4.7 Article

Liver Progenitor Cells in Massive Hepatic Necrosis-How Can a Patient Survive Acute Liver Failure?

期刊

BIOMOLECULES
卷 12, 期 1, 页码 -

出版社

MDPI
DOI: 10.3390/biom12010066

关键词

acute liver failure; acute-on-chronic liver failure; activin; coagulation factor; HNF4 alpha; liver progenitor cell; massive hepatic necrosis; sepsis; systemic inflammatory response syndrome

资金

  1. Deutsche Forschungsgemeinschaft [WE 5009/9-1]
  2. Chinese-German Cooperation Group [GZ 1517]
  3. BMBF [HiChol 01GM1904A]
  4. Chinese Scholarship Council [201708080020, 201706230256]

向作者/读者索取更多资源

Liver progenitor cells play a key role in acute liver failure by rapidly proliferating and taking over crucial hepatocyte functions. These findings not only enhance our understanding of liver regenerative capability, but also provide potential new targets for pharmacological management of acute liver failure.
Massive hepatic necrosis is the most severe lesion in acute liver failure, yet a portion of patients manage to survive and recover from this high-risk and harsh disease syndrome. The mechanisms underlying recovery remain largely unknown to date. Recent research progress highlights a key role of liver progenitor cells, the smallest biliary cells, in the maintenance of liver homeostasis and thus survival. These stem-like cells rapidly proliferate and take over crucial hepatocyte functions in a severely damaged liver. Hence, the new findings not only add to our understanding of the huge regenerative capability of the liver, but also provide potential new targets for the pharmacological management of acute liver failure in clinical practice.

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