期刊
BIOMOLECULES
卷 12, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/biom12010067
关键词
diabetes; pancreatic islet; protease; serpin
资金
- Juvenile Diabetes Research Foundation [17-2013-428]
- American Diabetes Association [1-17-ICTS-083]
- National Institutes of Health [DK108739-01A1]
The regulation of protease and inhibitor balance is crucial for maintaining health. Serine protease inhibitors, known as serpins, have been studied as potential therapeutic targets. Different proteases and serpins play distinct roles in health and disease development.
Regulation of the equilibrium between proteases and their inhibitors is fundamental to health maintenance. Consequently, developing a means of targeting protease activity to promote tissue regeneration and inhibit inflammation may offer a new strategy in therapy development for diabetes and other diseases. Specifically, recent efforts have focused on serine protease inhibitors, known as serpins, as potential therapeutic targets. The serpin protein family comprises a broad range of protease inhibitors, which are categorized into 16 clades that are all extracellular, with the exception of Clade B, which controls mostly intracellular proteases, including both serine- and papain-like cysteine proteases. This review discusses the most salient, and sometimes opposing, views that either inhibition or augmentation of protease activity can bring about positive outcomes in pancreatic islet biology and inflammation. These potential discrepancies can be reconciled at the molecular level as specific proteases and serpins regulate distinct signaling pathways, thereby playing equally distinct roles in health and disease development.
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