The Combination of Solid-State Chemistry and Medicinal Chemistry as the Basis for the Synthesis of Theranostics Platforms

Review Chemistry, Applied

Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

Milad Ashrafizadeh et al.

Summary: Hyaluronic acid-modified nanostructures can enhance the delivery of doxorubicin to cancer cells, overcoming chemoresistance and providing a platform for the co-delivery of genes and drugs.

CARBOHYDRATE POLYMERS (2021)

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Review Chemistry, Multidisciplinary

Cyclodextrins-modified metallic nanoparticles for effective cancer therapy

Sahil Gandhi et al.

Summary: The use of cyclodextrin-complexed metallic nanoparticles as a novel platform for cancer therapy can effectively overcome limitations of conventional chemotherapy. This approach improves the delivery efficiency of anticancer drugs, reduces toxic side effects, and holds great potential for clinical application.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Oncology

Dendrimer-modified gold nanorods as a platform for combinational gene therapy and photothermal therapy of tumors

Lili Ye et al.

Summary: The study synthesized a novel nanomaterial combining gene therapy and photothermal therapy for the treatment of colon cancer. The nanomaterial showed effective delivery of genes to cancer cells and achieved combined photothermal therapy and gene therapy, with significantly better treatment outcomes for colon cancer cells compared to single-mode treatments. Animal experiments confirmed the nanomaterial's ability to achieve tumor thermal imaging, targeted CT imaging, photothermal therapy, and gene therapy in vivo.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Biotechnology & Applied Microbiology

Porphyrin-lipid stabilized paclitaxel nanoemulsion for combined photodynamic therapy and chemotherapy

Enling Chang et al.

Summary: The PLNE-PTX nanoemulsion, utilizing porphyrin-lipids, effectively combines PDT and chemotherapy, demonstrating superior anti-tumor effects and potential to reduce side effects associated with monotherapy chemotherapy. Its inherent imaging modality enables real-time tracking and spatial and temporal regulation to improve cancer treatment.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Two-dimensional intermetallic PtBi/Pt core/shell nanoplates overcome tumor hypoxia for enhanced cancer therapy

Yongchun Liu et al.

Summary: The study created PtBi/Pt nanoplates to address tumor hypoxia and demonstrated significant enhancement in photothermal/radiotherapy effects. The PEGylated PtBi NPs showed excellent biocompatibility and multimodal contrast enhancement, indicating potential as a novel nanoplatform for future multimodal imaging-guided synergistic cancer therapy.

NANOSCALE (2021)

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Article Materials Science, Biomaterials

MnO2 nanoflowers as a multifunctional nano-platform for enhanced photothermal/photodynamic therapy and MR imaging

Wanru Sun et al.

Summary: A multifunctional theranostic platform (MnO2-SiO2-APTES&Ce6 (MSA&C)) incorporating PDT and NIR-II photothermal therapy was developed based on MnO2 nanoflowers. The platform effectively loaded photosensitizer, relieved tumor hypoxia, and provided tumor-specific imaging. The combination of PDT and NIR-II PTT showed improved therapeutic efficacy by enhancing ROS generation and down-regulating HSP 70 expression.

BIOMATERIALS SCIENCE (2021)

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Article Nanoscience & Nanotechnology

Multifunctional Theranostic Graphene Oxide Nanoflakes as MR Imaging Agents with Enhanced Photothermal and Radiosensitizing Properties

Jaber Beik et al.

Summary: The multifunctional theranostic nanostructures GO-SPIO-Au NFs showed great potential for dual photo/radiotherapy in cancer treatment, with enhanced therapeutic efficacy in mouse carcinoma model. This nanoplatform also has the ability to be detected by magnetic resonance imaging, making it a promising nanomaterial for cancer imaging and therapy.

ACS APPLIED BIO MATERIALS (2021)

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Article Engineering, Biomedical

Janus metallic mesoporous silica nanoparticles: Unique structures for cancer theranostics

Dan Shao et al.

Summary: JMMSNs, with unique structures and properties, are utilized for cancer treatment and diagnostics. Magnetic JMMSNs are used for tumor cell isolation and MRI, plasmonic JMMSNs for Raman scattering detection and photoacoustic imaging, and upconversion JMMSNs for photoactivation-based drug release and therapy.

CURRENT OPINION IN BIOMEDICAL ENGINEERING (2021)

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Review Chemistry, Multidisciplinary

Gadolinium theranostics for the diagnosis and treatment of cancer

Amy G. Robertson et al.

