4.7 Review

Effect of Bariatric Surgery on Metabolic Diseases and Underlying Mechanisms

期刊

BIOMOLECULES
卷 11, 期 11, 页码 -

出版社

MDPI
DOI: 10.3390/biom11111582

关键词

obesity; metabolic disorders; complications; mechanisms; cardiovascular diseases

资金

  1. Science and Technology Plan of Beijing Tongzhou District [KJ2019CX012-38, KJ2020CX006-11]
  2. Youth Research and Development Fund of Beijing Luhe Hospital, Capital Medical University [LHYY2020-JC10]

向作者/读者索取更多资源

Obesity is a widespread public health issue with various comorbidities, and bariatric surgery is considered an effective treatment method. Different types of bariatric surgery alter food metabolism pathways and reduce stomach capacity to lower food tolerance, leading to a significant decrease in body mass index.
Obesity is a highly prevalent public health concern, attributed to multifactorial causes and limited in treatment options. Several comorbidities are closely associated with obesity such as the development of type 2 diabetes mellitus (T2DM), cardiovascular and cerebrovascular diseases, and nonalcoholic fatty liver disease (NAFLD). Bariatric surgery, which can be delivered in multiple forms, has been remarked as an effective treatment to decrease the prevalence of obesity and its associated comorbidities. The different types of bariatric surgery create a variety of new pathways for food to metabolize in the body and truncate the stomach's caliber. As a result, only a small quantity of food is tolerated, and the body mass index noticeably decreases. This review describes the improvements of obesity and its comorbidities following bariatric surgery and their mechanism of improvement. Additionally, endocrine function improvements after bariatric surgery, which contributes to the patients' health improvement, are described, including the role of glucagon-like peptide-1 (GLP-1), fibroblast growth factors 19 and 21 (FGF-19, FGF-21), and pancreatic peptide YY (PYY). Lastly, some of the complications of bariatric surgery, including osteoporosis, iron deficiency/anemia, and diarrhea, as well as their potential mechanisms, are described.

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