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2004)

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Article Developmental Biology

Vitamin E amelioration of ethanol neurotoxicity involves modulation of apoptotis-related protein levels in neonatal rat cerebellar granule cells

MB Heaton et al.

DEVELOPMENTAL BRAIN RESEARCH (2004)

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Article Neurosciences

Pycnogenol® and vitamin E inhibit ethanol-induced apoptosis in rat cerebellar granule cells

KI Siler-Marsiglio et al.

JOURNAL OF NEUROBIOLOGY (2004)

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Article Medicine, Legal

Comparison of ethyl glucuronide and fatty acid ethyl ester concentrations in hair of alcoholics, social drinkers and teetotallers

M Yegles et al.

FORENSIC SCIENCE INTERNATIONAL (2004)

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Article Biochemistry & Molecular Biology

Protection from ethanol-induced limb malformations by the superoxide dismutase/catalase mimetic EUK-134

SY Chen et al.

FASEB JOURNAL (2004)

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Article Substance Abuse

Concentration of fatty acid ethyl esters in hair of alcoholics: Comparison to other biological state markers and self reported-ethanol intake

FM Wurst et al.

ALCOHOL AND ALCOHOLISM (2004)

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Article Toxicology

Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties

S Azam et al.

TOXICOLOGY IN VITRO (2004)

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Review Nutrition & Dietetics

Polyphenols:: food sources and bioavailability

C Manach et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2004)

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Article Oncology

A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8

HC Hafkamp et al.

INTERNATIONAL JOURNAL OF CANCER (2003)

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Review Oncology

Wine and resveratrol: mechanisms of cancer prevention?

F Bianchini et al.

EUROPEAN JOURNAL OF CANCER PREVENTION (2003)

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Article Biochemistry & Molecular Biology

Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor

VWY Lui et al.

ONCOGENE (2003)

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Article Oncology

Promoter hypermethylation profile of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma

M Viswanathan et al.

INTERNATIONAL JOURNAL OF CANCER (2003)

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Review Biochemical Research Methods

Chromatographic methods for the determination of markers of chronic and acute alcohol consumption

F Musshoff

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2002)

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Review Biochemistry & Molecular Biology

DNA adduct burden and tobacco carcinogenesis

JK Wiencke

ONCOGENE (2002)

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Article Otorhinolaryngology

Human papillomavirus and p53 mutational status as prognostic factors in head and neck carcinoma

EA Sisk et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2002)

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Article Allergy

Nerve growth factor and asthma

S Bonini et al.

ALLERGY (2002)

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Article Neurosciences

Long-lasting effects of prenatal MAM treatment on water maze performance in rats: Associations with altered brain development and neurotrophin levels

M Fiore et al.

NEUROTOXICOLOGY AND TERATOLOGY (2002)

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Article Oncology

A meta-analysis of alcohol drinking and cancer risk

V Bagnardi et al.

BRITISH JOURNAL OF CANCER (2001)

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Article Cardiac & Cardiovascular Systems

Nerve growth factor levels and mast cell distribution in human coronary atherosclerosis

GN Chaldakov et al.

ATHEROSCLEROSIS (2001)

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Review Medical Laboratory Technology

Biochemical detection and monitoring of alcohol abuse and abstinence

PC Sharpe

ANNALS OF CLINICAL BIOCHEMISTRY (2001)

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Article Biochemistry & Molecular Biology

Protective effect of folic acid against oxidative stress produced in 21-day postpartum rats by maternal-ethanol chronic consumption during pregnancy and lactation period

MJ Cano et al.

FREE RADICAL RESEARCH (2001)

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Review Dentistry, Oral Surgery & Medicine

The p53 molecule and its prognostic role in squamous cell carcinomas of the head and neck

K Nylander et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2000)

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Review Medicine, Research & Experimental

Data and hypotheses on the role of nerve growth factor and other neurotrophins in psychiatric disorders

G Bersani et al.

MEDICAL HYPOTHESES (2000)

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Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents

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