期刊
BIOMOLECULES
卷 11, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/biom11101475
关键词
signal transduction; alternative splicing; alternative polyadenylation; stress response
资金
- Associazione Italiana Ricerca sul Cancro [ID25408, IG23416, MFAG ID24767]
- Breast Cancer Now [2018NovPCC1283]
- Ministry of University (PRIN 2017)
- Italian Ministry of Health [RF2016-02363460, GR-2018-12365706]
- Universita Cattolica del Sacro Cuore
This review explores how signal transduction pathways regulate factors involved in RNA processing events and highlights the impact of various post-translational modifications on RNA-binding proteins. It also illustrates examples of how common signal transduction pathways can modulate biological processes through changes in RNA processing regulation.
Signal transduction pathways transmit the information received from external and internal cues and generate a response that allows the cell to adapt to changes in the surrounding environment. Signaling pathways trigger rapid responses by changing the activity or localization of existing molecules, as well as long-term responses that require the activation of gene expression programs. All steps involved in the regulation of gene expression, from transcription to processing and utilization of new transcripts, are modulated by multiple signal transduction pathways. This review provides a broad overview of the post-translational regulation of factors involved in RNA processing events by signal transduction pathways, with particular focus on the regulation of pre-mRNA splicing, cleavage and polyadenylation. The effects of several post-translational modifications (i.e., sumoylation, ubiquitination, methylation, acetylation and phosphorylation) on the expression, subcellular localization, stability and affinity for RNA and protein partners of many RNA-binding proteins are highlighted. Moreover, examples of how some of the most common signal transduction pathways can modulate biological processes through changes in RNA processing regulation are illustrated. Lastly, we discuss challenges and opportunities of therapeutic approaches that correct RNA processing defects and target signaling molecules.
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