Summary: According to the World Health Organization, the number of new cancer cases and deaths is expected to rise in the next decade, calling for the development of new and effective cancer treatments and diagnostic tools. Theranostics, particularly those utilizing materials like gadolinium, are showing promise in personalized management of oncology patients, representing a new direction in cancer research.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Nanoscience & Nanotechnology

Chitosan Nanococktails Containing Both Ceria and Superparamagnetic Iron Oxide Nanoparticles for Reactive Oxygen Species-Related Theranostics

Yuao Wu et al.

Summary: The study investigated the feasibility of using chitosan nanococktails for the treatment and diagnosis of ROS-related diseases, demonstrating their effectiveness in ROS scavenging and MRI contrast through experiments, suggesting their potential as a platform for treating and diagnosing ROS-related diseases. Chit-IOCO was found to be less toxic to cells and exhibited higher MRI relaxivity compared to Chit-TPP-IOCO, indicating its greater effectiveness.

ACS APPLIED NANO MATERIALS (2021)

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Article Materials Science, Biomaterials

Multicomponent-assembled nanodiamond hybrids for targeted and imaging guided triple-negative breast cancer therapy via a ternary collaborative strategy

Xinyue Cui et al.

Summary: The study assembled a NDs-based multicomponent theranostic platform for dual-modal fluorescence/photoacoustic imaging guided triple-collaborative Cur/photothermal/photodynamic therapy against TNBC. The platform possessed uniform size, high drug-loading ability, and excellent colloidal stability.

BIOMATERIALS SCIENCE (2021)

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Review Nanoscience & Nanotechnology

Dendrimer Architectonics to Treat Cancer and Neurodegenerative Diseases with Implications in Theranostics and Personalized Medicine

Hariharan Moorthy et al.

Summary: Theranostics, integrating diagnostic and therapeutic functions in a single platform, allows for noninvasive detection and treatment while monitoring disease progression and therapeutic efficacy in conditions like cancer and Alzheimer's disease. Theranostic tools can function independently or with the assistance of carriers like liposomes, micelles, polymers, or dendrimers, offering multifunctional properties for simultaneous imaging and drug delivery.

ACS APPLIED BIO MATERIALS (2021)

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Review Biochemistry & Molecular Biology

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Jingou Liang et al.

MOLECULES (2020)

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Article Dentistry, Oral Surgery & Medicine

Biogenic synthesis and antimicrobial activity of silica-coated silver nanoparticles for esthetic dental applications

Marcela Charantola Rodrigues et al.

JOURNAL OF DENTISTRY (2020)

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Article Chemistry, Multidisciplinary

Chemisorption of Glycidyl Spacer on Magnetic Nanoparticles and Immobilization of Albumin and Quinacrine

D. V. Korolev et al.

RUSSIAN JOURNAL OF GENERAL CHEMISTRY (2020)

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Article Materials Science, Biomaterials

Red fluorescent ZnO nanoparticle grafted with polyglycerol and conjugated RGD peptide as drug delivery vehicles for efficient target cancer therapy

Xiaoxin Yang et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Multidisciplinary Sciences

Investigation of the adsorption capacity of the enterosorbent Enterosgel for a range of bacterial toxins, bile acids and pharmaceutical drugs

Carol A. Howell et al.

SCIENTIFIC REPORTS (2019)

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Article Engineering, Biomedical

Merging metal organic framework with hollow organosilica nanoparticles as a versatile nanoplatform for cancer theranostics

Liang Chen et al.

ACTA BIOMATERIALIA (2019)

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Review Pharmacology & Pharmacy

Recent Trends of the Bio-Inspired Nanoparticles in Cancer Theranostics

Vijay Sagar Madamsetty et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Nanoscience & Nanotechnology

Doxorubicin and indocyanine green loaded superparamagnetic iron oxide nanoparticles with PEGylated phospholipid coating for magnetic resonance with fluorescence imaging and chemotherapy of glioma

Chen Shen et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Nanoscience & Nanotechnology

Engineered Relaxin as theranostic nanomedicine to diagnose and ameliorate liver cirrhosis

Beata Nagorniewicz et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Article Nanoscience & Nanotechnology

Design of hybrid protein-coated magnetic core-mesoporous silica shell nanocomposites for MRI and drug release assessed in a 3D tumor cell model

Mathilde Menard et al.

NANOTECHNOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Combining hydrophilic chemotherapy and hydrophobic phytotherapy via tumor-targeted albumin-QDs nano-hybrids: covalent coupling and phospholipid complexation approaches

Dina G. Zayed et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Article Ethics

Theranostics: is it really a revolution? Evaluating a new term in medicine

Urban Wiesing

MEDICINE HEALTH CARE AND PHILOSOPHY (2019)

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Article Medicine, Research & Experimental

Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles

Guorui Jin et al.

THERANOSTICS (2019)

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Article Medicine, Research & Experimental

Redox Dual-Responsive and O2-Evolving Theranostic Nanosystem for Highly Selective Chemotherapy against Hypoxic Tumors

Huachao Chen et al.

THERANOSTICS (2019)

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Article Engineering, Biomedical

Responsive antimicrobial dental adhesive based on drug-silica co-assembled particles

Cameron A. Stewart et al.

ACTA BIOMATERIALIA (2018)

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Article Chemistry, Multidisciplinary

Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging-Guided Combination Therapy of Tumors

Shiyi Lu et al.

ADVANCED SCIENCE (2018)

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Article Medicine, Research & Experimental

Therapeutic Fluorescent Hybrid Nanoparticles for Traceable Delivery of Glucocorticoids to Inflammatory Sites

Joanna Napp et al.

THERANOSTICS (2018)

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Article Medicine, Research & Experimental

Nanosonosensitizers for Highly Efficient Sonodynamic Cancer Theranostics

Ju Huang et al.

THERANOSTICS (2018)

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Article Medicine, Research & Experimental

Self-assembly of porphyrin-grafted lipid into nanoparticles encapsulating doxorubicin for synergistic chemo-photodynamic therapy and fluorescence imaging

Sadaf Hameed et al.

THERANOSTICS (2018)

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Proceedings Paper Engineering, Electrical & Electronic

Fluorescence imaging of the nanoparticles modified with indocyanine green

K. G. Gareev et al.

4TH INTERNATIONAL SCHOOL AND CONFERENCE ON OPTOELECTRONICS, PHOTONICS, ENGINEERING AND NANOSTRUCTURES (SAINT PETERSBURG OPEN 2017) (2017)

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Article Pharmacology & Pharmacy

Silicon-containing nanocarriers for targeted drug delivery: synthesis, physicochemical properties and acute toxicity

Dmitry L. Sonin et al.

DRUG DELIVERY (2016)

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Review Medicine, Research & Experimental

Nanotheranostics - Application and Further Development of Nanomedicine Strategies for Advanced Theranostics

Madaswamy S. Muthu et al.

THERANOSTICS (2014)

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Review Pathology

Nanotheranostics for personalized medicine

Tae Hyung Kim et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2013)

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Article Nanoscience & Nanotechnology

Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles

Michael Galagudza et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2012)

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Article Chemistry, Physical

In Vivo Toxicity of Intravenously Administered Silica and Silicon Nanoparticles

Sergey Ivanov et al.

MATERIALS (2012)

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Article Medicine, Research & Experimental

Passive and Active Target Delivery of Drugs to Ischemic Myocardium

M. M. Galagudza et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2011)

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Article Pharmacology & Pharmacy

Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization, natural biodistribution, and acute toxicity

Galagudza

International Journal of Nanomedicine (2010)

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Article Engineering, Industrial

Targeted drug delivery to ischemic heart with use of nanoparticulate carriers Concepts, pitfalls and perspectives

Michael Galagudza et al.

JOURNAL OF MANUFACTURING TECHNOLOGY MANAGEMENT (2010)

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Article Nanoscience & Nanotechnology

Passive Targeting of Ischemic Myocardium with the Use of Silica Nanoparticles

M. M. Galagudza et al.

NANOTECHNOLOGIES IN RUSSIA (2010)

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Article Cell Biology

Overexpression of TRPC3 increases apoptosis but not necrosis in response to ischemia-reperfusion in adult mouse cardiomyocytes

Dan Shan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)

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Article Medicine, Research & Experimental

Charcoal tablets in the treatment of patients with irritable bowel syndrome

WD Hübner et al.

ADVANCES IN THERAPY (2002)

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The Combination of Solid-State Chemistry and Medicinal Chemistry as the Basis for the Synthesis of Theranostics Platforms

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