期刊
BIOMOLECULES
卷 12, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/biom12010004
关键词
IL-10; natural killer cells; inflammation; systemic infections
资金
- Consejo Nacional de Ciencia y Tecnologia (CONACYT), Investigacion en Ciencia Basica, Mexico [223414]
NK cells have the ability to produce both pro-inflammatory and anti-inflammatory cytokines, playing a crucial role in regulating inflammation during systemic infection. Understanding the factors driving the production of IL-10 by NK cells and its impact is important for therapeutic advancements in diseases like sepsis.
Natural killer (NK) cells have the dual ability to produce pro-inflammatory (IFN gamma) and anti-inflammatory (IL-10) cytokines during systemic infection, which points to their crucial role both as inflammatory effectors for infection clearance and as regulators to counterbalance inflammation to limit immune-mediated damage to the host. In particular, immunosuppressive IL-10 secretion by NK cells has been described to occur in systemic, but not local, infections as a recent immunoregulatory mechanism of inflammation that may be detrimental or beneficial, depending on the timing of release, type of disease, or the infection model. Understanding the factors that drive the production of IL-10 by NK cells and their impact during dualistic inflammatory states, such as sepsis and other non-controlled inflammatory diseases, is relevant for achieving effective therapeutic advancements. In this review, the evidence regarding the immunoregulatory role of IL-10-producing NK cells in systemic infection is summarized and discussed in detail, and the potential molecular mechanisms that drive IL-10 production by NK cells are considered.
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