期刊
BIOMOLECULES
卷 11, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/biom11101426
关键词
obesity; diabetes mellitus; anti-obesity drugs; obesity metabolism; energy balance
资金
- German Research Foundation [SFB 1052, B10, B1, C6]
- Clinician Scientist Programm, Medizinische Fakultaet der Universitaet Leipzig
- Project DEAL
Obesity is a major public health problem worldwide, with its prevalence increasing at an alarming rate. Intensive efforts to understand the pathophysiology and pharmacotherapy of obesity have led to a better understanding of biomolecules and new intersections with the next generation of antidiabetic drugs. This article reviews the effectiveness of approved anti-obesity drugs and other potential therapeutic avenues.
Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat absorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored.
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